Metal nanoparticles: a platform integrating diagnosis and therapy for rheumatoid arthritis
Source abstract
Abstract
Rheumatoid arthritis is a chronic and systemic autoimmune disease with aggressive and symmetrical polyarthritis as the main clinical manifestation, which has a considerably high incidence and mortality. In clinics, traditional drug therapy often produces toxicity to gastrointestinal and immunosuppression-mediated infection, which has greatly promoted the research and application of drugs based on nanomaterials in the diagnosis and treatment of rheumatoid arthritis. In recent years, nanotechnology has shown great advantages in developing novel therapeutic and diagnostic systems in the field of inflammation-related diseases. Among them, metal nanoparticles can be applied as therapeutic agents and drug delivery vectors for the treatment of rheumatoid arthritis (RA), as well as achieve quantitative analysis of RA markers rapidly attributed to the extra optical and magnetic effects of metal nanoparticles. The purpose of this review is to introduce the application of metal nanoparticles in rheumatoid arthritis, focusing on its latest progress, challenges, and future development prospects.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Rheumatoid Arthritis Research and Therapies · Monoclonal and Polyclonal Antibodies Research · Systemic Lupus Erythematosus Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Adebayo OA, Akinloye O, Adaramoye OA (2020) Cerium oxide nanoparticles attenuate oxidative stress and inflammation in the liver of diethylnitrosamine-treated mice. Biol Trace Elem Res 193:214–22510.1007/s12011-019-01696-5 ↗
2. Aggarwal R, Rider L, Ruperto N, Bayat N, Erman B et al (2017) 2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: an International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. Ann Rheum Dis 76:792–80110.1136/annrheumdis-2017-211400 ↗
3. Alaniz L, Cabrera PV, Blanco G, Ernst G, Rimoldi G et al (2002) Interaction of CD44 with different forms of hyaluronic acid. Its role in adhesion and migration of tumor cells. Cell Commun Adhes 9:117–13010.1080/15419060214522 ↗
4. Alonso F, Moglie Y, Radivoy G (2015) Copper nanoparticles in click chemistry. Acc Chem Res 48:2516–252810.1021/acs.accounts.5b00293 ↗
5. Bae YH, Park K (2011) Targeted drug delivery to tumors: myths, reality and possibility. J Control Release 153:198–20510.1016/j.jconrel.2011.06.001 ↗
6. Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG et al (2012) Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol 4:3–1010.1093/jmcb/mjr042 ↗
7. Carneiro MFH, Machado ART, Antunes LMG, Souza TE, Freitas VA et al (2020) Gold-coated superparamagnetic iron oxide nanoparticles attenuate collagen-induced arthritis after magnetic targeting. Biol Trace Elem Res 194:502–51310.1007/s12011-019-01799-z ↗
8. Champion GD, Graham GG, Ziegler JB (1990) The gold complexes. Baillieres Clin Rheumatol 4:491–53410.1016/S0950-3579(05)80005-6 ↗
9. Chen L, Bao Y, Denstedt J, Zhang J (2016) Nanostructured bioluminescent sensor for rapidly detecting thrombin. Biosens Bioelectron 77:83–8910.1016/j.bios.2015.09.010 ↗
10. Chen X, Chang L, Li X, Huang J, Yang L et al (2018) Tc17/IL-17A up-regulated the expression of MMP-9 via NF-κB pathway in nasal epithelial cells of patients with chronic rhinosinusitis. Front Immunol 9:212110.3389/fimmu.2018.02121 ↗
11. Chung TW, Kim EY, Kim SJ, Choi HJ, Jang SB et al (2017) Sialyllactose suppresses angiogenesis by inhibiting VEGFR-2 activation, and tumor progression. Oncotarget 8:58152–5816210.18632/oncotarget.16192 ↗
