Development of monodispersed and functional magnetic polymeric liposomes via simple liposome method
Source abstract
Abstract
We are reporting a simple and rapid method to prepare superparamagnetic, controlled size, and monodispersed magnetic cationic polymeric liposomes (MCPL) by octadecyl quaternized carboxymethyl chitosan (OQCMC) and cholesterol. The whole process is only about 25 min with simple thin-film dispersion and solvent evaporation method. Hydrophilic magnetic nanoparticles (LM) and hydrophobic magnetic nanoparticles (BM) can be encapsulated into these cationic polymeric liposomes, simultaneously or respectively. A model hydrophobic drug indomethacin can be successfully filled in MCPL with high drug loading capacity 22%. MCPL encapsulating BM also showed strong DNA (pEGFP) binding ability. Drug-loaded MCPL have a long and controlled sustained release profile by changing the number of polymeric lipid layer. These functional MCPL nanospheres can be allowed to serve as ideal candidates for many biomedical applications. A simple and rapid liposome method was reported to prepare superparamagnetic, controlled size, and monodispersed magnetic cationic polymeric liposomes (MCPL) by polymeric surfactant, octadecyl quaternized carboxymethyl chitosan (OQCMC), and cholesterol. Hydrophilic Fe3O4 ferrofluid and hydrophobic magnetic nanoparticles can be encapsulated into these cationic polymeric liposomes, simultaneously or respectively. Hydrophobic drug indomethacin can be encapsulated into this MCPL with high encapsulating efficiency and with controlled release profile by changing the number of polymeric lipid layer.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (27)
Show source-provided references
1. Chen MH, Kim YN, Li CC, Cho SO (2008) Preparation and characterization of magnetic nanoparticles and their silica egg-yolk-like nanostructures: a prospective multifunctional nanostructure platform. J Phys Chem C 112(17):6710–671610.1021/jp710775j ↗
2. Dennis C, Jamesa H (1985) Polymeric liposomes as stable gas carriers. European Patent WO8504326
3. Ewert KK, Evans HM, Zidovska A, Bouxsein NF, Ahmad A, Safinya CR (2006) A columnar phase of dendritic lipid-based cationic liposome-dna complexes for gene delivery: hexagonally ordered cylindrical micelles embedded in a DNA honeycomb lattice. J Am Chem Soc 128:3998–400610.1021/ja055907h ↗
4. Fan HY, Leve EW, Scullin C, Gabaldon J, Tallant D, Bunge S, Boyle T, Wilson MC, Brinker CJ (2005) Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot micelles. Nano Lett 5(4):645–64810.1021/nl050017l ↗
5. Gao JH, Zhang W, Huang PB, Zhang B, Zhang XX, Xu B (2008) Intracellular spatial control of fluorescent magnetic nanoparticles. J Am Chem Soc 130:3710–371110.1021/ja7103125 ↗
6. Gerelli Y, Bari MTD, Deriu A, Cantù L, Colombo P, Como C, Motta S, Sonvico F, May R (2008) Structure and organization of phospholipid/polysaccharide nanoparticles. J Phys Condens Matter 20:104211–10421910.1088/0953-8984/20/10/104211 ↗
7. Horák D, Babič M, Macková H, Beneš MJ (2007) Preparation and properties of magnetic nano- and microsized particles for biological and environmental separations. J Sep Sci 30(11):1751–177210.1002/jssc.200700088 ↗
8. Im SH, Herricks T, Lee YT, Xia Y (2005) Synthesis and characterization of monodisperse silica colloids loaded with superparamagnetic iron oxide nanoparticles. Chem Phys Lett 401(1–3):19–2310.1016/j.cplett.2004.11.028 ↗
9. Kim J, Lee JE, Lee J, Yu JH, Kim BC, An K, Wang YH, Shin CH, Park JG, Kim J, Hyeon T (2006) Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals. J Am Chem Soc 128:688–68910.1021/ja0565875 ↗
