Self-microemulsifying delivery system for improving bioavailability of water insoluble drugs
Source abstract
Abstract
Self-microemulsifying drug delivery system (SMEDDS) is a uniform and transparent solution consisting of oil phase, surfactant, co-surfactant, and a small amount of water. It could be orally administered under gastrointestinal peristalsis and spontaneously dispersed to form an oil-in-water microemulsion with typical particle sizes lower than 100 nm. The microemulsion forms a hydration layer that easily passes through the gastrointestinal wall, which increases the permeability to intestinal epithelial cells, thereby increasing the solubility of poorly soluble drugs and significantly improving bioavailability. This paper mainly introduces the main factors of improving bioavailability of microemulsion delivery system, the application of SMEDDS, and the characteristics of SMEDDS in vivo and in vitro. Finally, it summarizes the current prospects of SMEDDS in this field and the challenges ahead.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Drug Solubulity and Delivery Systems · Surfactants and Colloidal Systems · Advanced Drug Delivery Systems
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (69)
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1. Akula S, Gurram AK, Devireddy SR, Deshpande PB (2015) Evaluation of surfactant effect on self micro emulsifying drug delivery system (smedds) of lercanidipine hydrochloride: formulation and evaluation. J Pharm Innov 10(4):374–387. https://doi.org/10.1007/s12247-015-9233-610.1007/s12247-015-9233-6 ↗
2. Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, Kim DD, Jee JP, Lee YB, .Woo JS, Yong CS, Choi HG (2009) Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm 374(1–2):66–72. https://doi.org/10.1016/j.ijpharm.2009.03.00810.1016/j.ijpharm.2009.03.008 ↗
3. Bolko Seljak K, Ilic IG, Gasperlin M, Zvonar Pobirk A (2018) Self-microemulsifying tablets prepared by direct compression for improved resveratrol delivery. Int J Pharm 548(1):263–275. https://doi.org/10.1016/j.ijpharm.2018.06.06510.1016/j.ijpharm.2018.06.065 ↗
4. Callender SP, Mathews JA, Kobernyk K, Wettig SD (2017) Microemulsion utility in pharmaceuticals: implications for multi-drug delivery. Int J Pharm 526(1–2):425–442. https://doi.org/10.1016/j.ijpharm.2017.05.00510.1016/j.ijpharm.2017.05.005 ↗
5. Cerpnjak K, Pobirk AZ, Vrecer F, Gasperlin M (2015a) Tablets and minitablets prepared from spray-dried smedds containing naproxen. Int J Pharm 495(1):336–346. https://doi.org/10.1016/j.ijpharm.2015.08.09910.1016/j.ijpharm.2015.08.099 ↗
6. Cerpnjak K, Zvonar A, Vrecer F, Gasperlin M (2015b) Development of a solid self-microemulsifying drug delivery system (smedds) for solubility enhancement of naproxen. Drug Dev Ind Pharm 41(9):1548–1557. https://doi.org/10.3109/03639045.2014.97103110.3109/03639045.2014.971031 ↗
7. Chatterjee B, Hamed Almurisi S, Ahmed Mahdi Dukhan A, Mandal UK, Sengupta P (2016) Controversies with self-emulsifying drug delivery system from pharmacokinetic point of view. Drug Deliv 23(9):3639–3652. https://doi.org/10.1080/10717544.2016.121499010.1080/10717544.2016.1214990 ↗
8. Chaudhari KS, Akamanchi KG (2019) Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz. Int J Pharm 560:205–218. https://doi.org/10.1016/j.ijpharm.2019.01.06510.1016/j.ijpharm.2019.01.065 ↗