12. Colebatch A, Edwards C, Østergaard M, van der Heijde D, Balint P et al (2013) EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis 72:804–81410.1136/annrheumdis-2012-203158 ↗
13. Colombo M, Sommaruga S, Mazzucchelli S, Polito L, Verderio P et al (2012) Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition. Angew Chem Int Ed Engl 51:496–49910.1002/anie.201106775 ↗
14. Costa Lima SA, Reis S (2015) Temperature-responsive polymeric nanospheres containing methotrexate and gold nanoparticles: a multi-drug system for theranostic in rheumatoid arthritis. Colloids Surf B Biointerfaces 133:378–38710.1016/j.colsurfb.2015.04.048 ↗
15. Dalziel K, Going G, Cartwright PH, Marks R, Beveridge GW, Rowell NR (1986) Treatment of chronic discoid lupus erythematosus with an oral gold compound (auranofin). Br J Dermatol 115:211–21610.1111/j.1365-2133.1986.tb05720.x ↗
16. Dams ET, Laverman P, Oyen WJ, Storm G, Scherphof GL et al (2000) Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes. J Pharmacol Exp Ther 292:1071–1079
17. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V (2012) PLGA-based nanoparticles: an overview of biomedical applications. J Control Release 161:505–52210.1016/j.jconrel.2012.01.043 ↗
18. Daou TJ, Li L, Reiss P, Josserand V, Texier I (2009) Effect of poly(ethylene glycol) length on the in vivo behavior of coated quantum dots. Langmuir 25:3040–304410.1021/la8035083 ↗
19. Dörner T, Strand V, Cornes P, Gonçalves J, Gulácsi L et al (2016) The changing landscape of biosimilars in rheumatology. Ann Rheum Dis 75:974–98210.1136/annrheumdis-2016-209166 ↗
20. Duan J, Dong J, Zhang T, Su Z, Ding J et al (2014) Polyethyleneimine-functionalized iron oxide nanoparticles for systemic siRNA delivery in experimental arthritis. Nanomedicine (lond) 9:789–80110.2217/nnm.13.217 ↗
21. Elbagory AM, Hussein AA, Meyer M (2019) The in vitro immunomodulatory effects of gold nanoparticles synthesized from Hypoxis hemerocallidea aqueous extract and hypoxoside on macrophage and natural killer cells. Int J Nanomedicine 14:9007–901810.2147/IJN.S216972 ↗
22. El-Sayed IH, Huang X, El-Sayed MA (2005) Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett 5:829–83410.1021/nl050074e ↗
23. El-Sharkawy RG, Taha RH, Ghanem HB (2020) Immobilization of novel inorganic nano-complexes onto MWCNT nanomaterials as a novel adsorbent and anti-inflammatory therapy in an induced model of rheumatoid arthritis. Nanotechnology 31:30570610.1088/1361-6528/ab851a ↗
24. Eustis S, el-Sayed MA (2006) Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes. Chem Soc Rev 35:209–21710.1039/B514191E ↗
25. Fang C, Zhang M (2009) Multifunctional magnetic nanoparticles for medical imaging applications. J Mater Chem 19:6258–626610.1039/b902182e ↗
26. Fathima JB, Pugazhendhi A, Venis R (2017) Synthesis and characterization of ZrO2 nanoparticles-antimicrobial activity and their prospective role in dental care. Microb Pathog 110:245–25110.1016/j.micpath.2017.06.039 ↗
27. Fearon U, Canavan M, Biniecka M, Veale DJ (2016) Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis. Nat Rev Rheumatol 12:385–39710.1038/nrrheum.2016.69 ↗
28. Gramoun A, Crowe LA, Maurizi L, Wirth W, Tobalem F et al (2014) Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages. Arthritis Res Ther 16:R13110.1186/ar4588 ↗
29. Gul A, Kunwar B, Mazhar M, Faizi S, Ahmed D et al (2018) Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-kappaB and iNOS activation. Int Immunopharmacol 59:310–31710.1016/j.intimp.2018.04.017 ↗
