Theranostic nanoplatform based on polypyrrole nanoparticles for photoacoustic imaging and photothermal therapy
Source abstract
Abstract
Development of effective theranostic nanoplatforms against malignant tumor is still a challenge. With desirable near-infrared (NIR) light-responsive properties, polypyrrole nanoparticles (PPy NPs) are one of the promising theranostic candidates for cancer photoacoustic imaging and photothermal therapy. Here, PPy NPs with distinct sizes were prepared using a facile aqueous dispersion polymerization method. The formed PPy NPs are uniform in size with narrow size distribution. Characterization data show that PPy NPs with a diameter around 50 nm (P50) display stronger absorption in the NIR range compared to 40 and 60 nm PPy NPs, which further influences their photo-responsive properties. Due to their higher NIR absorption, P50 NPs have better photoacoustic imaging property and photothermal conversion ability than the other two kinds of PPy NPs. The photothermal stability of P50 NPs was proved to be excellent. The CCK-8 assays show that PPy NPs have obvious acute cytotoxicity within 6 h and desirable cytocompatibility for longer incubation time (12 and 24 h). After 6-h incubation, P50 NPs could be internalized by HeLa cells. Their photothermal tumor ablation effect was demonstrated under 808-nm laser irradiation. These findings may provide in-depth understanding of the PPy-based multifunctional nanomaterials for the development of theranostic systems against cancer.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Ahmad R, Fu J, He N, Li S (2016) Advanced gold nanomaterials for photothermal therapy of cancer. J Nanosci Nanotechno 16(1):67–8010.1166/jnn.2016.10770 ↗
2. Cai H, Li K, Shen M, Wen S, Luo Y, Peng C, Zhang G, Shi X (2012) Facile assembly of Fe3O4@Au nanocomposite particles for dual mode magnetic resonance and computed tomography imaging applications. J Mater Chem 22(30):1511010.1039/c2jm16851k ↗
3. Chen M, Fang X, Tang S, Zheng N (2012) Polypyrrole nanoparticles for high-performance in vivo near-infrared photothermal cancer therapy. Chem Commun 48(71):8934–893610.1039/c2cc34463g ↗
4. Chen D, Wang C, Nie X, Li S, Li R, Guan M, Liu Z, Chen C, Wang C, Shu C, Wan L (2014a) Photoacoustic imaging guided near-infrared photothermal therapy using highly water-dispersible single-walled carbon nanohorns as theranostic agents. Adv Funct Mater 24(42):6621–662810.1002/adfm.201401560 ↗
5. Chen M, Tang S, Guo Z, Wang X, Mo S, Huang X, Liu G, Zheng N (2014b) Core-shell Pd@Au nanoplates as theranostic agents for in-vivo photoacoustic imaging, CT imaging, and photothermal therapy. Adv Mater 26(48):8210–821610.1002/adma.201404013 ↗
6. Cheng L, Liu J, Gu X, Gong H, Shi X, Liu T, Wang C, Wang X, Liu G, Xing H, Bu W, Sun B, Liu Z (2014) PEGylated WS2 nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy. Adv Mater 26(12):1886–189310.1002/adma.201304497 ↗
7. Deng H, Dai F, Ma G, Zhang X (2015) Theranostic gold nanomicelles made from biocompatible comb-like polymers for thermochemotherapy and multifunctional imaging with rapid clearance. Adv Mater 27(24):3645–365310.1002/adma.201501420 ↗
