Differential Pulse Voltammetric Determination of Sildenafil Using Nano-Iron Oxides Modified Electrode
Source abstract
Abstract
Ferromagnetic nanoparticles (FeNPs) have been successfully prepared by using solvothermal reduction method with polyethylene glycol as a solvent. The obtained materials were characterized by X-ray diffraction, scanning electron microscopy, Raman spectroscopy, nitrogen adsorption/desorption isotherms, and vibrating sample magnetometer. The magnetic properties and morphology of iron oxides was found to depend on the solvothermal temperatures. An increase in heating temperature from 120 to 240 °C did not only enhance the saturation magnetization from 21 to 81 emu g−1 but also produced larger, highly crystalline cubic particles of FeNPs. The development of FeNPs-modified glassy carbon electrode (GCE) using Nafion as a binder for sildenafil (SIL) detection was studied. Cyclic voltammetry and differential pulse voltammetry methods were employed for the electrochemical analysis of SIL using the modified electrode. The proposed sensor exhibited excellent electrocatalytic activity towards SIL oxidation with an enhancement in oxidation peak current. Under the optimum conditions, the current response for the determination of SIL was linear in two concentration ranges of 1.33–9.20 and 9.20–80.76 ppm and the limit of detection was 1.01 ppm. This sensor was then used for the determination of SIL in real samples with satisfactory results.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Pharmacological Effects and Assays · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (41)
Show source-provided references
1. Barnett CF, Machado RF (2006) Sildenafil in the treatment of pulmonary hypertension. Vascular health and risk management 2:41110.2147/vhrm.2006.2.4.411 ↗
2. Othman A, Rizk N, El-Shahawi M (2004) Polymer membrane sensors for sildenafil citrate (Viagra) determination in pharmaceutical preparations. Anal Chim Acta 515:303–30910.1016/j.aca.2004.01.016 ↗
3. Smith KM, Romanelli F (2005) Recreational use and misuse of phosphodiesterase 5 inhibitors. J Am Pharm Assoc 45:63–7510.1331/1544345052843165 ↗
4. U. Viagra, Physician Prescribing Information and US Patient Product Information for Health Care Professionals (PDF), ed: September, 2015.
5. Tunctan B, Korkmaz B, Yildirim H, Tamer L, Atik U, Buharalioglu C (2005) Increased production of nitric oxide contributes to renal oxidative stress in endotoxemic rat. Am J Infect Dis 1:111–11510.3844/ajidsp.2005.111.115 ↗
6. Karaarslan C (2020) Ocular side effects of sildenafil that persist beyond 24 h—a case series. Front Neurol 11:6710.3389/fneur.2020.00067 ↗
7. Mokhtar S, Chin S-T, Kee C-L, Low M-Y, Drummer O, Marriott P (2016) Rapid determination of sildenafil and its analogues in dietary supplements using gas chromatography–triple quadrupole mass spectrometry. J Pharm Biomed Anal 121:188–19610.1016/j.jpba.2016.01.034 ↗
8. Weinmann W, Bohnert M, Wiedemann A, Renz M, Lehmann N, Pollak S (2001) Post-mortem detection and identification of sildenafil (Viagra) and its metabolites by LC/MS and LC/MS/MS. Int J Legal Med 114:252–25810.1007/s004140000178 ↗
9. E. Öztürk Er, B. Özbek, and S. Bakırdere, Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions, Journal of separation science, vol. 42, pp. 475–483, 2019.10.1002/jssc.201800734 ↗
10. Wang CC, Gomez RA, Fernandez LP (2013) Determination of sildenafil by preconcentration on surfactant coated polymeric resin followed by spectrofluorimetry. J pharma anal 3:173–17910.1016/j.jpha.2012.11.001 ↗