9. Cheng G, Hu R, Ye L, Wang B, Gui Y, Gao S, Li X, Tang J (2016) Preparation and in vitro/in vivo evaluation of puerarin solid self-microemulsifying drug delivery system by spherical crystallization technique. AAPS PharmSciTech 17(6):1336–1346. https://doi.org/10.1208/s12249-015-0469-810.1208/s12249-015-0469-8 ↗
10. Chen L, Liu CS, Chen QZ, Wang S, Xiong YA, Jing J, Lv J (2017) Characterization, pharmacokinetics and tissue distribution of chlorogenic acidloaded self-microemulsifying drug delivery system. Eur J Pharm Sci 100:102–108. https://doi.org/10.1016/j.ejps.2017.01.01110.1016/j.ejps.2017.01.011 ↗
11. Cherniakov I, Domb AJ, Hoffman A (2015) Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects. Expert Opin Drug Deliv 12(7):1121–1133. https://doi.org/10.1517/17425247.2015.99903810.1517/17425247.2015.999038 ↗
12. Cirri M, Roghi A, Valleri M, Mura P (2016) Development and characterization of fast-dissolving tablet formulations of glyburide based on solid self-microemulsifying systems. Eur J Pharm Biopharm 104:19–29. https://doi.org/10.1016/j.ejpb.2016.04.00810.1016/j.ejpb.2016.04.008 ↗
13. Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H, Zhai G (2009) Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 371(1–2):148–155. https://doi.org/10.1016/j.ijpharm.2008.12.00910.1016/j.ijpharm.2008.12.009 ↗
14. Dangre P, Gilhotra R, Dhole S (2016) Formulation and statistical optimization of self-microemulsifying drug delivery system of eprosartan mesylate for improvement of oral bioavailability. Drug Deliv Transl Res 6(5):610–621. https://doi.org/10.1007/s13346-016-0318-710.1007/s13346-016-0318-7 ↗
15. Djekic L, Jankovic J, Calija B, Primorac M (2017) Development of semisolid self-microemulsifying drug delivery systems (smeddss) filled in hard capsules for oral delivery of aciclovir. Int J Pharm 528(1–2):372–380. https://doi.org/10.1016/j.ijpharm.2017.06.02810.1016/j.ijpharm.2017.06.028 ↗
16. Djekic L, Jankovic J, Raskovic A, Primorac M (2018) Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of acyclovir in rats. Eur J Pharm Sci 121:287–292. https://doi.org/10.1016/j.ejps.2018.06.00510.1016/j.ejps.2018.06.005 ↗
17. Du J, Zhou Y, Wang L, Zhao J, Liu Y, Li C, Wang Y (2018) Deacetyl mycoepoxydience nanocrystals dispersible tablets formulation and in vitro study. J Nanosci Nanotechnol 18(6):3850–3855. https://doi.org/10.1166/jnn.2018.1503110.1166/jnn.2018.15031 ↗
18. Ezrahi S, Aserin A, Garti N (2019) Basic principles of drug delivery systems - the case of paclitaxel. Adv Colloid Interf Sci 263:95–130. https://doi.org/10.1016/j.cis.2018.11.00410.1016/j.cis.2018.11.004 ↗
19. Gershanika T, Benitaa S (1996) Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone. Pharm Dev Technol No.2:147–15710.3109/10837459609029889 ↗
20. Ghadi R, Dand N (2017) Bcs class iv drugs: highly notorious candidates for formulation development. J Control Release 248:71–95. https://doi.org/10.1016/j.jconrel.2017.01.01410.1016/j.jconrel.2017.01.014 ↗
21. Goke K, Lorenz T, Repanas A, Schneider F, Steiner D, Baumann K et al (2018) Novel strategies for the formulation and processing of poorly water-soluble drugs. Eur J Pharm Biopharm 126:40–56. https://doi.org/10.1016/j.ejpb.2017.05.00810.1016/j.ejpb.2017.05.008 ↗