30. Guo L, Chen Y, Wang T, Yuan Y, Yang Y et al (2020) Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy. J Control Release 330:119–13110.1016/j.jconrel.2020.10.069 ↗
31. Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26:3995–402110.1016/j.biomaterials.2004.10.012 ↗
32. Gurunathan S, Kim JH (2018) Biocompatible gold nanoparticles ameliorate retinoic acid-induced cell death and induce differentiation in F9 teratocarcinoma stem cells. Nanomaterials (Basel) 8(6):396.10.3390/nano8060396 ↗
33. Hong J, Chen Y-F, Ma Y, Zhang F-F, Wang C-M, Ding Y (2018) Surface modifier effects on gold nanoprobe for the assay of matrix metalloproteinases. Advanced Biosystems 210.1002/adbi.201800115 ↗
34. Hornos Carneiro MF, Barbosa F Jr (2016) Gold nanoparticles: a critical review of therapeutic applications and toxicological aspects. J Toxicol Environ Health B Crit Rev 19:129–14810.1080/10937404.2016.1168762 ↗
35. Hu X, Sun A, Kang W, Zhou Q (2017) Strategies and knowledge gaps for improving nanomaterial biocompatibility. Environ Int 102:177–18910.1016/j.envint.2017.03.001 ↗
36. Huang X, Jain P, El-Sayed I, El-Sayed M (2007) Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. Nanomedicine (lond) 2:681–69310.2217/17435889.2.5.681 ↗
37. Huang YJ, Shiau AL, Chen SY, Chen YL, Wang CR et al (2012) Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering. Eur Cell Mater 23:170–18110.22203/eCM.v023a13 ↗
38. Hwang ET, Lee JH, Chae YJ, Kim YS, Kim BC et al (2008) Analysis of the toxic mode of action of silver nanoparticles using stress-specific bioluminescent bacteria. Small 4:746–75010.1002/smll.200700954 ↗
39. Hwang EY, Lee JH, Lim DW (2020) Anisotropic bimetallic core-satellite-poly(aniline) nanohybrids for detection of autoantibodies. Macromol Rapid Commun 41:e200033110.1002/marc.202000331 ↗
40. Ishihara T, Kubota T, Choi T, Higaki M (2009) Treatment of experimental arthritis with stealth-type polymeric nanoparticles encapsulating betamethasone phosphate. J Pharmacol Exp Ther 329:412–41710.1124/jpet.108.150276 ↗
41. Jain PK, El-Sayed MA (2007) Universal scaling of plasmon coupling in metal nanostructures: extension from particle pairs to nanoshells. Nano Lett 7:2854–285810.1021/nl071496m ↗
42. Janakiraman K, Krishnaswami V, Rajendran V, Natesan S, Kandasamy R (2018) Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights. Mater Today Commun 17:200–21310.1016/j.mtcomm.2018.09.011 ↗
43. Jhun J, Moon J, Ryu J, Shin Y, Lee S et al (2020) Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One 15:e024108010.1371/journal.pone.0241080 ↗
44. Jia Z, Lyu F, Zhang LC, Zeng S, Liang SX et al (2019) Pt nanoparticles decorated heterostructured g-C3N4/Bi2MoO6 microplates with highly enhanced photocatalytic activities under visible light. Sci Rep 9:763610.1038/s41598-019-42973-6 ↗
45. Kalashnikova I, Chung SJ, Nafiujjaman M, Hill ML, Siziba ME et al (2020) Ceria-based nanotheranostic agent for rheumatoid arthritis. Theranostics 10:11863–1188010.7150/thno.49069 ↗
46. Katz E, Willner I (2004) Integrated nanoparticle-biomolecule hybrid systems: synthesis, properties, and applications. Angew Chem Int Ed Engl 43:6042–610810.1002/anie.200400651 ↗
47. Kemp MM, Kumar A, Mousa S, Dyskin E, Yalcin M et al (2009) Gold and silver nanoparticles conjugated with heparin derivative possess anti-angiogenesis properties. Nanotechnology 20:45510410.1088/0957-4484/20/45/455104 ↗
