Magnetic, biocompatible CoFe2O4/Fe3O4 core/shell nanoparticles: designing and improved hyperthermia properties
Source abstract
Abstract
In this study, the improved hyperthermia properties of a magnetic, biocompatible core/shell nanostructure containing 12 -nm hard magnetic CoFe2O4 nanoparticles as the core and soft magnetic Fe3O4 nanoparticles as the shell were reported. By simply using thermal decomposition synthesis method, CoFe2O4 nanoparticles were coated layer-by-layer by Fe3O4 nanoparticles to result the core/shell structure with a variable shell thickness. XRD analysis showed that the as-synthesized nanoparticles have face-centered cubic structure with ferrite spinel single phase. TEM images showed that particle size of the core–shell structure increased by 0.7 − 2.1 nm and monotonously with the Fe3O4 coating. The coercivity (Hc) of the core/shell nanoparticles decreased remarkably compared to that of CoFe2O4 core nanoparticles while saturation magnetization Ms significantly increased, indicating the successful formation of the soft magnetic Fe3O4 shell layer. Dynamic light scattering (DLS) analysis revealed that the uniform size and good stability of the magnetic fluids based on the as-synthesized CoFe2O4/Fe3O4 core/shell nanoparticles using poly(maleic anhydride-alt-1-octadecene) (PMAO) as the phase transfer ligand were achieved. Comparing to the core CoFe2O4 nanoparticle, the specific absorption rate (SAR) values of the core/shell nanoparticles were significantly higher and, especially, were more than doubled with shell thickness of 2 nm. Additionally, the cytotoxicity test indicated low toxicity of the magnetic fluid on HEK-293 normal cells. These results showed that the studied CoFe2O4/Fe3O4 core/shell nanoparticles with their high biocompatibility and improved hyperthermia properties are expected to be usable in biomedicine, especially in hyperthermia cancer treatment. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Magnetic Properties and Synthesis of Ferrites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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