10. Kížová J, Španová A, Bohuslav R, Horák D (2005) Magnetic hydrophilic methacrylate-based polymer microspheres for genomic DNA isolation. J Chromatogr A 1064(2):247–25310.1016/j.chroma.2004.12.014 ↗
11. Krack M, Hohenberg H, Kornowski A, Lindner P, Weller H, Förster S (2008) Nanoparticle-loaded magnetophoretic vesicles. J Am Chem Soc 130:7315–732010.1021/ja077398k ↗
12. Kubo T, Sugita T, Shimose S, Nitta Y, Ikuta Y, Murakami T (2001) Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. Int J Oncol 18(1):121–125
13. Liang XF, Wang HJ, Luo H, Tian H, Zhang BB, Hao LJ, Teng JI, Chang J (2008a) Characterization of novel multifunctional cationic polymeric liposomes formed from octadecyl quaternized carboxymethyl chitosan/cholesterol and drug encapsulation. Langmuir 24(14):7147–715310.1021/la703775a ↗
14. Liang XF, Wang HJ, Tian H, Luo H, Chang J (2008b) Structure and properties of novel quaternized carboxymethyl chitosan with drug loading capacity. Acta Physico-Chimica Sinica 24(2):223–22910.1016/S1872-1508(08)60011-X ↗
15. Liang XF, Wang HJ, Tian H, Luo H, Cheng J, Han L, Chang J (2008c) Synthesis and characterization of novel magnetic cationic polymeric liposomes. Chem J Chin Univ 29(4):858–861
16. Liang XF, Tian H, Luo H, Wang HJ, Chang J (2009) Novel quaternized chitosan and polymeric micelles with cross-linked ionic cores for prolonged release. J Biomater Sci 20:115–13110.1163/156856208X393536 ↗
17. Liu C, Zou BS, Rondinone AJ, Zhang ZJ (2000) Reverse micelle synthesis and characterization of superparamagnetic MnFe2O4 spinel ferrite nanocrystallites. J Phys Chem B 104(6):1141–114510.1021/jp993552g ↗
18. Liu HB, Guo J, Jin L, Yang WL, Wang CC (2008) Fabrication and functionalization of dendritic poly(amidoamine)-immobilized magnetic polymer composite microspheres. J Phys Chem B 112:3315–332110.1021/jp077465x ↗
19. Lu Y, Yin YD, Mayers BT, Xia YN (2002) Modifying the surface properties of superparamagnetic iron oxide nanoparticles through a sol–gel approach. Nano Lett 2(3):183–18610.1021/nl015681q ↗
20. Sadasivan S, Sukhorukov GB (2006) Fabrication of hollow multifunctional spheres containing MCM-41 nanoparticles and magnetite nanoparticles using layer-by-layer method. J Colloid Interface Sci 304(2):437–44110.1016/j.jcis.2006.09.010 ↗
21. Stjerndahl M, Andersson M, Hall HE, Pajerowski DM, Meisel MW, Duran RS (2008) Superparamagnetic Fe3O4/SiO2 nanocomposites: enabling the tuning of both the iron oxide load and the size of the nanoparticles. Langmuir 24(7):3532–353610.1021/la7035604 ↗
22. Sun SH, Zeng H (2002) Size-controlled synthesis of magnetite nanoparticles. J Am Chem Soc 124:8204–820510.1021/ja026501x ↗
23. Sun SH, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li GX (2004) Monodisperse MFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc 126:273–27910.1021/ja0380852 ↗
24. Wang QB, Liu Y, Lin CX, Yan H (2007) Layer-by-layer growth of superparamagnetic, fluorescent barcode nanospheres. Nanotechnology 18(40):405604 (7 pp)10.1088/0957-4484/18/40/405604 ↗
25. Xu H, Cui LL, Tong NH, Gu HC (2006) Development of high magnetization Fe3O4/polystyrene/silica nanospheres via combined miniemulsion/emulsion polymerization. J Am Chem Soc 128:15582–1558310.1021/ja066165a ↗
26. Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J, Kobayashi T (1998) Intracellular hyperthermia for cancer using magnetite cationic liposomes: an in vivo study. Jpn J Cancer Res 89(4):463–46910.1111/j.1349-7006.1998.tb00586.x ↗
27. Yi DK, Selvan ST, Lee SS, Papaefthymiou GC, Kundaliya D, Ying JY (2005) Silica-coated nanocomposites of magnetic nanoparticles and quantum dots. J Am Chem Soc 127:4990–499110.1021/ja0428863 ↗