Fabrication of PEGylated liposome in microfluidic flow process using supercritical CO2
Source abstract
Abstract
Liposomes have attracted attention as appealing drug carriers in the pharmaceutical industry, which has promoted the research about the fabrication method of liposomes. In this study, microfluidic flow process using supercritical carbon dioxide (scCO2) was applied to the fabrication of PEGylated liposomes. We investigated the effect of PEG-lipid concentration on the liposome properties such as size distribution, encapsulation efficiency, and fixed aqueous layer thickness, while the supplying line of PEG-lipid was varied. As a result, microfluidic process using scCO2 gave the PEGylated liposome with narrower size distribution and higher encapsulation efficiency than those from the thin layer method. In addition, a fixed aqueous layer thickness could be successfully controlled by changing the PEG-lipid concentration. These results suggest that microfluidic process using scCO2 can be a promising technique to fabricate the PEGylated liposome with controllable size and PEGylation state. Graphical Abstract
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Phase Equilibria and Thermodynamics · Innovative Microfluidic and Catalytic Techniques Innovation · Microfluidic and Capillary Electrophoresis Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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