8. Dong Z, Gong H, Gao M, Zhu W, Sun X, Feng L, Fu T, Li Y, Liu Z (2016) Polydopamine nanoparticles as a versatile molecular loading platform to enable imaging-guided cancer combination therapy. Theranostics 6(7):1031–104210.7150/thno.14431 ↗
9. Fan Q, Cheng K, Yang Z, Zhang R, Yang M, Hu X, Ma X, Bu L, Lu X, Xiong X, Huang W, Zhao H, Cheng Z (2015) Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice. Adv Mater 27(5):843–84710.1002/adma.201402972 ↗
10. Guha S, Shaw GK, Mitcham TM, Bouchard RR, Smith BD (2016) Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH. Chem Commun 52(1):120–12310.1039/C5CC08317F ↗
11. Hong J-Y, Yoon H, Jang J (2010) Kinetic study of the formation of polypyrrole nanoparticles in water-soluble polymer/metal cation systems: a light-scattering analysis. Small 6(5):679–68610.1002/smll.200902231 ↗
12. Hu D, Liu C, Song L, Cui H, Gao G, Liu P, Sheng Z, Cai L (2016a) Indocyanine green-loaded polydopamine-iron ions coordination nanoparticles for photoacoustic/magnetic resonance dual-modal imaging-guided cancer photothermal therapy. Nano 8(39):17150–17158
13. Hu D, Zhang J, Gao G, Sheng Z, Cui H, Cai L (2016b) Indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites with amplifying photoacoustic and photothermal effects for cancer theranostics. Theranostics 6(7):1043–105210.7150/thno.14566 ↗
14. Huang Y, He S, Cao W, Cai K, Liang XJ (2012) Biomedical nanomaterials for imaging-guided cancer therapy. Nano 4(20):6135–6149
15. Huang P, Lin J, Li W, Rong P, Wang Z, Wang S, Wang X, Sun X, Aronova M, Niu G (2013) Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy. Angew Chem Int Edit 125(52):14208–1421410.1002/ange.201308986 ↗
16. Jin Y, Li Y, Ma X, Zha Z, Shi L, Tian J, Dai Z (2014) Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer. Biomaterials 35(22):5795–580410.1016/j.biomaterials.2014.03.086 ↗
17. Li Y, Jiang C, Zhang D, Wang Y, Ren X, Ai K, Chen X, Lu L (2017) Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. Acta Biomater 47:124–13410.1016/j.actbio.2016.10.010 ↗
18. Liang X, Li Y, Li X, Jing L, Deng Z, Yue X, Li C, Dai Z (2015) PEGylated polypyrrole nanoparticles conjugating gadolinium chelates for dual-modal MRI/photoacoustic imaging guided photothermal therapy of cancer. Adv Funct Mater 25(9):1451–146210.1002/adfm.201402338 ↗
19. Liang X, Fang L, Li X, Zhang X, Wang F (2017) Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy. Biomaterials 132:72–8410.1016/j.biomaterials.2017.04.006 ↗
20. Liao J, Qi T, Chu B, Peng J, Luo F, Qian Z (2014) Multifunctional nanostructured materials for multimodal cancer imaging and therapy. J Nanosci Nanotechno 14(1):175–18910.1166/jnn.2014.9049 ↗
21. Liu H, Wang H, Xu Y, Shen M, Zhao J, Zhang G, Shi X (2014) Synthesis of PEGylated low generation dendrimer-entrapped gold nanoparticles for CT imaging applications. Nano 6:4521–4526
22. Liu F, He X, Lei Z, Liu L, Zhang J, You H, Zhang H, Wang Z (2015) Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy. Adv Healthcare Mater 4(4):559–56810.1002/adhm.201400676 ↗
23. Opoku-Damoah Y, Wang R, Zhou J, Ding Y (2016) Versatile nanosystem-based cancer theranostics: design inspiration and predetermined routing. Theranostics 6(7):986–100310.7150/thno.14860 ↗
24. Song KH, Stein EW, Margenthaler JA, Wang LV (2008) Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model. J Biomed Opt 13(5):05403310.1117/1.2976427 ↗