22. Hajjar B, Zier K-I, Khalid N, Azarmi S, Löbenberg R (2017) Evaluation of a microemulsion-based gel formulation for topical drug delivery of diclofenac sodium. J Pharm Investig 48:351–362. https://doi.org/10.1007/s40005-017-0327-710.1007/s40005-017-0327-7 ↗
23. He S, Cui Z, Wang X, Zhang H, Dai W, Zhang Q (2015) Cremophor-free intravenous self-microemulsions for teniposide: safety, antitumor activity in vitro and in vivo. Int J Pharm 495(1):144–153. https://doi.org/10.1016/j.ijpharm.2015.08.00510.1016/j.ijpharm.2015.08.005 ↗
24. Hintzen F, Perera G, Hauptstein S, Muller C, Laffleur F, Bernkop-Schnurch A (2014) In vivo evaluation of an oral self-microemulsifying drug delivery system (smedds) for leuprorelin. Int J Pharm 472(1–2):20–26. https://doi.org/10.1016/j.ijpharm.2014.05.04710.1016/j.ijpharm.2014.05.047 ↗
25. Hu X, Lin C, Chen D, Zhang J, Liu Z, Wu W, Song H (2012) Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation. Int J Pharm 438(1–2):123–133. https://doi.org/10.1016/j.ijpharm.2012.07.05510.1016/j.ijpharm.2012.07.055 ↗
26. Huang W, Su H, Wen L, Shao A, Yang F, Chen G (2018) Enhanced anticancer effect of brucea javanica oil by solidified self-microemulsifying drug delivery system. J Drug Deliv Sci Technol 48:266–273. https://doi.org/10.1016/j.jddst.2018.10.00110.1016/j.jddst.2018.10.001 ↗
27. Huo T, Tao C, Zhang M, Liu Q, Lin B, Liu Z, Zhang J, Zhang M, Yang H, Wu J, Sun X, Zhang Q, Song H (2018) Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation. Eur J Pharm Sci 114:74–83. https://doi.org/10.1016/j.ejps.2017.12.00210.1016/j.ejps.2017.12.002 ↗
28. Jain A, Kaur R, Beg S, Kushwah V, Jain S, Singh B (2018) Novel cationic supersaturable nanomicellar systems of raloxifene hydrochloride with enhanced biopharmaceutical attributes. Drug Deliv Transl Re 8(3):670–692. https://doi.org/10.1007/s13346-018-0514-810.1007/s11051-019-4744-610.1007/s13346-018-0514-810.1007/s11051-019-4744-6 ↗
29. Jaisamut P, Wiwattanawongsa K, Graidist P, Sangsen Y, Wiwattanapatapee R (2018) Enhanced oral bioavailability of curcumin using a supersaturatable self-microemulsifying system incorporating a hydrophilic polymer; in vitro and in vivo investigations. AAPS PharmSciTech 19(2):730–740. https://doi.org/10.1208/s12249-017-0857-310.1208/s12249-017-0857-3 ↗
30. Jiang F, Wu G, Li W, Yang J, Yan J, Wang Y, Yao W, Zhou X, He Z, Wu L, Xiao C, Xiao T, Zhang M, Shen X, Tao L (2019) Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice. Eur J Pharm Sci 127:14–23. https://doi.org/10.1016/j.ejps.2018.10.01210.1016/j.ejps.2018.10.012 ↗
31. Jing B, Wang Z, Yang R, Zheng X, Zhao J, Tang S, He Z (2016) Enhanced oral bioavailability of felodipine by novel solid self-microemulsifying tablets. Drug Dev Ind Pharm 42(3):506–512. https://doi.org/10.3109/03639045.2015.105881610.3109/03639045.2015.1058816 ↗
32. Kamal MM, Nazzal S (2018) Novel sulforaphane-enabled self-microemulsifying delivery systems (sfn-smedds) of taxanes: formulation development and in vitro cytotoxicity against breast cancer cells. Int J Pharm 536(1):187–198. https://doi.org/10.1016/j.ijpharm.2017.11.06310.1016/j.ijpharm.2017.11.063 ↗
33. Katla VM, Veerabrahma K (2016) Cationic solid self micro emulsifying drug delivery system (ssmed) of losartan: formulation development, characterization and in vivo evaluation. J Drug Deliv Sci Technol 35:190–199. https://doi.org/10.1016/j.jddst.2016.04.01110.1016/j.jddst.2016.04.011 ↗