48. Kennedy A, Fearon U, Veale D, Godson C (2011) Macrophages in synovial inflammation. Front Immunol 2:5210.3389/fimmu.2011.00052 ↗
49. Khan MA, Khan MJ (2018) Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity. Artif Cells Nanomed Biotechnol 46:1149–115810.1080/21691401.2018.1446968 ↗
50. Khoury M, Escriou V, Courties G, Galy A, Yao R et al (2008) Efficient suppression of murine arthritis by combined anticytokine small interfering RNA lipoplexes. Arthritis Rheum 58:2356–236710.1002/art.23660 ↗
51. Kim KS, Park S-J, Lee M-Y, Lim K-G, Hahn SK (2012a) Gold half-shell coated hyaluronic acid-doxorubicin conjugate micelles for theranostic applications. Macromol Res 20:277–28210.1007/s13233-012-0062-x ↗
52. Kim CK, Kim T, Choi IY, Soh M, Kim D et al (2012b) Ceria nanoparticles that can protect against ischemic stroke. Angew Chem Int Ed Engl 51:11039–1104310.1002/anie.201203780 ↗
53. Kim H, Lee S, Park K, Mun C, Park Y, Yoo K (2015) Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis. Biomaterials 61:95–10210.1016/j.biomaterials.2015.05.018 ↗
54. Kim J, Kim HY, Song SY, Go SH, Sohn HS et al (2019) Synergistic oxygen generation and reactive oxygen species scavenging by manganese ferrite/ceria co-decorated nanoparticles for rheumatoid arthritis treatment. ACS Nano 13:3206–321710.1021/acsnano.8b08785 ↗
55. Kwon HJ, Cha MY, Kim D, Kim DK, Soh M et al (2016) Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer’s disease. ACS Nano 10:2860–287010.1021/acsnano.5b08045 ↗
56. Lee SM, Kim HJ, Ha YJ, Park YN, Lee SK et al (2013) Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles. ACS Nano 7:50–5710.1021/nn301215q ↗
57. Lee H, Lee MY, Bhang SH, Kim BS, Kim YS et al (2014) Hyaluronate-gold nanoparticle/tocilizumab complex for the treatment of rheumatoid arthritis. ACS Nano 8:4790–479810.1021/nn500685h ↗
58. Leech M, Metz C, Hall P, Hutchinson P, Gianis K et al (1999) Macrophage migration inhibitory factor in rheumatoid arthritis: evidence of proinflammatory function and regulation by glucocorticoids. Arthritis Rheum 42:1601–160810.1002/1529-0131(199908)42:8<1601::AID-ANR6>3.0.CO;2-B ↗
59. Li S, Zhang R, Li P, Yi W, Zhang Z et al (2008) Development of a novel method to measure macrophage migration inhibitory factor (MIF) in sera of patients with rheumatoid arthritis by combined electrochemical immunosensor. Int Immunopharmacol 8:859–86510.1016/j.intimp.2008.01.032 ↗
60. Li J, Chen L, Xu X, Fan Y, Xue X et al (2020) Targeted combination of antioxidative and anti-inflammatory therapy of rheumatoid arthritis using multifunctional dendrimer-entrapped gold nanoparticles as a platform. Small 16:e200566110.1002/smll.202005661 ↗
61. Lin W, Huang Y, Zhou X, Ma Y (2006) Toxicity of cerium oxide nanoparticles in human lung cancer cells. Int J Toxicol 25:451–45710.1080/10915810600959543 ↗
62. Lin L, Tian X, Hong S, Dai P, You Q et al (2013) A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells. Angew Chem Int Ed Engl 52:7266–727110.1002/anie.201301387 ↗
63. Link S, El-Sayed M (2003) Optical properties and ultrafast dynamics of metallic nanocrystals. Annu Rev Phys Chem 54:331–36610.1146/annurev.physchem.54.011002.103759 ↗
64. Liu S, Maeyama K (2016) Gene therapy for rheumatoid arthritis. Crit Rev Immunol 36:149–16110.1615/CritRevImmunol.2016017062 ↗
65. Liu YM, Mei L, Liu YY, Zhou M, Huang KJ et al (2014) Highly sensitive capillary electrophoretic immunoassay of rheumatoid factor in human serum with gold nanoparticles enhanced chemiluminescence detection. Electrophoresis 35:972–97710.1002/elps.201300524 ↗
