Review on iron nanoparticles for cancer theranostics: synthesis, modification, characterization and applications
Source abstract
Abstract
Cancer is one of the leading causes of death worldwide. Although standard strategies such as chemotherapy and radiotherapy have shown to be successful for cancer treatment, their effectiveness can be limited. Due to their physicochemical properties, nanoparticles can be used to overcome the drawbacks apparent from conventional cancer treatments, with a wide variety of specialized treatment options and active targeting strategies available for treating tumors. This review focuses on iron nanoparticles as promising cancer therapy and imaging nano-agents and on the main synthesis and modification techniques available for constructing these nanoparticles for cancer. A discussion on different types of iron nanoparticles for cancer theranostics is provided to demonstrate the variety of imaging modalities and therapies available.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · Nanoparticles: synthesis and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Khan I, Saeed K, Khan I (2019) Nanoparticles: properties, applications and toxicities. Arab J Chem 12(7):908–93110.1016/j.arabjc.2017.05.011 ↗
2. Patil SS, Shedbalkar UU, Truskewycz A, Chopade BA, Ball AS (2016) Nanoparticles for environmental clean-up: a review of potential risks and emerging solutions. Environ Technol Innov 5:10–2110.1016/j.eti.2015.11.001 ↗
3. Singh RP, Handa R, Manchanda G (2021) Nanoparticles in sustainable agriculture: an emerging opportunity. J Control Release 329:1234–124810.1016/j.jconrel.2020.10.051 ↗
4. Alsaba MT, Al Dushaishi MF, Abbas AK (2020) A comprehensive review of nanoparticles applications in the oil and gas industry. J Pet Explor Prod Technol 10:1389–139910.1007/s13202-019-00825-z ↗
5. Nikzamir M, Akbarzadeh A, Panahi Y (2021) An overview on nanoparticles used in biomedicine and their cytotoxicity. J Drug Deliv Sci Technol 61:10231610.1016/j.jddst.2020.102316 ↗
6. Shahcheraghi N, Golchin H, Sadri Z, Tabari Y, Borhanifar F, Makani S (2022) Nano-biotechnology, an applicable approach for sustainable future. 3 Biotech 12(3):6510.1007/s13205-021-03108-9 ↗
7. Chen H, Zhang W, Zhu G, Xie J, Chen X (2017) Rethinking cancer nanotheranostics. Nat Rev Mater 2(7):1–1810.1038/natrevmats.2017.24 ↗
8. Madamsetty VS, Mukherjee A, Mukherjee S (2019) Recent trends of the bio-inspired nanoparticles in cancer theranostics. Front Pharmacol 10:126410.3389/fphar.2019.01264 ↗
9. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R (2021) Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov 20(2):101–12410.1038/s41573-020-0090-8 ↗
10. Heneweer C, Holland JP, Divilov V, Carlin S, Lewis JS (2011) Magnitude of enhanced permeability and retention effect in tumors with different phenotypes: 89Zr-albumin as a model system. J Nucl Med 52(4):625–63310.2967/jnumed.110.083998 ↗
11. Maldonado-Camargo L, Unni M, Rinaldi C (2017) Magnetic characterization of iron oxide nanoparticles for biomedical applications. Methods and Protocols, Biomedical Nanotechnology, pp 47–71
12. Carvell J, Ayieta E, Gavrin A, Cheng R, Shah V, Sokol P (2010) Magnetic properties of iron nanoparticle. J Appl Phys 107(10):10391310.1063/1.3428415 ↗