11. Amin AS, Moustafa ME, El-Dosoky RM (2009) Colorimetric determination of sildenafil citrate (Viagra) through ion-associate complex formation. J AOAC Int 92:125–13010.1093/jaoac/92.1.125 ↗
12. Jiang H, Zhan H-L, Wu X-F (2004) Spectrophotometric method for the determination of sildenafil with methylene blue. J ANALYTICAL SCI 20:287–28910.2116/analsci.20.1055 ↗
13. Raril C, Manjunatha J (2020) A simple approach for the electrochemical determination of vanillin at ionic surfactant modified graphene paste electrode. Microchem J 154:10457510.1016/j.microc.2019.104575 ↗
14. Chen S, Wang C, Zhang M, Zhang W, Qi J, Sun X et al (2020) N-doped Cu-MOFs for efficient electrochemical determination of dopamine and sulfanilamide. J Hazard Mater 390:12215710.1016/j.jhazmat.2020.122157 ↗
15. Fekry A, Shehata M, Azab S, Walcarius A (2020) Voltammetric detection of caffeine in pharmacological and beverages samples based on simple nano-Co (II, III) oxide modified carbon paste electrode in aqueous and micellar media. Sens Actuators, B Chem 302:12717210.1016/j.snb.2019.127172 ↗
16. Rouhani M, Soleymanpour A (2020) Molecularly imprinted sol-gel electrochemical sensor for sildenafil based on a pencil graphite electrode modified by Preyssler heteropolyacid/gold nanoparticles/MWCNT nanocomposite. Microchim Acta 187:1–1610.1007/s00604-020-04482-6 ↗
17. Lović J, Trišović N, Antanasijević J, Nikolić ND, Stevanović S, Mijin D et al (2016) Electrochemical determination of sildenafil citrate as standard, in tablets and spiked with human serum at gold and cystein modified gold electrode. J Electroanal Chem 782:103–10710.1016/j.jelechem.2016.10.022 ↗
18. Batista EF, Sartori ER, Medeiros RA, Rocha-Filho RC, Fatibello-Filho O (2010) Differential pulse voltammetric determination of sildenafil citrate (Viagra®) in pharmaceutical formulations using a boron-doped diamond electrode. Anal Lett 43:1046–105410.1080/00032710903491153 ↗
19. Gopalan AI, Lee KP, Komathi S (2011) Strategically functionalized carbon nanotubes as the ultrasensitive electrochemical probe for picomolar detection of sildenafil citrate (Viagra). Biosens Bioelectron 26:3018–302210.1016/j.bios.2010.12.005 ↗
20. Hu S, Yu Y, Guan Y, Li Y, Wang B, Zhu M (2020) Two-dimensional TiO2 (001) nanosheets as an effective photo-assisted recyclable sensor for the electrochemical detection of bisphenol A. Chin Chem Lett 31:2839–284210.1016/j.cclet.2020.08.021 ↗
21. Sharma A, Arya S, Chauhan D, Solanki PR, Khajuria S, Khosla A (2020) Synthesis of Au–SnO2 nanoparticles for electrochemical determination of vitamin B12. J Market Res 9:14321–14337
22. Goyal RN, Singh SP (2006) Voltammetric determination of paracetamol at C60-modified glassy carbon electrode. Electrochim Acta 51:3008–301210.1016/j.electacta.2005.08.036 ↗
23. Cao X, Wang N (2011) A novel non-enzymatic glucose sensor modified with Fe2O3 nanowire arrays. Analyst 136:4241–424610.1039/c1an15367f ↗
24. Suresh R, Prabu R, Vijayaraj A, Giribabu K, Stephen A, Narayanan V (2012) Fabrication of α-Fe2O3 nanoparticles for the electrochemical detection of uric acid. Synth React Inorg, Met-Org, Nano-Met Chem 42:303–30710.1080/15533174.2011.610022 ↗
25. Gong J, Lin X (2003) Facilitated electron transfer of hemoglobin embedded in nanosized Fe3O4 matrix based on paraffin impregnated graphite electrode and electrochemical catalysis for trichloroacetic acid. Microchem J 75:51–5710.1016/S0026-265X(03)00053-5 ↗
26. Teymourian H, Salimi A, Khezrian S (2013) Fe3O4 magnetic nanoparticles/reduced graphene oxide nanosheets as a novel electrochemical and bioeletrochemical sensing platform. Biosens Bioelectron 49:1–810.1016/j.bios.2013.04.034 ↗