66. Lu AH, Salabas EL, Schüth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed Engl 46:1222–124410.1002/anie.200602866 ↗
67. Luo Y, Zheng SG (2016) Hall of fame among pro-inflammatory cytokines: interleukin-6 gene and its transcriptional regulation mechanisms. Front Immunol 7:60410.3389/fimmu.2016.00604 ↗
68. Maldiney T, Richard C, Seguin J, Wattier N, Bessodes M, Scherman D (2011) Effect of core diameter, surface coating, and PEG chain length on the biodistribution of persistent luminescence nanoparticles in mice. ACS Nano 5:854–86210.1021/nn101937h ↗
69. Malemud CJ (2017) Matrix metalloproteinases and synovial joint pathology. Prog Mol Biol Transl Sci 148:305–32510.1016/bs.pmbts.2017.03.003 ↗
70. McInnes IB, Schett G (2017) Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 389:2328–233710.1016/S0140-6736(17)31472-1 ↗
71. Morand EF, Leech M, Weedon H, Metz C, Bucala R, Smith MD (2002) Macrophage migration inhibitory factor in rheumatoid arthritis: clinical correlations. Rheumatology (oxford) 41:558–56210.1093/rheumatology/41.5.558 ↗
72. Moura CC, Segundo MA, Neves J, Reis S, Sarmento B (2014) Co-association of methotrexate and SPIONs into anti-CD64 antibody-conjugated PLGA nanoparticles for theranostic application. Int J Nanomedicine 9:4911–4922
73. Mukherjee P, Bhattacharya R, Wang P, Wang L, Basu S et al (2005) Antiangiogenic properties of gold nanoparticles. Clin Cancer Res 11:3530–353410.1158/1078-0432.CCR-04-2482 ↗
74. Nagarajan D, Venkatanarasimhan S (2019) Copper(II) oxide nanoparticles coated cellulose sponge-an effective heterogeneous catalyst for the reduction of toxic organic dyes. Environ Sci Pollut Res Int 26:22958–2297010.1007/s11356-019-05419-0 ↗
75. Nethi S, Mukherjee S, Veeriah V, Barui A, Chatterjee S, Patra C (2014) Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signaling. Chem Commun (camb) 50:14367–1437010.1039/C4CC06996J ↗
76. Niza E, Božik M, Bravo I, Clemente-Casares P, Lara-Sanchez A et al (2020) PEI-coated PLA nanoparticles to enhance the antimicrobial activity of carvacrol. Food Chem 328:12713110.1016/j.foodchem.2020.127131 ↗
77. O’Neil LJ, Kaplan MJ (2019) Neutrophils in rheumatoid arthritis: breaking immune tolerance and fueling disease. Trends Mol Med 25:215–22710.1016/j.molmed.2018.12.008 ↗
78. Pan Y, Neuss S, Leifert A, Fischler M, Wen F et al (2007) Size-dependent cytotoxicity of gold nanoparticles. Small 3:1941–194910.1002/smll.200700378 ↗
79. Pan Y, Wu Q, Liu R, Shao M, Pi J et al (2014) Inhibition effects of gold nanoparticles on proliferation and migration in hepatic carcinoma-conditioned HUVECs. Bioorg Med Chem Lett 24:679–68410.1016/j.bmcl.2013.11.045 ↗
80. Pandey PK, Maheshwari R, Raval N, Gondaliya P, Kalia K, Tekade RK (2019) Nanogold-core multifunctional dendrimer for pulsatile chemo-, photothermal- and photodynamic- therapy of rheumatoid arthritis. J Colloid Interface Sci 544:61–7710.1016/j.jcis.2019.02.073 ↗
81. Peng R, Si Y, Deng T, Zheng J, Li J et al (2016) A novel SERS nanoprobe for the ratiometric imaging of hydrogen peroxide in living cells. Chem Commun (camb) 52:8553–855610.1039/C6CC03412H ↗
82. Pereira D, Petronilho F, Pereira H, Vuolo F, Mina F et al (2012) Effects of gold nanoparticles on endotoxin-induced uveitis in rats. Invest Ophthalmol vis Sci 53:8036–804110.1167/iovs.12-10743 ↗
83. Phull AR, Nasir B, Haq IU, Kim SJ (2018) Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis. Chem Biol Interact 281:121–13610.1016/j.cbi.2017.12.024 ↗