13. Kaur K, Sidhu AK (2021) Green synthesis: an eco-friendly route for the synthesis of iron oxide nanoparticles. Front Nanotechnol 3:65506210.3389/fnano.2021.655062 ↗
14. Wei H, Hu Y, Wang J, Gao X, Qian X, Tang M (2021) Superparamagnetic iron oxide nanoparticles: cytotoxicity, metabolism, and cellular behavior in biomedicine applications. Int J Nanomedicine 16:609710.2147/IJN.S321984 ↗
15. Nosrati H, Salehiabar M, Fridoni M, Abdollahifar M-A, Kheiri Manjili H, Davaran S et al (2019) New insight about biocompatibility and biodegradability of iron oxide magnetic nanoparticles: stereological and in vivo MRI monitor. Sci Rep 9(1):1–1010.1038/s41598-019-43650-4 ↗
16. Portilla Y, Fernández-Afonso Y, Pérez-Yagüe S, Mulens-Arias V, Morales M, Gutiérrez L et al (2022) Different coatings on magnetic nanoparticles dictate their degradation kinetics in vivo for 15 months after intravenous administration in mice. J Nanobiotechnology 20(1):1–2310.1186/s12951-022-01747-5 ↗
17. Bourquin J, Milosevic A, Hauser D, Lehner R, Blank F, Petri-Fink A et al (2018) Biodistribution, clearance, and long-term fate of clinically relevant nanomaterials. Adv Mater 30(19):170430710.1002/adma.201704307 ↗
18. Li YF, Chen C (2011) Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small. 7(21):2965–298010.1002/smll.201101059 ↗
19. Besenhard MO, LaGrow AP, Hodzic A, Kriechbaum M, Panariello L, Bais G et al (2020) Co-precipitation synthesis of stable iron oxide nanoparticles with NaOH: new insights and continuous production via flow chemistry. Chem Eng J 399:12574010.1016/j.cej.2020.125740 ↗
20. LaGrow AP, Besenhard MO, Hodzic A, Sergides A, Bogart LK, Gavriilidis A et al (2019) Unravelling the growth mechanism of the co-precipitation of iron oxide nanoparticles with the aid of synchrotron X-ray diffraction in solution. Nanoscale. 11(14):6620–662810.1039/C9NR00531E ↗
21. Roth H-C, Schwaminger SP, Schindler M, Wagner FE, Berensmeier S (2015) Influencing factors in the CO-precipitation process of superparamagnetic iron oxide nano particles: a model based study. J Magn Magn Mater 377:81–8910.1016/j.jmmm.2014.10.074 ↗
22. Hui BH, Salimi MN (2020) Production of iron oxide nanoparticles by co-precipitation method with optimization studies of processing temperature, pH and stirring rate. In: IOP conference series: materials science and engineering. IOP Publishing, p 012036
23. Pereira C, Pereira AM, Rocha M, Freire C, Geraldes CF (2015) Architectured design of superparamagnetic Fe 3 O 4 nanoparticles for application as MRI contrast agents: mastering size and magnetism for enhanced relaxivity. J Mater Chem B 3(30):6261–627310.1039/C5TB00789E ↗
24. Pereira C, Pereira AM, Fernandes C, Rocha M, Mendes R, Fernández-García MP et al (2012) Superparamagnetic MFe2O4 (M= Fe, Co, Mn) nanoparticles: tuning the particle size and magnetic properties through a novel one-step coprecipitation route. Chem Mater 24(8):1496–150410.1021/cm300301c ↗
25. Lokhat D, Brijlal S, Naidoo DE, Cm P, Kadwa E (2022) Synthesis of size-and-shape-controlled Iron oxide nanoparticles via Coprecipitation and in situ magnetic separation. Ind Eng Chem Res 61(46):16980–1699110.1021/acs.iecr.2c02350 ↗
26. Liu Y, Jia S, Wu Q, Ran J, Zhang W, Wu S (2011) Studies of Fe3O4-chitosan nanoparticles prepared by co-precipitation under the magnetic field for lipase immobilization. Catal Commun 12(8):717–72010.1016/j.catcom.2010.12.032 ↗
