Anticancer potential of chalcones loaded on mesoporous silica nanoparticles
Source abstract
Abstract
Abstract The difficulty in treating cancer has led to several studies on the development of systems that perform targeted drug delivery, with the aim of increasing the effectiveness of treatment and reducing adverse effects. In this study, a series of chalcones were tested for cytotoxic action on gastric adenocarcinoma cells (AGS) and breast cancer cells (MCF-7) using the MTT-tetrazolium method, and significant cytotoxicity was demonstrated for 3-hydroxychalcone (CHO). The synthesis of mesoporous silica nanoparticles (MSNs) and their surface modification with 3-aminopropyltriethoxysilane (APTES) were carried out, and 3-hydroxychalcone was then incorporated into these nanomaterials. Mesoporous silica nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), elemental analysis (CHN), scanning electron microscopy (SEM), transmission electron microscopy (TEM), zeta potential and nitrogen adsorption. In addition, in vitro release tests were carried out to verify the release profile of 3-hydroxychalcone from mesoporous silica samples. The results obtained showed that the mesoporous silica nanoparticles exhibited a gradual and prolonged release profile. In the cytotoxicity test with silica samples incorporated with 3-hydroxychalcone, significant cytotoxic activity was observed against AGS and MCF-7 cells, with the MSN-CHO sample exhibiting a better cytotoxic effect (IC50 of 12.93 to 22.30 μM) than 3-hydroxychalcone (IC50 of 47.58 to 47.97 μM). The results showed that the nanoparticles positively influenced the interaction of 3-hydroxychalcone with tumor cells. This is therefore an unprecedented study on the incorporation of 3-hydroxychalcone into mesoporous silica nanoparticles and its promising results in terms of cytotoxic activity against breast and gastric cancer cells.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Synthesis and Characterization of Heterocyclic Compounds · Synthesis and biological activity
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (29)
Show source-provided references
1. Ouyang Y, Li J, Chen X, Fu X, Sun S, Wu Q (2021) Chalcone derivatives: role in anticancer therapy. Biomolecules 11(6):894. https://doi.org/10.3390/biom1106089410.3390/biom11060894 ↗
2. GLOBOCAN – The Global Cancer Observatory (2024) Cancer Today: IARC. https://gco.iarc.fr/today/en/dataviz/pie?mode=cancer&group_populations=1&types=0. Accessed 10 Feb 2024
3. Mansouri V, Beheshtizadeh N, Gharibshahian M, Sabouri L, Varzandeh M, Rezaei N (2021) Recent advances in regenerative medicine strategies for cancer treatment. Biomed Pharmacother 141:111875. https://doi.org/10.1016/j.biopha.2021.11187510.1016/j.biopha.2021.111875 ↗
4. Pérez-Herrero E, Fernández-Medarde A (2015) Advanced targeted therapies in cancer: drug nanocarriers, the future of chemotherapy. Eur J Pharm Biopharm 93:52–79. https://doi.org/10.1016/j.ejpb.2015.03.01810.1016/j.ejpb.2015.03.018 ↗
5. Mahapatra DK, Bharti SK, Asati V (2015) Anti-cancer chalcones: structural and molecular target perspectives. Eur J Med Chem 98:69–114. https://doi.org/10.1016/j.ejmech.2015.05.00410.1016/j.ejmech.2015.05.004 ↗
6. Mai CW, Yaeghoobi M, Abd-Rahman N, Kang YB, Pichika MR (2014) Chalcones with electron-withdrawing and electron-donating substituents: anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins. Eur J Med Chem 77:378–387. https://doi.org/10.1016/j.ejmech.2014.03.00210.1016/j.ejmech.2014.03.002 ↗
7. Syam S, Abdelwahab SI, Al-Mamary MA, Mohan S (2012) Synthesis of chalcones with anticancer activities. Molecules 17(6):6179–6195. https://doi.org/10.3390/molecules1706617910.3390/molecules17066179 ↗
8. Dong F, Jian C, Zhenghao F, Kai G, Zuliang L (2008) Synthesis of chalcones via Claisen-Schmidt condensation reaction catalyzed by acyclic acidic ionic liquids. Catal Commun 9(9):1924–1927. https://doi.org/10.1016/j.catcom.2008.03.02310.1016/j.catcom.2008.03.023 ↗
9. Singh P, Anand A, Kumar V (2014) Recent developments in biological activities of chalcones: a mini review. Eur J Med Chem 85:758–777. https://doi.org/10.1016/j.ejmech.2014.08.03310.1016/j.ejmech.2014.08.033 ↗
10. Dhaliwal JS, Moshawih S, Goh KW, Loy MJ, Hossain MS, Hermansyah A, Kotra V, Kifli N, Goh HP, Dhaliwal KS, Yassin H, Ming LC (2022) Pharmacotherapeutics applications and chemistry of chalcone derivatives. Molecules 27(20):7062. https://doi.org/10.3390/molecules2720706210.3390/molecules27207062 ↗
11. Danhier F, Feron O, Préat V (2010) To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release 148(2):135–146. https://doi.org/10.1016/j.jconrel.2010.08.02710.1016/j.jconrel.2010.08.027 ↗