84. Radstake TR, Sweep FC, Welsing P, Franke B, Vermeulen SH et al (2005) Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor. Arthritis Rheum 52:3020–302910.1002/art.21285 ↗
85. Ramil CP, Lin Q (2013) Bioorthogonal chemistry: strategies and recent developments. Chem Commun (camb) 49:11007–1102210.1039/c3cc44272a ↗
86. Rao K, Aziz S, Roome T, Razzak A, Sikandar B et al (2018) Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats. Artif Cells Nanomed Biotechnol 46:597–60710.1080/21691401.2018.1431653 ↗
87. Roome T, Aziz S, Razzak A, Aslam Z, Lubna, et al (2019) Opuntioside, opuntiol and its metallic nanoparticles attenuate adjuvant-induced arthritis: novel suppressors of Toll-like receptors-2 and -4. Biomed Pharmacother 112:10862410.1016/j.biopha.2019.108624 ↗
88. Saravanakumar G, Kim J, Kim WJ (2017) Reactive-oxygen-species-responsive drug delivery systems: promises and challenges. Adv Sci (weinh) 4:160012410.1002/advs.201600124 ↗
89. Sathiyavimal S, Vasantharaj S, Bharathi D, Saravanan M, Manikandan E et al (2018) Biogenesis of copper oxide nanoparticles (CuONPs) using Sida acuta and their incorporation over cotton fabrics to prevent the pathogenicity of Gram negative and Gram positive bacteria. J Photochem Photobiol B 188:126–13410.1016/j.jphotobiol.2018.09.014 ↗
90. Shin JM, Kim SH, Thambi T, You DG, Jeon J et al (2014) A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis. Chem Commun (camb) 50:7632–763510.1039/c4cc02595d ↗
91. Sisubalan N, Ramkumar VS, Pugazhendhi A, Karthikeyan C, Indira K et al (2018) ROS-mediated cytotoxic activity of ZnO and CeO2 nanoparticles synthesized using the Rubia cordifolia L. leaf extract on MG-63 human osteosarcoma cell lines. Environ Sci Pollut Res Int 25:10482–1049210.1007/s11356-017-0003-5 ↗
92. Soh M, Kang DW, Jeong HG, Kim D, Kim DY et al (2017) Ceria-zirconia nanoparticles as an enhanced multi-antioxidant for sepsis treatment. Angew Chem Int Ed Engl 56:11399–1140310.1002/anie.201704904 ↗
93. Sokolov K, Follen M, Aaron J, Pavlova I, Malpica A et al (2003) Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res 63:1999–2004
94. Sperling RA, Parak WJ (2010) Surface modification, functionalization and bioconjugation of colloidal inorganic nanoparticles. Philos Trans A Math Phys Eng Sci 368:1333–1383
95. Srikanth K, Trindade T, Duarte AC, Pereira E (2017) Cytotoxicity and oxidative stress responses of silica-coated iron oxide nanoparticles in CHSE-214 cells. Environ Sci Pollut Res Int 24:2055–206410.1007/s11356-016-7870-z ↗
96. Subhan MA, Torchilin VP (2019) Efficient nanocarriers of siRNA therapeutics for cancer treatment. Transl Res 214:62–9110.1016/j.trsl.2019.07.006 ↗
97. Suh KS, Lee YS, Seo SH, Kim YS, Choi EM (2013) Gold nanoparticles attenuates antimycin A-induced mitochondrial dysfunction in MC3T3-E1 osteoblastic cells. Biol Trace Elem Res 153:428–43610.1007/s12011-013-9679-7 ↗
98. Sumbayev VV, Yasinska IM, Garcia CP, Gilliland D, Lall GS et al (2013) Gold nanoparticles downregulate interleukin-1beta-induced pro-inflammatory responses. Small 9:472–47710.1002/smll.201201528 ↗
99. Svendsen AJ, Junker P, Houen G, Kyvik KO, Nielsen C et al (2017) Incidence of chronic persistent rheumatoid arthritis and the impact of smoking: a historical twin cohort study. Arthritis Care Res (hoboken) 69:616–62410.1002/acr.22987 ↗
100. Tatiparti K, Sau S, Kashaw SK, Iyer AK (2017) siRNA delivery strategies: a comprehensive review of recent developments. Nanomaterials (Basel) 710.3390/nano7040077 ↗