27. Wu S, Sun A, Zhai F, Wang J, Xu W, Zhang Q et al (2011) Fe3O4 magnetic nanoparticles synthesis from tailings by ultrasonic chemical co-precipitation. Mater Lett 65(12):1882–188410.1016/j.matlet.2011.03.065 ↗
28. Gahrouei ZE, Imani M, Soltani M, Shafyei A (2020) Synthesis of iron oxide nanoparticles for hyperthermia application: effect of ultrasonic irradiation assisted co-precipitation route. Adv Nat Sci Nanosci Nanotechnol 11(2):02500110.1088/2043-6254/ab878f ↗
29. Al-Harbi L, Darwish MS (2022) Functionalized iron oxide nanoparticles: synthesis through ultrasonic-assisted co-precipitation and performance as hyperthermic agents for biomedical applications. Heliyon. 8(6):e0965410.1016/j.heliyon.2022.e09654 ↗
30. Suh SK, Yuet K, Hwang DK, Bong KW, Doyle PS, Hatton TA (2012) Synthesis of nonspherical superparamagnetic particles: in situ coprecipitation of magnetic nanoparticles in microgels prepared by stop-flow lithography. J Am Chem Soc 134(17):7337–734310.1021/ja209245v ↗
31. Oberdick SD, Russek SE, Poorman ME, Zabow G (2020) Observation of iron oxide nanoparticle synthesis in magnetogels using magnetic resonance imaging. Soft Matter 16(45):10244–1025110.1039/D0SM01566K ↗
32. Glasgow W, Fellows B, Qi B, Darroudi T, Kitchens C, Ye L et al (2016) Continuous synthesis of iron oxide (Fe3O4) nanoparticles via thermal decomposition. Particuology. 26:47–5310.1016/j.partic.2015.09.011 ↗
33. Cotin G, Kiefer C, Perton F, Boero M, Ozdamar B, Bouzid A et al (2018) Evaluating the critical roles of precursor nature and water content when tailoring magnetic nanoparticles for specific applications. ACS Appl Nano Mater 1(8):4306–431610.1021/acsanm.8b01123 ↗
34. Teng X, Yang H (2004) Effects of surfactants and synthetic conditions on the sizes and self-assembly of monodisperse iron oxide nanoparticles. J Mater Chem 14(4):774–77910.1039/b311610g ↗
35. Wetterskog E, Agthe M, Mayence A, Grins J, Wang D, Rana S et al (2014) Precise control over shape and size of iron oxide nanocrystals suitable for assembly into ordered particle arrays. Sci Technol Adv Mater 15(5):05501010.1088/1468-6996/15/5/055010 ↗
36. Patil RM, Thorat ND, Shete PB, Bedge PA, Gavde S, Joshi MG et al (2018) Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles. Biochem Biophys Rep 13:63–72
37. Injumpa W, Ritprajak P, Insin N (2017) Size-dependent cytotoxicity and inflammatory responses of PEGylated silica-iron oxide nanocomposite size series. J Magn Magn Mater 427:60–6610.1016/j.jmmm.2016.11.015 ↗
38. Peng S, Wang C, Xie J, Sun S (2006) Synthesis and stabilization of monodisperse Fe nanoparticles. J Am Chem Soc 128(33):10676–1067710.1021/ja063969h ↗
39. Ahmadpoor F, Masood A, Feliu N, Parak WJ, Shojaosadati SA (2021) The effect of surface coating of iron oxide nanoparticles on magnetic resonance imaging relaxivity. Front Nanotechnol 3:64473410.3389/fnano.2021.644734 ↗
40. Belaïd S, Stanicki D, Vander Elst L, Muller RN, Laurent S (2018) Influence of experimental parameters on iron oxide nanoparticle properties synthesized by thermal decomposition: size and nuclear magnetic resonance studies. Nanotechnology. 29(16):16560310.1088/1361-6528/aaae59 ↗
41. Ge S, Shi X, Sun K, Li C, Uher C, Baker JR Jr et al (2009) Facile hydrothermal synthesis of iron oxide nanoparticles with tunable magnetic properties. J Phys Chem C 113(31):13593–1359910.1021/jp902953t ↗