34. Kim DW, Kwon MS, Yousaf AM, Balakrishnan P, Park JH, Kim DS, Lee BJ, Park YJ, Yong CS, Kim JO, Choi HG (2014) Comparison of a solid smedds and solid dispersion for enhanced stability and bioavailability of clopidogrel napadisilate. Carbohydr Polym 114:365–374. https://doi.org/10.1016/j.carbpol.2014.08.03410.1016/j.carbpol.2014.08.034 ↗
35. Kogan A, Aserin A, Garti N (2007) Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution. J Colloid Interface Sci 315(2):637–647. https://doi.org/10.1016/j.jcis.2007.06.08710.1016/j.jcis.2007.06.087 ↗
36. Kollipara S, Gandhi RK (2014) Pharmacokinetic aspects and in vitro-in vivo correlation potential for lipid-based formulations. Acta Pharm Sin B 4(5):333–349. https://doi.org/10.1016/j.apsb.2014.09.00110.1016/j.apsb.2014.09.001 ↗
37. Li L, Yi T, Lam CW (2013) Effects of spray-drying and choice of solid carriers on concentrations of labrasol(r) and transcutol(r) in solid self-microemulsifying drug delivery systems (smedds). Molecules 18(1):545–560. https://doi.org/10.3390/molecules1801054510.3390/molecules18010545 ↗
38. Li F, Hu R, Wang B, Gui Y, Cheng G, Gao S, Ye L, Tang J (2017) Self-microemulsifying drug delivery system for improving the bioavailability of huperzine a by lymphatic uptake. Acta Pharm Sin B 7(3):353–360. https://doi.org/10.1016/j.apsb.2017.02.00210.1016/j.apsb.2017.02.002 ↗
39. Liu Y, Zhao J, Wang L, Yan B, Gu Y, Chang P, Wang Y (2018) Nanocrystals technology for transdermal delivery of water-insoluble drugs. Curr Drug Deliv 15(9):1221–1229. https://doi.org/10.2174/156720181566618051812434510.2174/1567201815666180518124345 ↗
40. Liu Y, Wang Y, Zhao J (2019) Design, optimization and in vitro-in vivo evaluation of smart nanocaged carrier delivery of multifunctional peg-chitosan stabilized silybin nanocrystals. Int J Biol Macromol 124:667–680. https://doi.org/10.1016/j.ijbiomac.2018.11.25810.1016/j.ijbiomac.2018.11.258 ↗
41. Mekjaruskul C, Yang YT, Leed MG, Sadgrove MP, Jay M, Sripanidkulchai B (2013) Novel formulation strategies for enhancing oral delivery of methoxyflavones in kaempferia parviflora by smedds or complexation with 2-hydroxypropyl-beta-cyclodextrin. Int J Pharm 445(1–2):1–11. https://doi.org/10.1016/j.ijpharm.2013.01.05210.1016/j.ijpharm.2013.01.052 ↗
42. Menzel C, Holzeisen T, Laffleur F, Zaichik S, Abdulkarim M, Gumbleton M, Bernkop-Schnurch A (2018) In vivo evaluation of an oral self-emulsifying drug delivery system (sedds) for exenatide. J Control Release 277:165–172. https://doi.org/10.1016/j.jconrel.2018.03.01810.1016/j.jconrel.2018.03.018 ↗
43. Nekkanti V, Rueda J, Wang Z, Betageri GV (2016) Comparative evaluation of proliposomes and self micro-emulsifying drug delivery system for improved oral bioavailability of nisoldipine. Int J Pharm 505(1–2):79–88. https://doi.org/10.1016/j.ijpharm.2016.03.06510.1016/j.ijpharm.2016.03.065 ↗
44. Porter CJH, Trevaskis NL, Charman WN (2007) Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 3:231–24810.1038/nrd2197 ↗
45. Pouton CW (2000) Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and self-microemulsifying drug delivery systems. Eur J Pharm Sci NO.S2:S93–S9810.1016/S0928-0987(00)00167-6 ↗
