Distinguishing nanomaterial particles from background airborne particulate matter for quantitative exposure assessment
Source abstract
Abstract
As the production of engineered nanomaterials quantitatively expands, the chance that workers involved in the manufacturing process will be exposed to nanoparticles also increases. A risk management system is needed for workplaces in the nanomaterial industry based on the precautionary principle. One of the problems in the risk management system is difficulty of exposure assessment. In this article, examples of exposure assessment in nanomaterial industries are reviewed with a focus on distinguishing engineered nanomaterial particles from background nanoparticles in workplace atmosphere. An approach by JNIOSH (Japan National Institute of Occupational Safety and Health) to quantitatively measure exposure to carbonaceous nanomaterials is also introduced. In addition to real-time measurements and qualitative analysis by electron microscopy, quantitative chemical analysis is necessary for quantitatively assessing exposure to nanomaterials. Chemical analysis is suitable for quantitative exposure measurement especially at facilities with high levels of background NPs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Air Quality and Health Impacts · Recycling and Waste Management Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. Baron PA, Deye GJ, Chen BT et al (2008) Aerosolization of single-walled carbon nanotubes for an inhalation study. Inhal Toxicol 20:751–76010.1080/08958370801975303 ↗
2. Birch ME, Cary RA (1996) Elemental carbon-based method for monitoring occupational exposures to particulate diesel exhaust. Aerosol Sci Technol 25:221–24110.1080/02786829608965393 ↗
3. British Standard Institute (2008a) Nanotechnologies – Part 1: Good practice guide for specifying manufactured nanomaterials. PD 6699-1:2007
4. British Standard Institute (2008b) Nanotechnologies – Part 2: Guide to safe handling and disposal of manufactured nanomaterials PD 6699-2:2007
5. Brouwer D, Gijsbers J, Lurvink MWM (2004) Personal exposure to UFP in the workplace: exploring sampling techniques and strategies. Ann Occp Hyg 48:436–453
6. Bundesanstalt für Albeitsshutz und Albeitsmedizin (Federal Institute for Occupational Safety and Health) (2008) Exposure to nanomaterials in Germany: Results of the corporate survey of the Federal Institute for Occupational Health and Safety (BAuA) and the Association of the Chemical Industry (VCI) using questionnaires
7. Chow JC, Watson JG, Pritchett LC et al (1993) The DRI thermal/optical reflectance carbon analysis system. Atmos Environ 27A:1185–120110.1016/0960-1686(93)90245-T ↗
8. Dasch J, D’Arcy J (2008) Physical and chemical characterization of airborne particles from welding operations in automotive plants. J Occup Environ Hyg 5:444–45410.1080/15459620802122720 ↗
9. Demou E, Peter P, Hellweg S (2008) Exposure to manufactured nanostructured particles in an industrial pilot plant. Ann Occup Hyg 52:695–706. doi: 10.1093/annhyg/men058
10. Donaldson K, Li XY, MacNee W (1998) Ultrafine (nanometre) particle mediated lung injury. J Aerosol Sci 29:553–56010.1016/S0021-8502(97)00464-3 ↗
11. Evans DE, Heitbrink WA, Slavin TJ et al (2008) Ultrafine and respirable particles in an automotive grey iron foundry. Ann Occup Hyg 52:9–2110.1093/annhyg/mem056 ↗
12. Fujitani Y, Kobayashi T, Arashidani K et al (2008) Measurement of the physical properties of aerosols in a fullerene factory for inhalation exposure assessment. J Occup Environ Hyg 5:380–38910.1080/15459620802050053 ↗