42. Ozel F, Kockar H, Karaagac O (2015) Growth of iron oxide nanoparticles by hydrothermal process: effect of reaction parameters on the nanoparticle size. J Supercond Nov Magn 28:823–82910.1007/s10948-014-2707-9 ↗
43. Xu C, Teja AS (2008) Continuous hydrothermal synthesis of iron oxide and PVA-protected iron oxide nanoparticles. J Supercrit Fluids 44(1):85–9110.1016/j.supflu.2007.09.033 ↗
44. Colombo C, Palumbo G, Di Iorio E, Song X, Jiang Z, Liu Q et al (2015) Influence of hydrothermal synthesis conditions on size, morphology and colloidal properties of hematite nanoparticles. Nano-Struct Nano-Objects 2:19–2710.1016/j.nanoso.2015.07.004 ↗
45. Torres-Gómez N, Nava O, Argueta-Figueroa L, García-Contreras R, Baeza-Barrera A, Vilchis-Nestor AR (2019) Shape tuning of magnetite nanoparticles obtained by hydrothermal synthesis: effect of temperature. J Nanomater 201910.1155/2019/7921273 ↗
46. Hachani R, Lowdell M, Birchall M, Hervault A, Mertz D, Begin-Colin S et al (2016) Polyol synthesis, functionalisation, and biocompatibility studies of superparamagnetic iron oxide nanoparticles as potential MRI contrast agents. Nanoscale. 8(6):3278–328710.1039/C5NR03867G ↗
47. Rao BG, Mukherjee D, Reddy BM (2017) Novel approaches for preparation of nanoparticles. In: Nanostructures for novel therapy. Elsevier, pp 1–36
48. Joseyphus RJ, Shinoda K, Kodama D, Jeyadevan B (2010) Size controlled Fe nanoparticles through polyol process and their magnetic properties. Mater Chem Phys 123(2–3):487–49310.1016/j.matchemphys.2010.05.001 ↗
49. Karimzadeh I, Dizaji HR, Aghazadeh M (2016) Development of a facile and effective electrochemical strategy for preparation of iron oxides (Fe3O4 and γ-Fe2O3) nanoparticles from aqueous and ethanol mediums and in situ PVC coating of Fe3O4 superparamagnetic nanoparticles for biomedical applications. J Magn Magn Mater 416:81–8810.1016/j.jmmm.2016.05.015 ↗
50. Yousefi T, Davarkhah R, Golikand AN, Mashhadizadeh MH, Abhari A (2013) Facile cathodic electrosynthesis and characterization of iron oxide nano-particles. Progress in Natural Science: Materials International 23(1):51–5410.1016/j.pnsc.2013.01.007 ↗
51. Cabrera L, Gutierrez S, Menendez N, Morales M, Herrasti P (2008) Magnetite nanoparticles: electrochemical synthesis and characterization. Electrochim Acta 53(8):3436–344110.1016/j.electacta.2007.12.006 ↗
52. Pascal C, Pascal J, Favier F, Elidrissi Moubtassim M, Payen C (1999) Electrochemical synthesis for the control of γ-Fe2O3 nanoparticle size. Morphology, microstructure, and magnetic behavior. Chem Mater 11(1):141–14710.1021/cm980742f ↗
53. Ramimoghadam D, Bagheri S, Abd Hamid SB (2014) Progress in electrochemical synthesis of magnetic iron oxide nanoparticles. J Magn Magn Mater 368:207–22910.1016/j.jmmm.2014.05.015 ↗
54. Rivera-Chaverra MJ, Restrepo-Parra E, Acosta-Medina CD, Mello A, Ospina R (2020) Synthesis of oxide iron nanoparticles using laser ablation for possible hyperthermia applications. Nanomaterials. 10(11):209910.3390/nano10112099 ↗
55. Dadashi S, Poursalehi R, Delavari H (2015) Structural and optical properties of pure iron and iron oxide nanoparticles prepared via pulsed Nd: YAG laser ablation in liquid. Procedia Mater Sci 11:722–72610.1016/j.mspro.2015.11.052 ↗
