Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery
Source abstract
Abstract
In this study, we presented a simple approach to prepare hydroxyethylated graphene oxide (HE-GO) with high water solubility and physiological stability. The successful synthesis of HE-GO was confirmed by UV–Vis spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The loading of anticancer drug methotrexate (MTX) onto this nanocarrier (MTX/HE-GO) was investigated. The results of in vitro drug release experiment showed that the rate of MTX release from MTX/HE-GO was pH dependent. Moreover, cell viability assay demonstrated that HE-GO loaded with MTX exhibits higher anticancer activity against human lung adenocarcinoma epithelial cell line than non-vehicle MTX.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticle-Based Drug Delivery · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (24)
Show source-provided references
1. Chen S, Wu G, Chen D (2006) An easy approach to hydroxyethylated SWNTs and the high thermal stability of the inner grafted hydroxyethyl groups. Nanotechnology 17:2368–237210.1088/0957-4484/17/9/048 ↗
2. Choucair A, Soo PL, Eisenberg A (2005) Active loading and tunable release of doxorubicin from block copolymer vesicles. Langmuir 21:9308–931310.1021/la050710o ↗
3. Fan JQ, Fang G, Wang XD, Zeng F, Xiang YF, Wu SZ (2011) Targeted anticancer prodrug with mesoporous silica nanoparticles as vehicles. Nanotechnology 22:45510210.1088/0957-4484/22/45/455102 ↗
4. Gillies ER, Frechet JM (2005) pH-Responsive copolymer assemblies for controlled release of doxorubicin. Bioconjug Chem 16:361–36810.1021/bc049851c ↗
5. Grim J, Chládek J, Martínková J (2003) Pharmacokinetics and pharmacodynamics of methotrexate in non-neoplastic diseases. Clin Pharmacokinet 42(2):139–15110.2165/00003088-200342020-00003 ↗
6. Hummers WS, Offeman RE (1958) Preparation of Graphitic Oxide. J Am Chem Soc 80:133910.1021/ja01539a017 ↗
7. Jiao L, Zhang L, Wang X, Diankov G, Dai H (2009) Narrow graphene nanoribbons from carbon nanotubes. Nature 458:877–88010.1038/nature07919 ↗
8. Kakran M, Sahoo NG, Bao H, Pan Y, Li L (2011) Functionalized graphene oxide as nanocarrier for loading and delivery of ellagic acid. Curr Med Chem 18:4503–451210.2174/092986711797287548 ↗
9. Kim H, Namgung R, Singha K, Oh IK, Kim WJ (2011) Graphene oxide-polyethylenimine nanoconstruct as a gene delivery vector and bioimaging tool. Bioconjug Chem 22:2558–256710.1021/bc200397j ↗
10. Liao KH, Lin YS, Macosko CW, Haynes CL (2011) Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts. ACS Appl Mater Interfaces 3:2607–261510.1021/am200428v ↗
11. Liu Z, Robinson JT, Sun XM, Dai HJ (2008) PEGylated nano-graphene oxide for delivery of water insoluble cancer drugs. J Am Chem Soc 130:10876–1087710.1021/ja803688x ↗
12. Lu YH, Yang XY, Ma YF, Huang Y, Chen YS (2008) A novel nanohybrid of daunomycin and single-walled carbon nanotubes: photophysical properties and enhanced electrochemical activity. Biotechnol Lett 30:1031–103510.1007/s10529-008-9641-5 ↗
13. Lu CH, Li J, Liu JJ, Yang HH, Chen X, Chen GN (2010) Increasing the sensitivity and single-base mismatch selectivity of the molecular beacon using graphene Oxide as the “nanoquencher”. Chem Eur J 16:4889–489410.1002/chem.200903071 ↗
14. Murakami T, Ajima K, Miyawaki J, Yudasaka M, Iijima S, Shiba K (2004) Drug-loaded carbon nanohorns: adsorption and release of dexamethasone in vitro. Mol Pharm 1:399–40510.1021/mp049928e ↗
15. Petit C, Seredych M, Bandosz TJ (2009) Revisting the chemistry of graphite oxide and its effect on ammonia adsorption. J Mater Chem 19:9176–918510.1039/b916672f ↗
16. Sahoo NG, Bao H, Pan Y, Pal M, Kakran M, Cheng HKF, Li L, Tan LP (2011) Functionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study. Chem Commun 47:5235–523710.1039/c1cc00075f ↗
17. Santos MA, Enyedy EA, Nuti E, Rossello A, Krupenko NI, Krupenko SA (2007) Methotrexate gamma-hydroxamate derivatives as potential dual target antitumor drugs. Bioorg Med Chem 15:1266–127410.1016/j.bmc.2006.11.017 ↗
18. Shen H, Liu M, He H, Zhang L, Huang J, Chong Y, Dai J, Zhang Z (2012) PEGylated graphene oxide-mediated protein delivery for cell function regulation. ACS Appl Mater Interfaces 4:6317–632310.1021/am3019367 ↗
19. Sun X, Liu Z, Welsher K, Robinson JT, Goodwin A, Zaric S, Dai H (2008) Nano-graphene oxide for cellular imaging and drug delivery. Nano Res 1:203–21210.1007/s12274-008-8021-8 ↗
20. Wu J, Wang YS, Yang XY, Liu YY, Yang JR, Yang R, Zhang N (2012) Graphene oxide used as carrier for adriamycin can reverse drug resistance in breast cancer cells. Nanotechnology 23(35):35510110.1088/0957-4484/23/35/355101 ↗
21. Yang XY, Zhang XY, Liu ZF, Ma YF, Huang Y, Chen YS (2008) High-efficiency loading and controlled release of doxorubicin hydrochloride on graphene oxide. J Phys Chem C 112:17554–1755810.1021/jp806751k ↗
22. Yang J, Yan X, Wu M, Chen F, Fei Z, Zhong M (2012) Self-assembly between graphene sheets and cationic poly(methyl methacrylate) (PMMA) particles: preparation and characterization of PMMA/graphene composites. J Nanopart Res 14:71710.1007/s11051-011-0717-0 ↗
23. Zhang LM, Xia JG, Zhao QH, Liu LW, Zhang ZJ (2010) Functional graphene oxide as nanocarriers for controlled loading and targeted delivery of mixed anticancer drugs. Small 6:537–54410.1002/smll.200901680 ↗
24. Zhu S, Li J, Chen Y, Chen Z, Chen C, Li Y, Cui Z, Zhang D (2012) Grafting of graphene oxide with stimuli-responsive polymers by using ATRP for drug release. J Nanopart Res 14:113210.1007/s11051-012-1132-x ↗