Porous silicon nanoparticles as scavengers of hazardous viruses
Source abstract
Abstract
We report that silicon nanoparticles (SiN- Ps) with typical sizes from 5 to 50 nm prepared by grinding of porous silicon can act as efficient scavengers of human immunodeficiency virus (HIV) and respiratory syncytial virus (RSV). In vitro studies have revealed a strong suppression of the viral activity in the presence of SiNPs with concentration above 0.1 and 0.01 mg/mL for HIV and RSV, respectively. The observed effect is explained by binding of the virions with SiNPs that is supposed to be universal for different enveloped viruses. Because of the cytotoxic concentration of SiNPs is of the order of 1 mg/mL, SiNPs can be proposed for applications in new harmless methods of antiviral treatment.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Silicon Nanostructures and Photoluminescence · Nanowire Synthesis and Applications · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Adair BM (2009) Nanoparticle vaccines against respiratory viruses. WIREs Nanomed Nanobiotechnol 1:405–41410.1002/wnan.45 ↗
2. Anglin EJ, Cheng L, Freeman WR, Sailor MJ (2008) Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev 60:1266–127710.1016/j.addr.2008.03.017 ↗
3. Brandenburg AH, Neijens HJ, Osterhaus AD (2001) Pathogenesis of RSV lower respiratory tract infection: implications for vaccine development. Vaccine 19:2769–278210.1016/S0264-410X(00)00536-3 ↗
4. Canham LT (1990) Silicon quantum wire array fabrication by electrochemical and chemical dissolution of wafers. Appl Phys Lett 57:1046–104810.1063/1.103561 ↗
5. Canham LT (2007) Nanoscale semiconducting silicon as a nutritional food additive. Nanotechnology 18:1–610.1088/0957-4484/18/18/185704 ↗
6. Dowell SF, Anderson LJ, Gary HE, Erdman DD, Plouffe JF, File TM, Marston BJ, Breiman RF (1996) Respiratory syncytial virus is an important cause of community-acquired lower respiratory infection among hospitalized adults. J Infect Dis 174:456–46210.1093/infdis/174.3.456 ↗
7. Durnev AD, Solomina AS, Daugel-Dauge NO, Zhanataev AK, Shreder ED, Nemova EP, Shreder OV, Veligura VA, Osminkina LA, Timoshenko VY, Seredenin SB (2010) Evaluation of genotoxicity and reproductive toxicity of silicon nanocrystals. B Exp Biol Med 149:445–44910.1007/s10517-010-0967-3 ↗
8. Elechiguerra JL, Burt JL, Morones JR, Camacho-Bragado A, Gao X, Lara HH, Yacaman MJ (2005) Interaction of silver nanoparticles with HIV-1. J Nanobiotechnol 3(6):1–10
9. Federici G, Shaw BJ, Handy RD (2007) Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. Aquat Toxicol 84:415–43010.1016/j.aquatox.2007.07.009 ↗
10. Ferin J, Oberdorster G (1985) Biological effects and toxicity assessment of titanium dioxides: anatase and rutile. Am Ind Hyg Assoc J 46:69–7210.1080/15298668591394419 ↗
11. Föll H, Christophersen M, Carstensen J, Hasse G (2002) Formation and application of porous silicon. Mater Sci Eng R 39:93–14110.1016/S0927-796X(02)00090-6 ↗
12. Galdiero S, Falanga A, Vitiello M, Cantisani M, Marra V, Galdiero M (2011) Silver nanoparticles as potential antiviral agents. Molecules 16(10):8894–891810.3390/molecules16108894 ↗
13. Haggstrom J, Balyozova D, Klabunde KJ, Marchin G (2010) Virucidal properties of metal oxide nanoparticles and their halogen adducts. Nanoscale 2:234–529