56. Balachandran A, Sreenilayam SP, Madanan K, Thomas S, Brabazon D (2022) Nanoparticle production via laser ablation synthesis in solution method and printed electronic application-a brief review. Results. Engineering.:10064610.1016/j.rineng.2022.100646 ↗
57. Kumari A, Singla R, Guliani A, Yadav SK (2014) Nanoencapsulation for drug delivery. EXCLI J 13:265
58. Mukh-Qasem RA, Gedanken A (2005) Sonochemical synthesis of stable hydrosol of Fe3O4 nanoparticles. J Colloid Interface Sci 284(2):489–49410.1016/j.jcis.2004.10.073 ↗
59. Ali Dheyab M, Aziz AA, Jameel MS (2021) Recent advances in inorganic nanomaterials synthesis using sonochemistry: a comprehensive review on iron oxide, gold and iron oxide coated gold nanoparticles. Molecules. 26(9):245310.3390/molecules26092453 ↗
60. Lopez Perez J, Lopez Quintela M, Mira J, Rivas J, Charles S (1997) Advances in the preparation of magnetic nanoparticles by the microemulsion method. J Phys Chem B 101(41):8045–804710.1021/jp972046t ↗
61. Wongwailikhit K, Horwongsakul S (2011) The preparation of iron (III) oxide nanoparticles using W/O microemulsion. Mater Lett 65(17–18):2820–282210.1016/j.matlet.2011.05.063 ↗
62. Salvador M, Gutiérrez G, Noriega S, Moyano A, Blanco-López MC, Matos M (2021) Microemulsion synthesis of superparamagnetic nanoparticles for bioapplications. Int J Mol Sci 22(1):42710.3390/ijms22010427 ↗
63. Lu T, Wang J, Yin J, Wang A, Wang X, Zhang T (2013) Surfactant effects on the microstructures of Fe3O4 nanoparticles synthesized by microemulsion method. Colloids Surf A Physicochem Eng Asp 436:675–68310.1016/j.colsurfa.2013.08.004 ↗
64. Richard B, Lemyre J-L, Ritcey AM (2017) Nanoparticle size control in microemulsion synthesis. Langmuir. 33(19):4748–475710.1021/acs.langmuir.7b00773 ↗
65. Predoi D, Crisan O, Jitianu A, Valsangiacom M, Raileanu M, Crisan M et al (2007) Iron oxide in a silica matrix prepared by the sol–gel method. Thin Solid Films 515(16):6319–632310.1016/j.tsf.2006.11.148 ↗
66. Sharafi Z, Bakhshi B, Javidi J, Adrangi S (2018) Synthesis of silica-coated iron oxide nanoparticles: preventing aggregation without using additives or seed pretreatment. Iranian Journal of Pharmaceutical Research: IJPR 17(1):386
67. Raja K, Jaculine MM, Jose M, Verma S, Prince A, Ilangovan K et al (2015) Sol–gel synthesis and characterization of α-Fe2O3 nanoparticles. Superlattice Microst 86:306–31210.1016/j.spmi.2015.07.044 ↗
68. Mathevula L, Noto L, Mothudi BM, Chithambo M, Dhlamini M (2017) Structural and optical properties of sol-gel derived α-Fe2O3 nanoparticles. J Lumin 192:879–88710.1016/j.jlumin.2017.07.055 ↗
69. Danks AE, Hall SR, Schnepp Z (2016) The evolution of ‘sol–gel’chemistry as a technique for materials synthesis. Mater Horiz 3(2):91–11210.1039/C5MH00260E ↗
70. Sharma D, Kanchi S, Bisetty K (2019) Biogenic synthesis of nanoparticles: a review. Arab J Chem 12(8):3576–360010.1016/j.arabjc.2015.11.002 ↗
71. Jacinto M, Silva V, Valladão D, Souto R (2021) Biosynthesis of magnetic iron oxide nanoparticles: a review. Biotechnol Lett 43:1–1210.1007/s10529-020-03047-0 ↗
72. da Silva Alves DC, Healy B, Pinto LAA, Cadaval TRSA Jr, Breslin CB (2021) Recent developments in chitosan-based adsorbents for the removal of pollutants from aqueous environments. Molecules. 26(3):59410.3390/molecules26030594 ↗
