journal article·2017-04

Synthesis and bio-applications of targeted magnetic-fluorescent composite nanoparticles

Hui Xia, Ruijie Tong, Yanling Song, Fang Xiong, Jiman Li, Shichao Wang, Huihui Fu, Jirui Wen, Dongze Li, Ye Zeng, Zhiwei Zhao, Jiang Wu

Journal of Nanoparticle Research· Volume 19· Issue 4
Publisher page

Abstract

Magnetic-fluorescent nanoparticles have a tremendous potential in biology. As the benefits of these materials gained recognition, increasing attention has been given to the conjugation of magnetic-fluorescent nanoparticles with targeting ligands. The magnetic and fluorescent properties of nanoparticles offer several functionalities, including imaging, separation, and visualization, while the presence of a targeting ligand allows for selective cell and tissue targeting. In this review, methods for the synthesis of targeted magnetic-fluorescent nanoparticles are explored, and recent applications of these nanocomposites to the detection and separation of biomolecules, fluorescent and magnetic resonance imaging, and cancer diagnosis and treatment will be summarized. As these materials are further optimized, targeted magnetic-fluorescent nanoparticles hold great promise for the diagnosis and treatment of some diseases.
Source: openaire · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (62)

Show source-provided references
1. Abdel-Mottaleb MM, Beduneau A, Pellequer Y et al (2015) Stability of fluorescent labels in PLGA polymeric nanoparticles: quantum dots versus organic dyes. Int J Pharm 494(1):471–47810.1016/j.ijpharm.2015.08.050 ↗
2. Acharya A, Rawat K, Bhat KA et al (2015) A multifunctional magneto-fluorescent nanocomposite for visual recognition of targeted cancer cells. Materials Research Express 2(11):11540110.1088/2053-1591/2/11/115401 ↗
3. Ahmed S, Dong J, Yui M et al (2013) Quantum dots incorporated magnetic nanoparticles for imaging colon carcinoma cells. Journal of Nanobiotechnology 11:2810.1186/1477-3155-11-28 ↗
4. Assa F, Jafarizadeh-Malmiri H, Ajamein H et al (2016) Chitosan magnetic nanoparticles for drug delivery systems. Crit Rev Biotechnol:1–18
5. Badruddoza AZ, Rahman MT, Ghosh S et al (2013) Beta-cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydr Polym 95(1):449–45710.1016/j.carbpol.2013.02.046 ↗
6. Bao J, Chen W, Liu T et al (2007) Bifunctional Au-Fe3O4 nanoparticles for protein separation. ACS Nano 1(4):293–29810.1021/nn700189h ↗
7. Bhandari S, Khandelia R, Pan UN et al (2015) Surface complexation-based biocompatible magnetofluorescent nanoprobe for targeted cellular imaging. ACS Appl Mater Interfaces 7(32):17552–1755710.1021/acsami.5b04022 ↗
8. Chen YC, Chang WH, Wang SJ et al (2012) Fluorescent magnetic nanoparticles with specific targeting functions for combinded targeting, optical imaging and magnetic resonance imaging. J Biomater Sci Polym Ed 23(15):1903–192210.1163/092050611X598329 ↗
9. Daglioglu C, Okutucu B (2016) Synthesis and characterization of AICAR and DOX conjugated multifunctional nanoparticles as a platform for synergistic inhibition of cancer cell growth. Bioconjug Chem 27(4):1098–111110.1021/acs.bioconjchem.6b00080 ↗
10. Dang SC, Zeng YH, Wang PJ et al (2014) Clodronate-superparamagnetic iron oxide-containing liposomes attenuate renal injury in rats with severe acute pancreatitis. Journal of Zhejiang University Science B 15(6):556–56510.1631/jzus.B1300244 ↗
11. Fahmi MZ, Chen J-K, Huang C-C et al (2015) Phenylboronic acid-modified magnetic nanoparticles as a platform for carbon dot conjugation and doxorubicin delivery. J Mater Chem B 3(27):5532–554310.1039/C5TB00289C ↗