14. Halfpenny KC, Wright DW (2010) Nanoparticle detection of respiratory infection. WIREs Nanomed Nanobiotechnol 2:277–29010.1002/wnan.83 ↗
15. Hamilton MA, Russo RC, Thurston RV (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11(7):714–71810.1021/es60130a004 ↗
16. Hong C, Lee J, Zheng H, Hong SS, Lee C (2011) Porous silicon nanoparticles for cancer photothermotherapy. Nanoscale Res Lett 6:32110.1186/1556-276X-6-321 ↗
17. Jafry HR, Liga MV, Li Q, Barron AR (2011) Simple route to enhanced photocatalytic activity of P25 titanium dioxide nanoparticles by silica addition. Environ Sci Technol 45:1563–156810.1021/es102749e ↗
18. Kabashin AV, Delaporte Ph, Pereira A, Grojo D, Torres R, Sarnet Th, Sentis M (2010) Nanofabrication with pulsed lasers. Nanosacle Res Lett 5:454–46310.1007/s11671-010-9543-z ↗
19. Kalem S, Yavuzcetin O (2000) Possibility of fabricating light-emitting porous silicon from gas phase etchants. Opt Express 6(1):7–1110.1364/OE.6.000007 ↗
20. Katsuhide F, Masanori H, Haruhisa K (2009) Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion. Toxicology Lett 191(23):109–117
21. Kim BY, Rutka JT, Chan WC (2010) Nanomedicine. N Engl J Med 363:2434–244310.1056/NEJMra0912273 ↗
22. Kovalainen M, Mönkäre J, Kaasalainen M, Riikonen J, Lehto VP, Salonen J, Herzig KH, Järvinen K (2013) Development of porous silicon nanocarriers for parenteral peptide delivery. Mol Pharm 10:353–35910.1021/mp300494p ↗
23. Kovalev D, Gross E, Künzner N, Koch F, Timoshenko VYu, Fujii M (2002) Resonant electronic energy transfer from excitons confined in silicon nanocrystals to oxygen molecules. Phys Rev Lett 89:13740110.1103/PhysRevLett.89.137401 ↗
24. Kumar A, Boruah BM, Liang XJ (2011) Gold Nanoparticles: promising nanomaterials for the diagnosis of cancer and HIV/AIDS. J Nanomater 10:1–17
25. Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C (2010) Mode of antiviral action of silver nanoparticles against HIV-1. J Nanobiotechnol 8(1):1–1010.1186/1477-3155-8-1 ↗
26. Lara HH, Ixtepan-Turrent L, Garza Treviño EN, Singh DK (2011) Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds. J Nanobiotechnol 9(38):1–9
27. Lewinski N, Colvin V, Drezek R (2008) Cytotoxicity of nanoparticles. Small 4(1):26–4910.1002/smll.200700595 ↗
28. Low SP, Voelcker NH, Canham LT, Williams KA (2009) The biocompatibility of porous silicon in tissues of the eye. Biomaterials 30:2873–288010.1016/j.biomaterials.2009.02.008 ↗
29. Low SP, Williams KA, Canham LT, Voelcker NH (2010) Generation of reactive oxygen species from porous silicon microparticles in cell culture medium. J Biomed Mat Res A 93A(3):1124–113110.1002/jbm.a.32610 ↗
30. Lozovski V, Tsykhonya A (2011) Electrodynamic interactions between a mesoparticle and a quantum dot. J Opt Soc Am B 28:365–37110.1364/JOSAB.28.000365 ↗
31. Osminkina LA, Gongalsky MB, Motuzuk AV, Timoshenko VY, Kudryavtsev AA (2011a) Silicon nanocrystals as photo- and sono-sensitizers for biomedical applications. Appl Phys B 105(3):665–66810.1007/s00340-011-4562-8 ↗
32. Osminkina LA, Luckyanova EN, Gongalsky MB, Kudryavtsev AA, Gaydarova AKh, Poltavtseva RA, Kashkarov PK, Timoshenko VYu, Sukhikh GT (2011b) Effects of nanostructurized silicon on proliferation of stem and cancer cell. Bull Exp Biol Med 151(1):79–8310.1007/s10517-011-1264-5 ↗
