Synthesis and characterization of mesoporous and hollow-mesoporous MxFe3-xO4 (M=Mg, Mn, Fe, Co, Ni, Cu, Zn) microspheres for microwave-triggered controllable drug delivery
Source abstract
Abstract
Spinel ferrites can be used in magnetic targeting and microwave heating and can therefore be used for targeted and controllable drug delivery. We used the cetyltrimethylammonium bromide-assisted solvothermal method to synthesize a series of spinel ferrites (MxFe3-xO4, M=Mg, Mn, Fe, Co, Ni, Cu, Zn) with a mesoporous or hollow-mesoporous structure suitable for direct drug loading and the particle diameters ranging from 200 to 350 nm. We investigated the effects of M2+ cation on the morphology and properties of these products by analyzing their transmission electron microscopy images, mesoporous properties, magnetic properties, and microwave responses. We chose hollow-mesoporous MxFe3-xO4 (M=Fe, Co, Zn) nanoparticles, which had better overall properties, for the drug VP16 (etoposide) loading and microwave-controlled release. The CoxFe3-xO4 and Fe3O4 particles trapped 61.5 and 64.8%, respectively, of the VP16, which were higher than that (60.4%) of ZnxFe3-xO4. Controllable drug release by these simple magnetic nanocarriers can be achieved by microwave irradiation, and VP16-loaded CoxFe3-xO4 released the most VP16 molecules (more than 50% after 1 h and 69.1% after 6 h) under microwave irradiation. Our results confirm the favorable drug loading and microwave-controlled delivery by these ferrites, and lay a theoretical foundation to promote clinical application of the targeted controllable drug delivery system.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanomaterials for catalytic reactions · Magnetic Properties and Synthesis of Ferrites · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (35)
Show source-provided references
1. Barreto ACH, Santiago VR, Mazzetto SE, Denardin JC, Lavín R, Mele G, Ribeiro MENP, Vieira IGP, Gonçalves T, Ricardo NMPS, Fechine PBA (2011) Magnetic nanoparticles for a new drug delivery system to control quercetin releasing for cancer chemotherapy. J Nanopart Res 19:6545–6553. https://doi.org/10.1007/s11051-011- 0559-910.1007/s11051-011- 0559-9 ↗
2. Cao F, Deng RP, Tang JK, Song SY, Lei YQ, Zhang HJ (2011) Cobalt and nickel with various morphologies: mineralizer-assisted synthesis, formation mechanism, and magnetic properties. CrystEngComm 13(1):223–229. https://doi.org/10.1039/c0ce00074d10.1039/c0ce00074d ↗
3. Chen P, Cui B, Cui XR, Zhao WW, Bu YM, Wang YY (2017) A microwave-triggered controllable drug delivery system based on hollow-mesoporous cobalt ferrite magnetic nanoparticles. J Alloys Compd 699:526–533. https://doi.org/10.1016/j.jallcom. 2016.12.30410.1016/j.jallcom. 2016.12.304 ↗
4. Chun JY, Seo SW, Jung GY, Jee J (2011) Easy access to efficient magnetically recyclable separation of histidine-tagged proteins using superparamagnetic nickel ferrite nanoparticle clusters. J Mater Chem 21(18):6713–6717. https://doi.org/10.1039/ c0jm04089d10.1039/ c0jm04089d ↗
5. Deng H, Li XL, Peng Q, Wang X, Chen JP, Li YD (2005) Monodisperse magnetic single-crystal ferrite microspheres. Angew Chem Int Ed 44(18):2782–2785. https://doi.org/10.1002/anie.20046255110.1002/anie.200462551 ↗
6. Deng H, Chen HY, Li H (2007) Synthesis of crystal MFe2O4 (M=Mg, Cu, Ni) microspheres. Mater Chem Phys 101(2–3):509–513. https://doi.org/10.1016/j.matchemphys. 2006.10.00210.1016/j.matchemphys. 2006.10.002 ↗