12. Glasgow MDK, Chougule MB (2015) Recent developments in active tumor targeted multifunctional nanoparticles for combination chemotherapy in cancer treatment and imaging. J Biomed Nanotechnol 11(11):1859–189810.1166/jbn.2015.2145 ↗
13. Guo W, Sun X, Jacobson O et al (2015) Intrinsically radioactive [64Cu]CuInS/ZnS quantum dots for PET and optical imaging: improved radiochemical stability and controllable Cerenkov luminescence. ACS Nano 9(1):488–49510.1021/nn505660r ↗
14. Hathaway HJ, Butler KS, Adolphi NL et al (2011) Detection of breast cancer cells using targeted magnetic nanoparticles and ultra-sensitive magnetic field sensors. Breast Cancer Res 13(5):R10810.1186/bcr3050 ↗
15. Heidari Majd M, Barar J, Asgari D et al (2013) Targeted fluoromagnetic nanoparticles for imaging of breast cancer mcf-7 cells. Advanced Pharmaceutical Bulletin 3(1):189–195
16. Hu J, Wen CY, Zhang ZL et al (2013) Optically encoded multifunctional nanospheres for one-pot separation and detection of multiplex DNA sequences. Anal Chem 85(24):11929–1193510.1021/ac4027753 ↗
17. Jang M, Yoon YI, Kwon YS et al (2014) Trastuzumab-conjugated liposome-coated fluorescent magnetic nanoparticles to target breast cancer. Korean J Radiol 15(4):411–42210.3348/kjr.2014.15.4.411 ↗
18. Jang H, Lee C, Nam G-E et al (2016) In vivo magnetic resonance and fluorescence dual imaging of tumor sites by using dye-doped silica-coated iron oxide nanoparticles. J Nanopart Res 18(2)10.1007/s11051-016-3353-x ↗
19. Jayapaul J, Arns S, Bunker M et al (2016) In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts. Nano Res 9(5):1319–133310.1007/s12274-016-1028-7 ↗
20. Jiang D, Ni D, Liu F et al (2016) A fluorescent imaging assay of cast in renal disease based on graphene quantum dots and Fe3O4 nanoparticles. Clinica Chimica Acta; International Journal of Clinical Chemistry 454:94–10110.1016/j.cca.2016.01.001 ↗
21. Jing L, Ding K, Kershaw SV et al (2014) Magnetically engineered semiconductor quantum dots as multimodal imaging probes. Adv Mater 26(37):6367–638610.1002/adma.201402296 ↗
22. Ju E, Chen Z, Li W et al (2016) Embedding magnetic nanoparticles into coordination polymers to mimic zinc ion transporters for targeted tumor therapy. Chem Commun 52(85):12598–1260110.1039/C6CC06467A ↗
23. Kiasat AR, Davarpanah J (2013) Fe3O4@silica sulfuric acid core–shell composite as a novel nanomagnetic solid acid: synthesis, characterization and application as an efficient and reusable catalyst for one-pot synthesis of 3,4-dihydropyrimidinones/thiones under solvent-free conditions. Res Chem Intermed 41(5):2991–300110.1007/s11164-013-1407-6 ↗
24. Kwon D, Lee S, Ahn MM et al (2015) Colorimetric detection of pathogenic bacteria using platinum-coated magnetic nanoparticle clusters and magnetophoretic chromatography. Anal Chim Acta 883:61–6610.1016/j.aca.2015.04.044 ↗
25. Lambregts DM, Maas M, Stokkel MP et al (2016) Magnetic resonance imaging and other imaging modalities in diagnostic and tumor response evaluation. Semin Radiat Oncol 26(3):193–19810.1016/j.semradonc.2016.02.001 ↗
26. Li J, An Y-L, Zang F-C et al (2013) A dual mode targeting probe for distinguishing HER2-positive breast cancer cells using silica-coated fluorescent magnetic nanoparticles. J Nanopart Res 15(10)10.1007/s11051-013-1980-z ↗
27. Li C, Chen T, Ocsoy I et al (2014a) Gold-coated Fe3O4 nanoroses with five unique functions for cancer cell targeting, imaging and therapy. Adv Funct Mater 24(12):1772–178010.1002/adfm.201301659 ↗
28. Li Z, Dong K, Huang S et al (2014b) A smart nanoassembly for multistage targeted drug delivery and magnetic resonance imaging. Adv Funct Mater 24(23):3612–362010.1002/adfm.201303662 ↗
