Preparation and characterizations of naproxen-loaded magnetic nanoparticles coated with PLA-g-chitosan copolymer
Source abstract
Abstract
Naproxen (NPX) drug-loaded magnetic nanoparticles (MNPs) have been prepared in a one-step process utilizing a biocompatible polylactide-grafted-chitosan copolymer. The copolymer serves both as a NPX drug carrier as well as a polymeric surfactant for the synthesis of MNPs without the use of any additional surfactant. Highly stable MNPs with high magnetization in the form of maghemite (γ-Fe2O3) are prepared in aqueous media. Effects of preparation conditions on structures and properties of the copolymer-coated and drug-loaded MNPs are investigated by employing particle size and zeta potential measurements, transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction, Fourier-transform infrared, nuclear magnetic resonance, and confocal Raman spectroscopy. The results show that average particle size (150–300 nm), coating efficiency, and coating structures of the resulting MNPs materials are strongly dependent on MNP/copolymer and MNP/NPX ratios in feed. It is also observed that NPX acts as co-surfactant in the drug-loading process, resulting in different encapsulating structures with the variation in the MNP/copolymer and MNP/NPX ratios. Properties of the MNPs materials can be further optimized for use in specific biomedical applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · biodegradable polymer synthesis and properties · Nanocomposite Films for Food Packaging
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
Show source-provided references
1. Arol AI, Aydogan A (2004) Recovery enhancement of magnetite fines in magnetic separation. Colloids Surf A 232(2–3):151–15410.1016/j.colsurfa.2003.06.003 ↗
2. Chairam S, Somsook E (2008) Starch vermicelli template for synthesis of magnetic iron oxide nanoclusters. J Magn Magn Mater 320(15):2039–204310.1016/j.jmmm.2008.02.168 ↗
3. Chen M, Kim YN, Li C, Cho SO (2008) Preparation and characterization of magnetic nanoparticles and their silica egg-yolk-like nanostructures: a prospective multifunctional nanostructure platform. J Phys Chem C 112(17):6710–6716. doi: 10.1021/jp710775j10.1021/jp710775j ↗
4. Cocero MJ, Martín Á, Mattea F, Varona S (2009) Encapsulation and co-precipitation processes with supercritical fluids: fundamentals and applications. J Supercrit Fluids 47(3):546–55510.1016/j.supflu.2008.08.015 ↗
5. Coleman MM, Graf JF, Painter PC (1991) Specific interactions and the miscibility of polymer blends. Technomic Pub. Co, Lancaster
6. Cornell RM, Schwertmann U (2003) The iron oxides: structure, properties, reactions, occurrences and uses. Wiley-VCH, Weinheim10.1002/3527602097 ↗
7. Daou TJ, Grenèche JM, Pourroy G, Buathong S, Derory A, Ulhaq-Bouillet C, Donnio B, Guillon D, Begin-Colin S (2008) Coupling agent effect on magnetic properties of functionalized magnetite-based nanoparticles. Chem Mater 20(18):5869–5875. doi: 10.1021/cm801405n10.1021/cm801405n ↗
8. Espartero JL, Rashkov I, Li SM, Manolova N, Vert M (1996) NMR analysis of low molecular weight poly(lactic acid)s. Macromolecules 29(10):3535–3539. doi: 10.1021/ma950529u10.1021/ma950529u ↗
9. Feng H, Dong C-M (2006) Preparation, characterization, and self-assembled properties of biodegradable chitosan–poly(l-lactide) hybrid amphiphiles. Biomacromolecules 7(11):3069–3075. doi: 10.1021/bm060568l10.1021/bm060568l ↗
10. Garlotta D (2001) A literature review of poly(lactic acid). J Polym Environ 9(2):63–84. doi: 10.1023/a:102020082243510.1023/A:1020200822435 ↗
11. Guardia P, Batlle-Brugal B, Roca AG, Iglesias O, Morales MP, Serna CJ, Labarta A, Batlle X (2007) Surfactant effects in magnetite nanoparticles of controlled size. J Magn Magn Mater 316 (2 special issue):e756–e759. doi: 10.1016/j.jmmm.2007.03.08510.1016/j.jmmm.2007.03.085 ↗
12. Haneda K, Morrish AH (1976) Magnetite to maghemite transformation in ultrafine particles. J Phys Colloq 38:321–323
13. Iida H, Takayanagi K, Nakanishi T, Osaka T (2007) Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis. J Colloid Interface Sci 314(1):274–280. doi: 10.1016/j.jcis.2007.05.04710.1016/j.jcis.2007.05.047 ↗
14. Itoh H, Sugimoto T (2003) Systematic control of size, shape, structure, and magnetic properties of uniform magnetite and maghemite particles. J Colloid Interface Sci 265(2):283–295. doi: 10.1016/s0021-9797(03)00511-310.1016/S0021-9797(03)00511-3 ↗
15. Jang MK, Nah JW (2003) Characterization and modification of low molecular water-soluble chitosan for pharmaceutical application. Bull Korean Chem Soc 24:1303–130710.5012/bkcs.2003.24.9.1303 ↗