7. Fan WJ, Li X, Zhang L, Jiang H, Zhang JL (2012) Comparison of microwave ablation and multipolar radiofrequency ablation in vivo using two internally cooled probes. Am J Roentgenol 198(1):46–50. https://doi.org/10.2214/AJR.11.670710.2214/AJR.11.6707 ↗
8. Fang XL, Zhao XJ, Fang WJ, Chen C, Zheng NF (2013) Self-templating synthesis of hollow mesoporous silica and their applications in catalysis and drug delivery. Nano 5(6):2205–2218. https://doi.org/10.1039/c3nr34006f10.1039/c3nr34006f ↗
9. Fannin PC, Marin CN, Malaescu I, Stefu N, Vlăzan P, Novaconi S, Popescu SS (2011) Effect of the concentration of precursors on the microwave absorbent properties of Zn/Fe oxide nanopowders. J Nanopart Res 13(1):311–319. https://doi.org/10.1007/s11051- 010-0032-110.1007/s11051- 010-0032-1 ↗
10. Faraji M, Yamini Y, Rezaee M (2010) Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization, and applications. J Iran Chem Soc 7(1):1–37. https://doi.org/10.1007/bf0324585610.1007/bf03245856 ↗
11. Hammad M, Nica V, Hempelmann R (2016) On-off switch-controlled doxorubicin release from thermo- and pH-responsive coated bimagnetic nanocarriers. J Nanopart Res 18(8):234–246. https://doi.org/10.1007/s11051-016-3550-710.1007/s11051-016-3550-7 ↗
12. Han Z, Li D, Liu XG, Geng DY, Li J, Zhang ZD (2009) Microwave-absorption properties of Fe(Mn)/ferrite nanocapsules. J Phys D Appl Phys 42(5):55008–55012. https://doi.org/10.1088/0022-3727/42/5/05500810.1088/0022-3727/42/5/055008 ↗
13. Hervault A, Thanh N (2014) Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer. Nano 6(20):11553–11573. https://doi.org/10.1039/c4nr03482a10.1039/c4nr03482a ↗
14. Jin YS, Liang XL, An YK, Dai ZF (2016) Microwave-triggered smart drug release from liposomes co-encapsulating doxorubicin and salt for local combined hyperthermia and chemotherapy of cancer. Bioconjug Chem 27(12):2931–2942. https://doi.org/10.1021/acs.bioconjchem.6b0060310.1021/acs.bioconjchem.6b00603 ↗
15. Li YN, Wu T, Jiang KD, Tong GX, Jin KY, Qian NX, Zhao LH, Lv TX (2016) Mn2+ induced structure evolution and dual-frequency microwave absorption of MnxFe3-xO4 hollow/porous spherical chains made by a one-pot solvothermal approach. J Mater Chem C 4(29):7119–7129. https://doi.org/10.1039/c6tc01900e10.1039/c6tc01900e ↗
16. Liu WJ, Zhu FL, Liu YX, Xu YP, Liu SM (2015) One-pot synthesis of hollow mesoporous carbon materials and their drug release properties. J Mater Sci 50(2):717–724. https://doi.org/10.1007/s10853-014-8631-310.1007/s10853-014-8631-3 ↗
17. Lu AH, Salabas EL, Schiith F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed 46(8):1222–1244. https://doi.org/10.1002/anie.20060286610.1002/anie.200602866 ↗
18. Mody VV, Cox A, Shah S, Singh A, Bevins W, Parihar H (2014) Magnetic nanoparticle drug delivery systems for targeting tumor. Appl Nanosci 4(4):385–392. https://doi.org/10.1007/s13204-013-0216-y10.1007/s13204-013-0216-y ↗
19. Mohapatra S, Rout SR, Narayan R, Maiti TK (2014) Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging. Dalton Trans 43(42):15841–15850. https://doi.org/10.1039/c4dt02144d10.1039/c4dt02144d ↗
20. Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12(11):991–1003. https://doi.org/10.1038/nmat377610.1038/nmat3776 ↗
21. Niescioruk A, Nieciecka D, Puszko AK, Królikowska A, Kosson P, Perret GY, Krysinski P, Misicka A (2017) Physicochemical properties and in vitro cytotoxicity of iron oxide-based nanoparticles modified with antiangiogenic and antitumor peptide A7R. J Nanopart Res 19(5):160–172. https://doi.org/10.1007/s11051-017- 3859-x10.1007/s11051-017- 3859-x ↗