29. Lin J, Li Y, Li Y et al (2015) Drug/dye-loaded, multifunctional PEG-chitosan-iron oxide nanocomposites for methotraxate synergistically self-targeted cancer therapy and dual model imaging. ACS Appl Mater Interfaces 7(22):11908–1192010.1021/acsami.5b01685 ↗
30. Liu Y, Yan T, Li Y et al (2015) A simple label-free photoelectrochemical immunosensor for highly sensitive detection of aflatoxin B1 based on CdS–Fe3O4 magnetic nanocomposites. RSC Adv 5(25):19581–1958610.1039/C4RA15918G ↗
31. Liu Y, Zhang X, Yifeng E et al (2016) Sandwich immunoassays of multicomponent subtrace pathogenic DNA based on magnetic fluorescent encoded nanoparticles. Biomed Res Int 2016:7324384
32. Ma ZY, Liu YP, Bai LY et al (2015) Folic acid-targeted magnetic Tb-doped CeF3 fluorescent nanoparticles as bimodal probes for cellular fluorescence and magnetic resonance imaging. Dalton Trans 44(37):16304–1631210.1039/C5DT01984B ↗
33. Maity AR, Saha A, Roy A et al (2013) Folic acid functionalized nanoprobes for fluorescence-, dark-field-, and dual-imaging-based selective detection of cancer cells and tissue. ChemPlusChem 78(3):259–26710.1002/cplu.201200296 ↗
34. Miao Y, Zhang Z, Gong Y et al (2014) Phosphorescent quantum dots/doxorubicin nanohybrids based on photoinduced electron transfer for detection of DNA. Biosens Bioelectron 59:300–30610.1016/j.bios.2014.03.076 ↗
35. Pan Y, Zhao Q, Li S et al (2014) Fluorescent-magnetic nanocomposites grafted with mannose derivatives: preparation, characterization, and bioapplication. J Nanopart Res 16(4)10.1007/s11051-013-1819-7 ↗
36. Rashidi LH, Homayoni H, Chen W (2014) Nanoparticle applications and targeting strategies in cancer diagnosis and treatment. Reviews in Nanoscience and Nanotechnology 3(1):31–5110.1166/rnn.2014.1044 ↗
37. Riani P, Napoletano M, Canepa F (2011) Synthesis, characterization and a.c. magnetic analysis of magnetite nanoparticles. J Nanopart Res 13(12):7013–702010.1007/s11051-011-0613-7 ↗
38. Shen M, Jia W, Lin C et al (2014) Facile synthesis of folate-conjugated magnetic/fluorescent bifunctional microspheres. Nanoscale Res Lett 9(1):55810.1186/1556-276X-9-558 ↗
39. Shen J, Li Y, Zhu Y et al (2015) Multifunctional gadolinium-labeled silica-coated Fe3O4 and CuInS2 nanoparticles as a platform for in vivo tri-modality magnetic resonance and fluorescence imaging. J Mater Chem B 3(14):2873–288210.1039/C5TB00041F ↗
40. Sun H, Wang M, Wang J et al (2015) Development of magnetic separation and quantum dots labeled immunoassay for the detection of mercury in biological samples. Journal of Trace Elements in Medicine and Biology 30:37–4210.1016/j.jtemb.2015.01.009 ↗
41. Supokawej A, Nimsanor N, Sanvoranart T et al (2015) Mesenchymal stem cell in vitro labeling by hybrid fluorescent magnetic polymeric particles for application in cell tracking. Medical Molecular Morphology 48(4):204–21310.1007/s00795-015-0102-7 ↗
42. Takahashi M, Mohan P, Nakade A et al (2015) Ag/FeCo/Ag core/shell/shell magnetic nanoparticles with plasmonic imaging capability. Langmuir 31(7):2228–223610.1021/la5046805 ↗
43. Tsai HY, Chang CY, Li YC et al (2010) Detection of carcinoembryonic antigen using functional magnetic and fluorescent nanoparticles in magnetic separators. J Nanopart Res 13(6):2461–246710.1007/s11051-010-0138-5 ↗
44. Vasquez ES, Feugang JM, Willard ST et al (2016) Bioluminescent magnetic nanoparticles as potential imaging agents for mammalian spermatozoa. Journal of Nanobiotechnology 14:2010.1186/s12951-016-0168-y ↗
45. Wang J, Qiu J (2016) A review of carbon dots in biological applications. J Mater Sci 51(10):4728–473810.1007/s10853-016-9797-7 ↗