73. Khurshid H, Nemati Z, Iglesias Ó, Alonso J, Phan M-H, Srikanth H (2021) Hollow magnetic nanoparticles. New Trends in Nanoparticle Magnetism:137–15810.1007/978-3-030-60473-8_6 ↗
74. Kumar P, Khanduri H, Pathak S, Singh A, Basheed G, Pant R (2020) Temperature selectivity for single phase hydrothermal synthesis of PEG-400 coated magnetite nanoparticles. Dalton Trans 49(25):8672–868310.1039/D0DT01318H ↗
75. Meng Q, Wang Z, Chai X, Weng Z, Ding R, Dong L (2016) Fabrication of hematite (α-Fe2O3) nanoparticles using electrochemical deposition. Appl Surf Sci 368:303–30810.1016/j.apsusc.2016.02.007 ↗
76. Amendola V, Riello P, Meneghetti M (2011) Magnetic nanoparticles of iron carbide, iron oxide, iron@ iron oxide, and metal iron synthesized by laser ablation in organic solvents. J Phys Chem C 115(12):5140–514610.1021/jp109371m ↗
77. Zhang S, Zhang Y, Wang Y, Liu S, Deng Y (2012) Sonochemical formation of iron oxide nanoparticles in ionic liquids for magnetic liquid marble. Phys Chem Chem Phys 14(15):5132–513810.1039/c2cp23675c ↗
78. Eriksson S, Nylén U, Rojas S, Boutonnet M (2004) Preparation of catalysts from microemulsions and their applications in heterogeneous catalysis. Appl Catal A Gen 265(2):207–21910.1016/j.apcata.2004.01.014 ↗
79. Horst MF, Lassalle V, Ferreira ML (2015) Nanosized magnetite in low cost materials for remediation of water polluted with toxic metals, azo-and antraquinonic dyes. Front Environ Sci Eng 9:746–76910.1007/s11783-015-0814-x ↗
80. Madivoli ES, Kareru PG, Maina EG, Nyabola AO, Wanakai SI, Nyang’au JO. (2019) Biosynthesis of iron nanoparticles using Ageratum conyzoides extracts, their antimicrobial and photocatalytic activity. SN. Appl Sci 1:1–11
81. Yoon J, Cho SH, Seong H (2017) Multifunctional ultrasmall superparamagnetic iron oxide nanoparticles as a theranostic agent. Colloids Surf A Physicochem Eng Asp 520:892–90210.1016/j.colsurfa.2017.02.080 ↗
82. Gao Q, Xie W, Wang Y, Wang D, Guo Z, Gao F et al (2018) A theranostic nanocomposite system based on radial mesoporous silica hybridized with Fe 3 O 4 nanoparticles for targeted magnetic field responsive chemotherapy of breast cancer. RSC Adv 8(8):4321–432810.1039/C7RA12446E ↗
83. Karimzadeh I, Aghazadeh M, Ganjali MR, Norouzi P, Doroudi T, Kolivand PH (2017) Saccharide-coated superparamagnetic Fe3O4 nanoparticles (SPIONs) for biomedical applications: an efficient and scalable route for preparation and in situ surface coating through cathodic electrochemical deposition (CED). Mater Lett 189:290–29410.1016/j.matlet.2016.12.010 ↗
84. Griaznova OY, Belyaev IB, Sogomonyan AS, Zelepukin IV, Tikhonowski GV, Popov AA et al (2022) Laser synthesized Core-satellite Fe-au nanoparticles for multimodal in vivo imaging and in vitro Photothermal therapy. Pharmaceutics. 14(5):99410.3390/pharmaceutics14050994 ↗
85. Dolores R, Raquel S, Adianez G-L (2015) Sonochemical synthesis of iron oxide nanoparticles loaded with folate and cisplatin: effect of ultrasonic frequency. Ultrason Sonochem 23:391–39810.1016/j.ultsonch.2014.08.005 ↗
86. Zhao J, Li X, Wang X, Wang X (2019) Fabrication of hybrid nanostructures based on Fe3O4 nanoclusters as Theranostic agents for magnetic resonance imaging and drug delivery. Nanoscale Res Lett 14(1):200. https://doi.org/10.1186/s11671-019-3026-710.1186/s11671-019-3026-7 ↗