13. Grassian VH, O’shaughnessy PT, Adamcakova-Dodd A et al (2007) Inhalation exposure study of titanium dioxide nano-particles with a primary particle size of 2 to 5 nm. Environ Health Perspect 115:397–40210.1289/ehp.9469 ↗
14. Han JH, Lee EJ, Lee JH et al (2008) Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 20:741–74910.1080/08958370801942238 ↗
15. Hansen ADA, Rosen H, Novakov T (1984) The aethalometer—an instrument for the real-time measurement of optical absorption by aerosol particles. Sci Total Environ 36:191–19610.1016/0048-9697(84)90265-1 ↗
16. Health and Safety Executive (2006) The assessment of different metrics of the concentration of nano (ultrafine) particles in existing and new industries. Research Report 513
17. Heitbrink WA, Evans DE, Peters TM et al (2007) Characterization and mapping of very fine particles in an engine machining and assembly facility. J Occup Environ Hyg 4:341–35110.1080/15459620701290081 ↗
18. Heitbrink WA, Evans DE, Ku BK et al (2009) Relationships among particle number, surface area, and respirable mass concentrations in automotive engine manufacturing. J Occup Environ Hyg 6:19–3110.1080/15459620802530096 ↗
19. Heymann D, Chibante LPF, Smally RE (1995) Determination of C60 and C70 fullerenes in geologic materials by high-performance liquid chromatography. J Chromatogr A 689:157–16310.1016/0021-9673(94)00941-2 ↗
20. Institut de recherché Robert-Sauvé en santé et en sécurité du travial (2009) Best practice guide to synthetic nanoparticle risk management. Report R599
21. International Standard Organization (2008) ISO/TR 12885:2008 nanotechnologies-health and safety, particles in occupational settings relevant to nanotechnologies
22. Japan National Institute of Occupational Safety and Health, Field Report Summery 1. Present status of workplace air in a fullerene processing clean-room, and evaluation of performances of particle measurement devices and HPLC analysis. http://www.jniosh.go.jp/joho/nano/files/jniosh/report_fullerene_081028.pdf
23. Ku BK, Maynard AD (2005) Comparing aerosol surface-area measurements of monodisperse ultrafine silver agglomerates by mobility analysis, transmission electron microscopy and diffusion charging. J Aerosol Sci 36:1108–112410.1016/j.jaerosci.2004.12.003 ↗
24. Kuhlbusch TA, Fissan H (2006) Particle characteristics in the reactor and pelletizing areas of carbon black production. J Occup Environ Hyg 3:558–56710.1080/15459620600912280 ↗
25. Kuhlbusch TA, Neumann S, Fissan H (2004) Number size distribution, mass concentration, and particle composition of PM1, PM2.5, and PM10 in bag filling areas of carbon black production. J Occup Environ Hyg 1:660–67110.1080/15459620490502242 ↗
26. Lam CW, James J J, McCluskey R et al (2004) Pulmonary toxicity of single-wall CNT in Mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126–13410.1093/toxsci/kfg243 ↗
27. Maynard AD, Aitken RJ (2007) Assessing exposure to airborne nanomaterials: current abilities and future requirements. Nanotoxicology 1:26–4110.1080/17435390701314720 ↗
28. Maynard AD, Baron P (2004) Exposure to CNT Material: aerosol release during the handling of unrefined single-walled CNT material. J Toxicol Environ Health 67:87–10710.1080/15287390490253688 ↗
29. McCawley MA, Kent MS, Berakis MT (2001) Ultrafine beryllium number concentration as a possible metric for chronic beryllium disease risk. Appl Occup Environ Hyg 16:631–63810.1080/10473220120812 ↗
30. Methner MM, Birch ME, Evans DE et al (2007) Identification and characterization of potential sources of worker exposure to carbon nanofibers during polymer composite laboratory operations. J Occup Environ Hyg 4:D125–D13010.1080/15459620701683871 ↗
31. Misra C, Singh M, Shen S, Sioutas C et al (2002) Development and evaluation of a personal cascade impactor sampler (PCIS). J Aerosol Sci 33:1027–104710.1016/S0021-8502(02)00055-1 ↗