46. Wang G, Su X (2011) The synthesis and bio-applications of magnetic and fluorescent bifunctional composite nanoparticles. Analyst 136:1783–179810.1039/c1an15036g ↗
47. Wang G, Gao Y, Huang H et al (2010a) Multiplex immunoassays of equine virus based on fluorescent encoded magnetic composite nanoparticles. Anal Bioanal Chem 398(2):805–81310.1007/s00216-010-4001-4 ↗
48. Wang G, Xie P, Xiao C et al (2010b) Magnetic fluorescent composite nanoparticles for the fluoroimmunoassays of Newcastle disease virus and avian virus arthritis virus. J Fluoresc 20(2):499–50610.1007/s10895-009-0573-9 ↗
49. Wang K, Ruan J, Qian Q et al (2011) BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer. Journal of Nanobiotechnology 9:2310.1186/1477-3155-9-23 ↗
50. Wang C, Ravi S, Garapati US et al (2013) Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents. Journal of Materials Chemistry. B, Materials for Biology and Medicine 1(35):4396–440510.1039/c3tb20452a ↗
51. Wang C, Bao C, Liang S et al (2014) HAI-178 antibody-conjugated fluorescent magnetic nanoparticles for targeted imaging and simultaneous therapy of gastric cancer. Nanoscale Res Lett 9(1):27410.1186/1556-276X-9-274 ↗
52. Wang G, Zhang X, Liu Y et al (2015) Magneto-fluorescent nanoparticles with high-intensity NIR emission, T1- and T2-weighted MR for multimodal specific tumor imaging. J Mater Chem B 3(15):3072–308010.1039/C5TB00155B ↗
53. Wang S, Li W, Yuan D et al (2016a) Quantitative detection of the tumor-associated antigen large external antigen in colorectal cancer tissues and cells using quantum dot probe. Int J Nanomedicine 11:235–24710.2217/nnm.15.193 ↗
54. Wang J, Wang F, Li F et al (2016b) A multifunctional poly(curcumin) nanomedicine for dual-modal targeted delivery, intracellular responsive release, dual-drug treatment and imaging of multidrug resistant cancer cells. Journal of Materials Chemistry. B, Materials for Biology and Medicine 4(17):2954–296210.1039/C5TB02450A ↗
55. Wegner KD, Hildebrandt N (2015) Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors. Chem Soc Rev 44(14):4792–483410.1039/C4CS00532E ↗
56. Wen CY, Xie HY, Zhang ZL et al (2016) Fluorescent/magnetic micro/nano-spheres based on quantum dots and/or magnetic nanoparticles: preparation, properties, and their applications in cancer studies. Nano 8(25):12406–12429
57. Wu X, Han Z, Schur RM et al (2016) Targeted mesoporous silica nanoparticles delivering arsenic trioxide with environment sensitive drug release for effective treatment of triple negative breast cancer. ACS Biomaterials Science & Engineering 2(4):501–50710.1021/acsbiomaterials.5b00398 ↗
58. Xing X, Zhang B, Wang X et al (2015) An “imaging-biopsy” strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. Biomaterials 48:16–2510.1016/j.biomaterials.2015.01.011 ↗
59. Yang H, Li Y, Li T et al (2014) Multifunctional core/shell nanoparticles cross-linked polyetherimide-folic acid as efficient Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports 4:707210.1038/srep07072 ↗
60. Yin C, Hong B, Gong Z et al (2015) Fluorescent oligo(p-phenyleneethynylene) contained amphiphiles-encapsulated magnetic nanoparticles for targeted magnetic resonance and two-photon optical imaging in vitro and in vivo. Nano 7(19):8907–8919
61. Yu S, Gao X, Baigude H et al (2015) Inorganic nanovehicle for potential targeted drug delivery to tumor cells, tumor optical imaging. ACS Appl Mater Interfaces 7(9):5089–509610.1021/am507345j ↗
62. Zhang Y, Shen Y, Teng X et al (2015) Mitochondria-targeting nanoplatform with fluorescent carbon dots for long time imaging and magnetic field-enhanced cellular uptake. ACS Appl Mater Interfaces 7(19):10201–1021210.1021/acsami.5b00405 ↗