33. Osminkina LA, Tamarov KP, Sviridov AP, Galkin RA, Gongalsky MB, Solovyev VV, Kudryavtsev AA, Timoshenko VYu (2012) Photoluminescent biocompatible silicon nanoparticles for cancer theranostic applications. J Biophotonics 5(7):529–53510.1002/jbio.201100112 ↗
34. Park JH, Gu L, von Maltzahn G, Ruoslahti E, Bhatia SN, Sailor MJ (2009) Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nat Mater 8:331–33610.1038/nmat2398 ↗
35. Porstmann T, Kiessig ST (1997) Enzyme immunoassay techniques an overview. J Immunol Methods 150:5–2110.1016/0022-1759(92)90061-W ↗
36. Salonen J, Laitinen L, Kaukonen AM, Tuura J, Bjorkqvist M, Heikkila T, Vaha-Heikkila K, Hirvonen J, Lehto VP (2005) Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. J Controlled Release 108:362–37410.1016/j.jconrel.2005.08.017 ↗
37. Santos HA, Riikonen J, Salonen J, Makila E, Heikkilä T, Laaksonen T, Peltonen L, Lehto VP, Hirvonen J (2010) In vitro cytotoxicity of porous silicon microparticles: effect of the particle concentration, surface chemistry and size. Acta Biomater 6(7):2721–273110.1016/j.actbio.2009.12.043 ↗
38. Sekhon BS, Saluja V (2011) Nanovaccines-an overview. Int J Pharm Front Res 1(1):101–109
39. Shen F, Wang J, Xu Zh, Wu Y, Chen Q, Li X, Jie X, Li L, Yao M, Guo X, Zhu T (2012) Rapid flu diagnosis using silicon nanowire sensor. Nano Lett 12(7):3722–373010.1021/nl301516z ↗
40. Smith R, Collins S (1991) Porous silicon formation mechanisms. J Appl Phys 71:R1–R2210.1063/1.350839 ↗
41. Sun L, Singh AK, Vig K, Pillai SR, Singh SR (2008) Silver nanoparticles inhibit replication of respiratory syncytial virus. J Biomed Biotechnol 4:149–158
42. Sviridov AP, Andreev VG, Ivanova EM, Osminkina LA, Tamarov KP, Timoshenko VYu (2013) Porous silicon nanoparticles as sensitizers for ultrasonic hyperthermia. Appl Phys Lett 103:19311010.1063/1.4829148 ↗
43. Theiss W (1997) Optical properties of porous silicon. Surf Sci Rep 29:91–19210.1016/S0167-5729(96)00012-X ↗
44. Thompson WW, Shay DK, Weintraub E, Brammer L, Cox N, Anderson LJ, Fukuda K (2003) Mortality associated with influenza and respiratory syncytial virus in the United States. J Am Med Assoc 289(2):179–18610.1001/jama.289.2.179 ↗
45. Tijssen P (1985) Practice and theory of enzyme immunoassay. Elsevier, Amsterdam
46. Timoshenko VYu, Kudryavtsev AA, Osminkina LA, Vorontsov AS, Ryabchikov YuV, Belogorokhov IA, Kovalev D, Kashkarov PK (2006) Silicon nanocrystals as photosensitizers of active oxygen for biomedical applications. JETP Lett 83(9):423–42610.1134/S0021364006090128 ↗
47. UNAIDS (2012) UNAIDS World AIDS Day Report. http://www.unaids.org/en/
48. Xiao L, Gu L, Howell SB, Sailor MJ (2011) Porous silicon nanoparticle photosensitizers for singlet oxygen and their phototoxicity against cancer cells. ACS Nano 5(5):3651–365910.1021/nn1035262 ↗
49. Yu JC, Ho W, Lin J, Yip H, Wong PK (2003) Photocatalytic activity, antibacterial effect, and photoinduced hydrophilicity of TiO2 films coated on a stainless steel substrate. Environ Sci Technol 37:2296–230110.1021/es0259483 ↗
50. Zhu RR, Wang SL (2009) Bio-effects of nano-TiO2 on DNA and cellular ultrastructure with different polymorph and size. Mater Sci Eng C 29(3):691–69610.1016/j.msec.2008.12.023 ↗