46. Pouton CW, Porter CJH (2008) Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev 60(6):625–63710.1016/j.addr.2007.10.010 ↗
47. Qin Y, Nyheim H, Haram EM, Moritz JM, Hustvedt SO (2017) A novel self-micro-emulsifying delivery system (smeds) formulation significantly improves the fasting absorption of epa and dha from a single dose of an omega-3 ethyl ester concentrate. Lipids Health Dis 16(1):204. https://doi.org/10.1186/s12944-017-0589-010.1186/s12944-017-0589-0 ↗
48. Sangsen Y, Wiwattanawongsa K, Likhitwitayawuid K, Sritularak B, Graidist P, Wiwattanapatapee R (2016) Influence of surfactants in self-microemulsifying formulations on enhancing oral bioavailability of oxyresveratrol: studies in caco-2 cells and in vivo. Int J Pharm 498(1–2):294–303. https://doi.org/10.1016/j.ijpharm.2015.12.00210.1016/j.ijpharm.2015.12.002 ↗
49. Sato Y, Joumura T, Nashimoto S, Yokoyama S, Takekuma Y, Yoshida H, Sugawara M (2018) Enhancement of lymphatic transport of lutein by oral administration of a solid dispersion and a self-microemulsifying drug delivery system. Eur J Pharm Biopharm 127:171–176. https://doi.org/10.1016/j.ejpb.2018.02.01310.1016/j.ejpb.2018.02.013 ↗
50. Shanmugam S, Baskaran R, Balakrishnan P, Thapa P, Yong CS, Yoo BK (2011) Solid self-nanoemulsifying drug delivery system (s-snedds) containing phosphatidylcholine for enhanced bioavailability of highly lipophilic bioactive carotenoid lutein. Eur J Pharm Biopharm 79(2):250–257. https://doi.org/10.1016/j.ejpb.2011.04.01210.1016/j.ejpb.2011.04.012 ↗
51. Shete H, Sable S, Tidke P, Selkar N, Pawar Y, Chakraborty A, de A, Vanage G, Patravale V (2015) Mono-guanidine heterolipid based smedds: a promising tool for cytosolic delivery of antineoplastics. Biomaterials 57:116–132. https://doi.org/10.1016/j.biomaterials.2015.03.04010.1016/j.biomaterials.2015.03.040 ↗
52. Singh B, Bandopadhyay S, Kapil R, Singh R, Katare OP (2009) Self-emulsifying drug delivery systems (sedds): formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst 26(5):427–52110.1615/CritRevTherDrugCarrierSyst.v26.i5.10 ↗
53. Singh D, Tiwary AK, Bedi N (2018) Canagliflozin loaded smedds: formulation optimization for improved solubility, permeability and pharmacokinetic performance. J Pharm Investig 49:67–85. https://doi.org/10.1007/s40005-018-0385-510.1007/s40005-018-0385-5 ↗
54. Sun C, Gui Y, Hu R, Chen J, Wang B, Guo Y, Lu W, Nie X, Shen Q, Gao S, Fang W (2018) Preparation and pharmacokinetics evaluation of solid self-microemulsifying drug delivery system (s-smedds) of osthole. AAPS PharmSciTech 19(5):2301–2310. https://doi.org/10.1208/s12249-018-1067-310.1208/s12249-018-1067-3 ↗
55. Sunazuka Y, Ueda K, Higashi K, Tanaka Y, Moribe K (2018) Combined effects of the drug distribution and mucus diffusion properties of self-microemulsifying drug delivery systems on the oral absorption of fenofibrate. Int J Pharm 546(1–2):263–271. https://doi.org/10.1016/j.ijpharm.2018.05.03110.1016/j.ijpharm.2018.05.031 ↗
56. Tarr BD, Yalkowsky SH (1989) Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm Res 1:40–4310.1023/A:1015843517762 ↗
57. Tung NT, Tran CS, Pham TM, Nguyen HA, Nguyen TL, Chi SC, Nguyen DD, Bui TB (2018) Development of solidified self-microemulsifying drug delivery systems containing l-tetrahydropalmatine: design of experiment approach and bioavailability comparison. Int J Pharm 537(1–2):9–21. https://doi.org/10.1016/j.ijpharm.2017.12.02710.1016/j.ijpharm.2017.12.027 ↗