16. Jayakumar R, Menon D, Manzoor K, Nair SV, Tamura H (2010) Biomedical applications of chitin and chitosan based nanomaterials—a short review. Carbohydr Polym 82(2):227–232. doi: 10.1016/j.carbpol.2010.04.07410.1016/j.carbpol.2010.04.074 ↗
17. Khaleel AA (2004) Nanostructured pure γ-Fe2O3 via forced precipitation in an organic solvent. Chem Eur J 10(4):925–932. doi: 10.1002/chem.20030513510.1002/chem.200305135 ↗
18. Kim DK, Mikhaylova M, Zhang Y, Muhammed M (2003) Protective coating of superparamagnetic iron oxide nanoparticles. Chem Mater 15(8):1617–1627. doi: 10.1021/cm021349j10.1021/cm021349j ↗
19. Kim JS, Yoon T-J, Yu KN, Kim BG, Park SJ, Kim HW, Lee KH, Park SB, Lee J-K, Cho MH (2006) Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 89(1):338–347. doi: 10.1093/toxsci/kfj02710.1093/toxsci/kfj027 ↗
20. Legodi MA, de Waal D (2007) The preparation of magnetite, goethite, hematite and maghemite of pigment quality from mill scale iron waste. Dyes Pigment 74(1):161–16810.1016/j.dyepig.2006.01.038 ↗
21. Liao H, Chen D, Yuan L, Zheng M, Zhu Y, Liu X (2010) Immobilized cellulase by polyvinyl alcohol/Fe2O3 magnetic nanoparticle to degrade microcrystalline cellulose. Carbohydr Polym 82(3):600–604. doi: 10.1016/j.carbpol.2010.05.02110.1016/j.carbpol.2010.05.021 ↗
22. Lin C-L, Lee C-F, Chiu W-Y (2005) Preparation and properties of poly(acrylic acid) oligomer stabilized superparamagnetic ferrofluid. J Colloid Interface Sci 291(2):411–42010.1016/j.jcis.2005.05.023 ↗
23. Lübbe AS, Alexiou C, Bergemann C (2001) Clinical applications of magnetic drug targeting. J Surg Res 95(2):200–20610.1006/jsre.2000.6030 ↗
24. Matutes-Aquino J, García-Casillas P, Ayala-Valenzuela O, García-García S (1999) Study of iron oxides obtained by decomposition of an organic precursor. Mater Lett 38(3):173–17710.1016/S0167-577X(98)00154-2 ↗
25. Mikhaylova M, Kim DK, Bobrysheva N, Osmolowsky M, Semenov V, Tsakalakos T, Muhammed M (2004) Superparamagnetism of magnetite nanoparticles: dependence on surface modification. Langmuir 20(6):2472–2477. doi: 10.1021/la035648e10.1021/la035648e ↗
26. Mura P, Zerrouk N, Mennini N, Maestrelli F, Chemtob C (2003) Development and characterization of naproxen–chitosan solid systems with improved drug dissolution properties. Eur J Pharm Sci 19(1):67–7510.1016/S0928-0987(03)00068-X ↗
27. Narang AS, Delmarre D, Gao D (2007) Stable drug encapsulation in micelles and microemulsions. Int J Pharm 345:9–2510.1016/j.ijpharm.2007.08.057 ↗
28. Opaprakasit P, Opaprakasit M (2008) Thermal properties and crystallization behaviors of polylactide and its enantiomeric blends. Macromol Symp 264(1):113–12010.1002/masy.200850418 ↗
29. Opaprakasit P, Opaprakasit M, Tangboriboonrat P (2007) Crystallization of polylactide and its stereocomplex investigated by two-dimensional Fourier transform infrared correlation spectroscopy employing carbonyl overtones. Appl Spectrosc 61(12):1352–135810.1366/000370207783292235 ↗
30. Paramês ML, Viskadourakis Z, Rogalski MS, Mariano J, Popovici N, Giapintzakis J, Conde O (2007) Magnetic properties of Fe3O4 thin films grown on different substrates by laser ablation. Appl Surf Sci 253(19):8201–820510.1016/j.apsusc.2007.02.134 ↗
31. Qu S, Wang J, Kong J, Yang P, Chen G (2007) Magnetic loading of carbon nanotube/nano-Fe3O4 composite for electrochemical sensing. Talanta 71(3):1096–110210.1016/j.talanta.2006.06.003 ↗
32. Roca AG, Marco JF, Del Puerto Morales M, Serna CJ (2007) Effect of nature and particle size on properties of uniform magnetite and maghemite nanoparticles. J Phys Chem C 111(50):18577–1858410.1021/jp075133m ↗
33. Sinha VR, Singla AK, Wadhawan S, Kaushik R, Kumria R, Bansal K, Dhawan S (2004) Chitosan microspheres as a potential carrier for drugs. Int J Pharm 274(1–2):1–33
34. Socrates G (1994) Infrared characteristic group frequencies: tables and charts, 2nd edn. Wiley, Chichester
35. Sun J, Zhou S, Hou P, Yang Y, Weng J, Li X, Li M (2007) Synthesis and characterization of biocompatible Fe3O4 nanoparticles. J Biomed Mater Res Part A 80A(2):333–341. doi: 10.1002/jbm.a.3090910.1002/jbm.a.30909 ↗
36. Teja AS, Koh P-Y (2009) Synthesis, properties, and applications of magnetic iron oxide nanoparticles. Prog Cryst Growth Charact Mater 55(1–2):22–4510.1016/j.pcrysgrow.2008.08.003 ↗
37. Wu Y, Li M, Gao H (2009) Polymeric micelle composed of PLA and chitosan as a drug carrier. J Polym Res 16(1):11–18. doi: 10.1007/s10965-008-9197-z10.1007/s10965-008-9197-z ↗
38. Zhang D, Tong Z, Li S, Zhang X, Ying A (2008) Fabrication and characterization of hollow Fe3O4 nanospheres in a microemulsion. Mater Lett 62(24):4053–405510.1016/j.matlet.2008.05.023 ↗