27. Iacovita C, Stiufiuc R, Radu T, Florea A, Stiufiuc G, Dutu A et al (2015) Polyethylene glycol-mediated synthesis of cubic iron oxide nanoparticles with high heating power. Nanoscale Res Lett 10:1–1610.1186/s11671-015-1091-0 ↗
28. Ge J, Hu Y, Biasini M, Beyermann WP, Yin Y (2007) Superparamagnetic magnetite colloidal nanocrystal clusters. Angew Chem Int Ed 46:4342–434510.1002/anie.200700197 ↗
29. Qu S, Yang H, Ren D, Kan S, Zou G, Li D et al (1999) Magnetite nanoparticles prepared by precipitation from partially reduced ferric chloride aqueous solutions. J Colloid Interface Sci 215:190–19210.1006/jcis.1999.6185 ↗
30. Özdemir Ö, Dunlop DJ, Moskowitz BM (2002) Changes in remanence, coercivity and domain state at low temperature in magnetite. Earth Planet Sci Lett 194:343–35810.1016/S0012-821X(01)00562-3 ↗
31. Bard AJ, Faulkner LR (2001) Fundamentals and applications. Electrochemical methods 2:580–632
32. Ahmed M, Ali S, El-Dek S, Galal A (2013) Magnetite–hematite nanoparticles prepared by green methods for heavy metal ions removal from water. Mater Sci Eng, B 178:744–75110.1016/j.mseb.2013.03.011 ↗
33. Chowdhury SR, Yanful EK, Pratt AR (2012) Chemical states in XPS and Raman analysis during removal of Cr (VI) from contaminated water by mixed maghemite–magnetite nanoparticles. J Hazard Mater 235:246–25610.1016/j.jhazmat.2012.07.054 ↗
34. Gobry V, Bouchard G, Carrupt PA, Testa B, Girault HH (2000) Physicochemical characterization of sildenafil: ionization, lipophilicity behavior, and ionic-partition diagram studied by two-phase titration and electrochemistry. Helv Chim Acta 83:1465–147410.1002/1522-2675(20000705)83:7<1465::AID-HLCA1465>3.0.CO;2-# ↗
35. Rajput S, Pittman CU Jr, Mohan D (2016) Magnetic magnetite (Fe3O4) nanoparticle synthesis and applications for lead (Pb2+) and chromium (Cr6+) removal from water. J Colloid Interface Sci 468:334–34610.1016/j.jcis.2015.12.008 ↗
36. Soleymani J, Hasanzadeh M, Shadjou N, Jafari MK, Gharamaleki JV, Yadollahi M et al (2016) A new kinetic–mechanistic approach to elucidate electrooxidation of doxorubicin hydrochloride in unprocessed human fluids using magnetic graphene based nanocomposite modified glassy carbon electrode. Mater Sci Eng, C 61:638–65010.1016/j.msec.2016.01.003 ↗
37. Laviron E (1979) General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems. J Electroanal Chem Interfacial Electrochem 101:19–2810.1016/S0022-0728(79)80075-3 ↗
38. W. Horwitz and R. Albert, Quality IssuesThe concept of uncertainty as applied to chemical measurements, Analyst, vol. 122, pp. 615-617, 1997.10.1039/a703178e ↗
39. J. Lović, N. Trišović, J. Antanasijević, and M. AvravomIvić, Electrochemical behaviour of sildenafil citrate at gold and cystein modified gold electrode in acid solution, Journal of Electrochemical Science and Engineering, vol. 8, pp. 163-170, 2018.10.5599/jese.481 ↗
40. L. M. Ochiai, E. H. Bindewald, P. Mengarda, L. H. Marcolino-Junior, and M. F. Bergamini, Disposable potentiometric citrate sensor based on polypyrrole-doped films for indirect determination of sildenafil in pharmaceuticals formulations, Journal of Applied Polymer Science, vol. 133, 2016.10.1002/app.43762 ↗
41. detection and quantification of sildenafil citrate and acetaminophen (2014) F. G. Delolo, C. Rodrigues, M. M. d. Silva, L. R. Dinelli, F. N. Delling, J. Zukerman-Schpector, et al., A new electrochemical sensor containing a film of chitosan-supported ruthenium. J Braz Chem Soc 25:550–559