58. Vadlamudi HC, Yalavarthi PR, Nagaswaram T, Rasheed A, Peesa JP (2018) In-vitro and pharmacodynamic characterization of solidified self microemulsified system of quetiapine fumarate. J Pharm Investig 49(1):161–172. https://doi.org/10.1007/s40005-018-0397-110.1007/s40005-018-0397-1 ↗
59. Vohra AM, Patel CV, Kumar P, Thakkar HP (2017) Development of dual drug loaded solid self microemulsifying drug delivery system: exploring interfacial interactions using qbd coupled risk based approach. J Mol Liq 242:1156–1168. https://doi.org/10.1016/j.molliq.2017.08.00210.1016/j.molliq.2017.08.002 ↗
60. Wang L, Ma Y, Gu Y, Liu Y, Zhao J, Yan B, Wang Y (2018) Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. J Microencapsul 35(3):241–248. https://doi.org/10.1080/02652048.2018.146241610.1080/02652048.2018.1462416 ↗
61. Wu L, Qiao Y, Wang L, Guo J, Wang G, He W, Yin L, Zhao J (2015) A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against Depression: a Preparation and Bioavailability Study in Rat. AAPS Pharm Sci Tech 16(5):1051–1058. https://doi.org/10.1208/s12249-014-0280-y10.1208/s12249-014-0280-y ↗
62. Yadav P, Bandyopadhyay A, Chakraborty A, Sarkar K (2018) Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis. Carbohydr Polym 182:188–198. https://doi.org/10.1016/j.carbpol.2017.10.10210.1016/j.carbpol.2017.10.102 ↗
63. Yan B, Wang Y, Wang L, Zhou Y, Shang X, Zhao J et al (2018) Design and synthesis of a novel multifunctional stabilizer for highly stable dl-tetrahydropalmatine nanosuspensions and in vitro study. Appl Nanosci 8(6):1285–1297. https://doi.org/10.1007/s13204-018-0811-z10.1007/s13204-018-0811-z ↗
64. Yan B, Gu Y, Zhao J, Liu Y, Wang L, Wang Y (2019) Self-microemulsion technology for water insoluble drug delivery. Curr Nanosci 15. https://doi.org/10.2174/157341371566619011212210710.2174/1573413715666190112122107 ↗
65. Yang F, Zhou J, Hu X, Yu SK, Liu C, Pan R, Chang Q, Liu X, Liao Y (2017) Preparation and evaluation of self-microemulsions for improved bioavailability of ginsenoside-rh1 and rh2. Drug Deliv Transl Res 7(5):731–737. https://doi.org/10.1007/s13346-017-0402-710.1007/s13346-017-0402-7 ↗
66. Yeom DW, Son HY, Kim JH, Kim SR, Lee SG, Song SH, Chae BR, Choi YW (2016) Development of a solidified self-microemulsifying drug delivery system (s-smedds) for atorvastatin calcium with improved dissolution and bioavailability. Int J Pharm 506(1–2):302–311. https://doi.org/10.1016/j.ijpharm.2016.04.05910.1016/j.ijpharm.2016.04.059 ↗
67. Yi T, Wan J, Xu H, Yang X (2008) A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur J Pharm Biopharm 70(2):439–444. https://doi.org/10.1016/j.ejpb.2008.05.00110.1016/j.ejpb.2008.05.001 ↗
68. Zhao J, Liu Y, Wang L, Zhou Y, Du J, Wang Y (2018) Functional and modified nanocrystals technology for target drug delivery. J Nanosci Nanotechnol 18(8):5207–5221. https://doi.org/10.1166/jnn.2018.1542110.1166/jnn.2018.15421 ↗
69. Zhao J, Wang Y, Ma Y, Liu Y, Yan B, Wang L (2019) Smart nanocarrier based on pegylated hyaluronic acid for deacetyl mycoepoxydience: high stability with enhanced bioavailability and efficiency. Carbohydr Polym 203:356–368. https://doi.org/10.1016/j.carbpol.2018.09.07110.1016/j.carbpol.2018.09.071 ↗