87. Sulaiman GM, Tawfeeq AT, Naji AS (2018) Biosynthesis, characterization of magnetic iron oxide nanoparticles and evaluations of the cytotoxicity and DNA damage of human breast carcinoma cell lines. Artif Cells Nanomed Biotechnol 46(6):1215–122910.1080/21691401.2017.1366335 ↗
88. Smith BR, Gambhir SS (2017) Nanomaterials for in vivo imaging. Chem Rev 117(3):901–98610.1021/acs.chemrev.6b00073 ↗
89. Kumar R, Mondal K, Panda PK, Kaushik A, Abolhassani R, Ahuja R et al (2020) Core–shell nanostructures: perspectives towards drug delivery applications. J Mater Chem B 8(39):8992–902710.1039/D0TB01559H ↗
90. Oka C, Ushimaru K, Horiishi N, Tsuge T, Kitamoto Y (2015) Core–shell composite particles composed of biodegradable polymer particles and magnetic iron oxide nanoparticles for targeted drug delivery. J Magn Magn Mater 381:278–28410.1016/j.jmmm.2015.01.005 ↗
91. Pimpha N, Chaleawlert-umpon S, Sunintaboon P (2012) Core/shell polymethyl methacrylate/polyethyleneimine particles incorporating large amounts of iron oxide nanoparticles prepared by emulsifier-free emulsion polymerization. Polymer. 53(10):2015–202210.1016/j.polymer.2012.03.019 ↗
92. Awada H, Al Samad A, Laurencin D, Gilbert R, Dumail X, El Jundi A et al (2019) Controlled anchoring of iron oxide nanoparticles on polymeric nanofibers: easy access to Core@ Shell organic–inorganic nanocomposites for magneto-scaffolds. ACS Appl Mater Interfaces 11(9):9519–952910.1021/acsami.8b19099 ↗
93. Zhou Z, Sun Y, Shen J, Wei J, Yu C, Kong B et al (2014) Iron/iron oxide core/shell nanoparticles for magnetic targeting MRI and near-infrared photothermal therapy. Biomaterials. 35(26):7470–747810.1016/j.biomaterials.2014.04.063 ↗
94. Herman DA, Ferguson P, Cheong S, Hermans IF, Ruck BJ, Allan KM et al (2011) Hot-injection synthesis of iron/iron oxide core/shell nanoparticles for T 2 contrast enhancement in magnetic resonance imaging. Chem Commun 47(32):9221–922310.1039/c1cc13416g ↗
95. Behrens S (2011) Preparation of functional magnetic nanocomposites and hybrid materials: recent progress and future directions. Nanoscale. 3(3):877–89210.1039/C0NR00634C ↗
96. Tadić M, Kusigerski V, Marković D, Panjan M, Milošević I, Spasojević V (2012) Highly crystalline superparamagnetic iron oxide nanoparticles (SPION) in a silica matrix. J Alloys Compd 525:28–3310.1016/j.jallcom.2012.02.056 ↗
97. Barbaro D, Di Bari L, Gandin V, Marzano C, Ciaramella A, Malventi M et al (2022) Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapor synthesis can target GLUT1 overexpressing tumors: in vitro tests and in vivo preliminary assessment. PLoS One 17(6):e026960310.1371/journal.pone.0269603 ↗
98. Materia ME, Guardia P, Sathya A, Pernia Leal M, Marotta R, Di Corato R et al (2015) Mesoscale assemblies of iron oxide nanocubes as heat mediators and image contrast agents. Langmuir. 31(2):808–81610.1021/la503930s ↗
99. Sathya A, Kalyani S, Ranoo S, Philip J (2017) One-step microwave-assisted synthesis of water-dispersible Fe3O4 magnetic nanoclusters for hyperthermia applications. J Magn Magn Mater 439:107–11310.1016/j.jmmm.2017.05.018 ↗
100. Redl FX, Cho K-S, Murray CB, O'Brien S (2003) Three-dimensional binary superlattices of magnetic nanocrystals and semiconductor quantum dots. Nature. 423(6943):968–97110.1038/nature01702 ↗