12. Huda S, Alam MA, Sharma PK (2020) Smart nanocarriers-based drug delivery for cancer therapy: an innovative and developing strategy. J Drug Deliv Sci Technol 60:102018. https://doi.org/10.1016/j.jddst.2020.10201810.1016/j.jddst.2020.102018 ↗
13. Gupta J, Quadros M, Momin M (2023) Mesoporous silica nanoparticles: synthesis and multifaceted functionalization for controlled drug delivery. J Drug Deliv Sci Technol 81:104305. https://doi.org/10.1016/j.jddst.2023.10430510.1016/j.jddst.2023.104305 ↗
14. Ahmadi F, Sodagar-Taleghani A, Ebrahimnejad P, Moghaddam SPH, Ebrahimnejad F, Asare-Addo K, Nokhodchi A (2022) A review on the latest developments of mesoporous silica nanoparticles as a promising platform for diagnosis and treatment of cancer. Int J Pharm 122099. https://doi.org/10.1016/j.ijpharm.2022.12209910.1016/j.ijpharm.2022.122099 ↗
15. Zhou Y, Quan G, Wu Q, Zhang X, Niu B, Wu B, Huang Y, Pan X, Wu C (2018) Mesoporous silica nanoparticles for drug and gene delivery. Acta Pharm Sin B 8(2):165–177. https://doi.org/10.1016/j.apsb.2018.01.00710.1016/j.apsb.2018.01.007 ↗
16. Ngo D, Kalala M, Hogan V, Manchanayakage R (2014) One-pot synthesis of chalcone epoxides—a green chemistry strategy. Tetrahedron Lett 55(32):4496–4500. https://doi.org/10.1016/j.tetlet.2014.06.05710.1016/j.tetlet.2014.06.057 ↗
17. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1–2):55–63. https://doi.org/10.1016/0022-1759(83)90303-410.1016/0022-1759(83)90303-4 ↗
18. Badisa RB, Darling-Reed SF, Joseph P, Cooperwood JS, Latinwo LM, Goodman CB (2009) Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells. Anticancer Res 29(8):2993–2996
19. Shi M, Chen Z, Farnaghi S, Friis T, Mao X, Xiao Y, Wu C (2016) Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis. Acta Biomater 30:334–344. https://doi.org/10.1016/j.actbio.2015.11.03310.1016/j.actbio.2015.11.033 ↗
20. Andrade GF, Lima GDS, Gastelois PL, Assis GD, Macedo WADA, de Sousa EMB (2020) Surface modification and biological evaluation of kojic acid/silica nanoparticles as platforms for biomedical systems. Int J Appl Ceram Technol 17(1):380–391. https://doi.org/10.1111/ijac.1337610.1111/ijac.13376 ↗
21. Juvale K, Pape VF, Wiese M (2012) Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorg Med Chem 20(1):346–355. https://doi.org/10.1016/j.bmc.2011.10.07410.1016/j.bmc.2011.10.074 ↗
22. Wang L, Fan J, Tian B, Yang H, Yu C, Tu B, Zhao D (2004) Synthesis and characterization of small pore thick-walled SBA-16 templated by oligomeric surfactant with ultra-long hydrophilic chains. Microporous Mesoporous Mater 67(2–3):135–141. https://doi.org/10.1016/j.micromeso.2003.10.01510.1016/j.micromeso.2003.10.015 ↗
23. Duran A, Serna C, Fornes V, Navarro JF (1986) Structural considerations about SiO2 glasses prepared by sol-gel. J Non-Cryst Solids 82(1–3):69–77. https://doi.org/10.1016/0022-3093(86)90112-210.1016/0022-3093(86)90112-2 ↗
24. Shi B, Wang Y, Guo Y, Wang Y, Wang Y, Guo Y, Zhang Z, Liu X, Lu G (2009) Aminopropyl-functionalized silicas synthesized by W/O microemulsion for immobilization of penicillin G acylase. Catal Today 148(1–2):184–188. https://doi.org/10.1016/j.cattod.2009.02.01410.1016/j.cattod.2009.02.014 ↗
25. Sing KS (1989) The use of gas adsorption for the characterization of porous solids. Colloids Surf 38(1):113–124. https://doi.org/10.1016/0166-6622(89)80148-910.1016/0166-6622(89)80148-9 ↗
26. Freitas LBO, Corgosinho LM, Faria JAQA, dos Santos VM, Resende JM, Leal AS, Gomes DA, de Sousa EMB (2017) Multifunctional mesoporous silica nanoparticles for cancer-targeted, controlled drug delivery and imaging. Microporous Mesoporous Mater 242:271–283. https://doi.org/10.1016/j.micromeso.2017.01.03610.1016/j.micromeso.2017.01.036 ↗
27. Singh N, Kumar N, Rathee G, Sood D, Singh A, Tomar V, Dass SK, Chandra R (2020) Privileged scaffold chalcone: synthesis, characterization and its mechanistic interaction studies with BSA employing spectroscopic and chemoinformatics approaches. ACS Omega 5(5):2267–2279. https://doi.org/10.1021/acsomega.9b0347910.1021/acsomega.9b03479 ↗
28. Jia L, Shen J, Li Z, Zhang D, Zhang Q, Liu G, Zheng D, Tian X (2013) In vitro and in vivo evaluation of paclitaxel-loaded mesoporous silica nanoparticles with three pore sizes. Int J Pharm 445(1–2):12–19. https://doi.org/10.1016/j.ijpharm.2013.01.05810.1016/j.ijpharm.2013.01.058 ↗
29. Preta G (2020) New insights into targeting membrane lipids for cancer therapy. Front Cell Dev Biol 8:571237. https://doi.org/10.3389/fcell.2020.57123710.3389/fcell.2020.571237 ↗