22. Shi HT, Liu TL, Fu CH, Li LL, Tan LF, Wang JZ, Ren XL, Ren J, Wang JX, Meng XL (2015) Insights into a microwave susceptible agent for minimally invasive microwave tumor thermal therapy. Biomaterials 44:91–102. https://doi.org/10.1016/ j.biomaterials.2014.12.03510.1016/ j.biomaterials.2014.12.035 ↗
23. Sun TM, Zhang YS, Pang B, Hyun DC, Yang MX, Xia YN (2014) Engineered nanoparticles for drug delivery in cancer therapy. Angew Chem Int Ed 53:12320–12364. https://doi.org/10.1002/anie.20140303610.1002/anie.201403036 ↗
24. Tao CL, Zhu YF (2014) Magnetic mesoporous silica nanoparticles for potential delivery of chemotherapeutic drugs and hyperthermia. Dalton Trans 43(41):15482–15490. https://doi.org/10.1039/c4dt01984a10.1039/c4dt01984a ↗
25. Wang CP, Li CH, Bi H, Li JC, Zhang H, Xie AJ, Shen YH (2014) Novel one-dimensional polyaniline/Ni0.5Zn0.5Fe2O4 hybrid nanostructure: synthesis, magnetic, and electromagnetic wave absorption properties. J Nanopart Res 16(3):2289–2300. https://doi.org/10.1007/s11051-014-2289-210.1007/s11051-014-2289-2 ↗
26. Widder KJ, Senyel AE, Scarpelli GD (1978) Magnetic microspheres: a model system of site specific drug delivery in vivo. Exp Biol Med 158(2):141–146. https://doi.org/10.1063/ 1.32521910.1063/ 1.325219 ↗
27. Xu R, Sun GY, Li QY, Wang EB, Gu JM (2010) A dual-responsive superparamagnetic Fe3O4/silica/PAH/PSS material used for controlled release of chemotherapeutic agent, keggin poly-oxotungstate, PM-19. Solid State Sci 12(10):1720–1725. https://doi.org/10.1016/j.solidstatesciences.2010.06.02610.1016/j.solidstatesciences.2010.06.026 ↗
28. Xu JJ, Liu JW, Che CR, Liang CY, Cao MS, Li Y, Liu ZW (2014) Polarization enhancement of microwave absorption by increasing aspect ratio of ellipsoidal nanorattles with Fe3O4 cores and hierarchical CuSiO3 shells. Nano 6(11):5782–5790. https://doi.org/10.1039/c4nr00158c10.1039/c4nr00158c ↗
29. Xu YY, Sun DD, Hao HY, Gao DZ, Sun YQ (2016) Non-stoichiometric Co(II), Ni(II), Zn(II)-ferrite nanospheres: size controllable synthesis, excellent gas-sensing and magnetic properties. RSC Adv 6(101):98994–99002. https://doi.org/10.1039/c6ra21990j10.1039/c6ra21990j ↗
30. Yang CY, Guo W, Cui LR, An N, Zhang T, Lin HM, Qu FY (2014) pH-responsive magnetic core-shell nanocomposites for drug delivery. Langmuir 30(32):9819–9827. https://doi.org/10.1021/la501833u10.1021/la501833u ↗
31. Yang LX, Xu YB, Jin RC, Wang F, Yin P, Li GH, Xu CP, Pan LB (2015) Nonstoichiometric M-ferrite porous spheres: preparation, shape evolution and magnetic properties. Ceram Int 41(2):2309–2317. https://doi.org/10.1016/j.ceramint.2014. 10.03710.1016/j.ceramint.2014. 10.037 ↗
32. Yin Y, Rioux RM, Erdonmez CK, Hughes S, Somorjai GA, Alivisatos AP (2004) Formation of hollow nanocrystals through the nanoscale Kirkendall effect. Science 304(5671):711–714. https://doi.org/10.1126/science.109656610.1126/science.1096566 ↗
33. Yu L, Wu HB, Lou XW (2017) Self-templated formation of hollow structures for electrochemical energy applications. Acc Chem Res 50(2):293–301. https://doi.org/10.1021/ acs.accounts.6b0048010.1021/ acs.accounts.6b00480 ↗
34. Zhao WW, Cui B, Peng HX, Qiu HJ, Wang YY (2015) Novel method to investigate the interaction force between etoposide and APTES-functionalized Fe3O4@nSiO2@mSiO2 nanocarrier for drug loading and release processes. J Phys Chem C 119(8):4379–4386. https://doi.org/10.1021/jp512447s10.1021/jp512447s ↗
35. Zhu MY, Meng DH, Wang CJ, Diao GW (2013) Facile fabrication of hierarchically porous CuFe2O4 nanospheres with enhanced capacitance property. ACS Appl Mater Inter 5(13):6030–6037. https://doi.org/10.1021/am400735310.1021/am4007353 ↗