Comparison of cellular toxicity between multi-walled carbon nanotubes and onion-like shell-shaped carbon nanoparticles
Source abstract
Abstract
The cellular toxicity of multi-walled carbon nanotubes (MWCNTs) and onion-like shell-shaped carbon nanoparticles (SCNPs) was investigated by analyzing the comparative cell viability. For the reasonable comparison, physicochemical characteristics were controlled thoroughly such as crystallinity, carbon bonding characteristic, hydrodynamic diameter, and metal contents of the particles. To understand relation between cellular toxicity of the particles and generation of reactive oxygen species (ROS), we measured unpaired singlet electrons of the particles and intracellular ROS, and analyzed cellular toxicity with/without the antioxidant N-acetylcysteine (NAC). Regardless of the presence of NAC, the cellular toxicity of SCNPs was found to be lower than that of MWCNTs. Since both particles show similar crystallinity, hydrodynamic size, and Raman signal with negligible contribution of remnant metal particles, the difference in cell viability would be ascribed to the difference in morphology, i.e., spherical shape (aspect ratio of one) for SCNP and elongated shape (high aspect ratio) for MWCNT.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Carbon Nanotubes in Composites · Electrochemical Analysis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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