32. Myojo T, Oyabu T, Nishi K et al (2008) Aerosol generation and measurement of multi-wall carbon nanotubes. J Nanoparticle Res 11:91–9910.1007/s11051-008-9450-8 ↗
33. National Institute for Occupational Safety and Health (2008) Approaches to safe nanotechnology: an information exchange with NIOSH. http://www.cdc.gov/niosh/topics/nanotech/safenano/
34. National Institute for Occupational Safety and Health (NIOSH) (1994) In: Schlecht PC, O’Connor PF (eds) Method 5040. NIOSH manual of analytical methods (NMAM), 4th ed. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, Cincinnati, Ohio—DHHS (NIOSH) Pub. 94-113
35. Oberdörster G (2001) Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health 74:1–810.1007/s004200000185 ↗
36. Obersdörster G (1996) Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhales particles. Inhal Toxicol 8(supl):73–89
37. Paik SY, Zalk DM, Swuste P (2008) Application of a pilot control banding tool for risk level assessment and control of nano-particle exposures. Ann Occup Hyg 52:419–428. doi: 10.1093/annhyg/men041
38. Peters TM, Heitbrink WA, Evans DE et al (2006) The mapping of fine and ultrafine particle concentrations in an engine machining and assembly facility. Ann Occup Hyg 50:249–257
39. Peters TM, Elzey S, Johnson R et al (2009) Airborne monitoring to distinguish engineered nanomaterials from incidental particles for environmental health and safety. J Occup Environ Hyg 6:73–8110.1080/15459620802590058 ↗
40. Petzpd A, Niessner R (1996) Coulometrische Messung der Russbelastung in der Aussenluft-Verfahrensentwicklung und Anwendung an Messstellen unterschiedlicher Belastung. Gefahrstoffe- Reinhaltung der Luft 56
41. Poland CA, Duffin R, Kinloch I et al (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423–42810.1038/nnano.2008.111 ↗
42. Schulte P, Geraci C, Zumwalde R et al (2008) Occupational risk management of engineered nano-particles. J Occup Environ Hyg 5:239–24910.1080/15459620801907840 ↗
43. Shin WG, Pui DYH, Fissan H et al (2007) Calibration and numerical simulation of nanoparticle surface area monitor (TSI Mpdel 3550 NSAM). J Nanoparticle Res 9:61–6910.1007/s11051-006-9153-y ↗
44. Shvedova AA, Kisin ER, Mercer R et al (2005) Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–L70810.1152/ajplung.00084.2005 ↗
45. Shvedova AA, Fabisiak JP, Kisin ER et al (2008a) Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am J Respir Cell Mol Biol 38:579–59010.1165/rcmb.2007-0255OC ↗
46. Shvedova AA, Kisin ER, Murray AR et al (2008b) Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 295:L552–L56510.1152/ajplung.90287.2008 ↗
47. Takagi A, Hirose A, Nishimura T et al (2008) Induction of mesothelioma in p53± mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 33:105–11610.2131/jts.33.105 ↗
48. Thomassen Y, Koch W, Dunkhorst W et al (2006) Ultrafine particles at workplaces of a primary aluminium smelter. J Environ Monit 8:127–13310.1039/B514939H ↗
49. Warheit DB, Laurence BR, Reed KL et al (2004) Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77:117–12510.1093/toxsci/kfg228 ↗
50. Xia XR, Monteiro-Riviere NA, Riviere JE (2006) Trace analysis of fullerenes in biological samples by simplified liquid–liquid extraction and high-performance liquid chromatography. J Chromatogr A 1129:216–22210.1016/j.chroma.2006.07.030 ↗
51. Zimmer AT (2002) The influence of metallurgy on the formation of welding aerosols. J Environ Monit 4:628–63210.1039/B202337G ↗
52. Zimmer AT, Biswas P (2001) Characterization of the aerosols resulting from arc welding processes. J Aerosol Sci 32:993–100810.1016/S0021-8502(01)00035-0 ↗