25. Song G, Shen J, Jiang F, Hu R, Li W, An L, Zou R, Chen Z, Qin Z, Hu J (2014) Hydrophilic molybdenum oxide nanomaterials with controlled morphology and strong plasmonic absorption for photothermal ablation of cancer cells. ACS Appl Mater Inter 6(6):3915–392210.1021/am4050184 ↗
26. Song X, Chen Q, Liu Z (2015) Recent advances in the development of organic photothermal nano-agents. Nano Res 8(2):340–35410.1007/s12274-014-0620-y ↗
27. Wang X, Pang Y, Ku G, Xie X, Stoica G, Wang LV (2003) Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain. Nat Biotechnol 21(7):803–80610.1038/nbt839 ↗
28. Wang K, Gao Z, Gao G, Wo Y, Wang Y, Shen G, Cui D (2013) Systematic safety evaluation on photoluminescent carbon dots. Nanoscale Res Lett 8(1):12210.1186/1556-276X-8-122 ↗
29. Wang L, Lin X, Wang J, Hu Z, Ji Y, Hou S, Zhao Y, Wu X, Chen C (2014a) Novel insights into combating cancer chemotherapy resistance using a plasmonic nanocarrier: enhancing drug sensitiveness and accumulation simultaneously with localized mild photothermal stimulus of femtosecond pulsed laser. Adv Funct Mater 24(27):4229–423910.1002/adfm.201400015 ↗
30. Wang Q, Wang J, Lv G, Wang F, Zhou X, Hu J, Wang Q (2014b) Facile synthesis of hydrophilic polypyrrole nanoparticles for photothermal cancer therapy. J Mater Sci 49(9):3484–349010.1007/s10853-014-8061-2 ↗
31. Wang L, Sun Q, Wang X, Wen T, Yin J, Wang P, Bai R, Zhang X, Zhang L, Lu A, Chen C (2015) Using hollow carbon nanospheres as a light-induced free radical generator to overcome chemotherapy resistance. J Am Chem Soc 137(5):1947–195510.1021/ja511560b ↗
32. Wang S, Zhao J, Yang H, Wu C, Hu F, Chang H, Li G, Ma D, Zou D, Huang M (2017) Bottom-up synthesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression. Acta Biomater 58:442–45410.1016/j.actbio.2017.06.014 ↗
33. Wen S, Li K, Cai H, Chen Q, Shen M, Huang Y, Peng C, Hou W, Zhu M, Zhang G, Shi X (2013) Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging applications. Biomaterials 34(5):1570–158010.1016/j.biomaterials.2012.11.010 ↗
34. Yang K, Feng L, Shi X, Liu Z (2013) Nano-graphene in biomedicine: theranostic applications. Chem Soc Rev 42(2):530–54710.1039/C2CS35342C ↗
35. Yang Z, Ren J, Ye Z, Zhu W, Xiao L, Zhang L, He Q, Xu Z, Xu H (2017) Bio-inspired synthesis of PEGylated polypyrrole@polydopamine nanocomposites as theranostic agents for T1-weighted MR imaging guided photothermal therapy. J Mater Chem B 5(5):1108–111610.1039/C6TB02740G ↗
36. Zha Z, Deng Z, Li Y, Li C, Wang J, Wang S, Qu E, Dai Z (2013a) Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging. Nano 5(10):4462–4467
37. Zha Z, Yue X, Ren Q, Dai Z (2013b) Uniform polypyrrole nanoparticles with high photothermal conversion efficiency for photothermal ablation of cancer cells. Adv Mater 25(5):777–78210.1002/adma.201202211 ↗
38. Zha Z, Zhang S, Deng Z, Li Y, Li C, Dai Z (2013c) Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy. Chem Commun 49(33):3455–345710.1039/c3cc40608c ↗
39. Zhang L, Su H, Cai J, Cheng D, Ma Y, Zhang J, Zhou C, Liu S, Shi H, Zhang Y, Zhang C (2016) A multifunctional platform for tumor angiogenesis-targeted chemo-thermal therapy using polydopamine-coated gold nanorods. ACS Nano 10(11):10404–1041710.1021/acsnano.6b06267 ↗