Fabrication of highly fluorescent multiple Fe3O4 nanoparticles core-silica shell nanoparticles
Source abstract
Abstract
The synthesis of hybrid nanoparticles with multiple functions from the economical and scalable perspective is an important issue in nanoparticle engineering. Herein, we report a representative example of multi-functional nanosystems simultaneously possessing fluorescence and magnetism as well as the excellent structural properties of nanosilica. Highly fluorescent multiple Fe3O4 nanoparticles core-silica shell nanoparticles (FL multi-Fe3O4@SiO2 NPs) are successfully synthesized and fully characterized. The multiple Fe3O4 nanoparticles can be uniformly and collectively encapsulated within a silica matrix using a reverse microemulsion (RM) method. Fluorescent dyes are successfully functionalized through the sequential hydrolysis and condensation of tetraethylorthosilicate (TEOS) and 3-(aminopropyl) triethoxysilane (APTES). Both organic (fluorescein) and inorganic (Rubpy) dyes can be used to generate the FL multi-Fe3O4@SiO2 NPs. These synthetic paradigms for multi-functional nanoparticles can significantly facilitate the fabrications of unique nanomaterials widely applied in a variety of areas.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanomaterials for catalytic reactions · Iron oxide chemistry and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (93)
Show source-provided references
1. Alberto G, Caputo G, Viscardi G, Coluccia S, Martra G (2012) Molecular engineering of hybrid dye–silica fluorescent nanoparticles: influence of the dye structure on the distribution of fluorophores and consequent photoemission brightness. Chem Mater 24:2792–2801. https://doi.org/10.1021/cm301308g10.1021/cm301308g ↗
2. Bagwe RP, Yang C, Hilliard LR, Tan W (2004) Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir 20:8336–8342. https://doi.org/10.1021/la049137j10.1021/la049137j ↗
3. Bartelmess J, Quinn SJ, Giordani S (2015) Carbon nanomaterials: multi-functional agents for biomedical fluorescence and Raman imaging. Chem Soc Rev 44:4672–4698. https://doi.org/10.1039/C4CS00306C10.1039/C4CS00306C ↗
4. Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol 33:941–951. https://doi.org/10.1038/nbt.333010.1038/nbt.3330 ↗
5. Blum AP, Kammeyer JK, Rush AM, Callmann CE, Hahn ME, Gianneschi NC (2015) Stimuli-responsive nanomaterials for biomedical applications. J Am Chem Soc 137:2140–2154. https://doi.org/10.1021/ja510147n10.1021/ja510147n ↗
6. Byoun W, Yoo H (2017) Peapod assemblies of Au and Au/Pt nanoparticles encapsulated within hollow silica nanotubes. ChemistrySelect 2:2414–2419. https://doi.org/10.1002/slct.20170037910.1002/slct.201700379 ↗
7. Byoun W, Jung S, Tran NM, Yoo H (2018) Synthesis and application of dendritic fibrous nanosilica/gold hybrid nanomaterials. ChemistryOpen 7:349–355. https://doi.org/10.1002/open.20180004010.1002/open.201800040 ↗
8. Cha J, Cui P, Lee J-K (2010) A simple method to synthesize multifunctional silica nanocomposites, NPs@SiO2, using polyvinylpyrrolidone (PVP) as a mediator. J Mater Chem 20:5533–5537. https://doi.org/10.1039/B924702E10.1039/B924702E ↗
9. Chatterjee K, Sarkar S, Jagajjanani Rao K, Paria S (2014) Core/shell nanoparticles in biomedical applications. Adv Colloid Interf Sci 209:8–39. https://doi.org/10.1016/j.cis.2013.12.00810.1016/j.cis.2013.12.008 ↗
10. Chen Y, Chen H-R, Shi J-L (2014) Construction of homogenous/heterogeneous hollow mesoporous silica nanostructures by silica-etching chemistry: principles, synthesis, and applications. Acc Chem Res 47:125–137. https://doi.org/10.1021/ar400091e10.1021/ar400091e ↗
11. Chen Y, Fan Z, Zhang Z, Niu W, Li C, Yang N, Chen B, Zhang H (2018) Two-dimensional metal nanomaterials: synthesis, properties, and applications. Chem Rev 118:6409–6455. https://doi.org/10.1021/acs.chemrev.7b0072710.1021/acs.chemrev.7b00727 ↗
12. Cheng L, Wang C, Feng L, Yang K, Liu Z (2014) Functional nanomaterials for phototherapies of cancer. Chem Rev 114:10869–10939. https://doi.org/10.1021/cr400532z10.1021/cr400532z ↗
13. Chowdhuri AR, Singh T, Ghosh SK, Sahu SK (2016) Carbon dots embedded magnetic nanoparticles @chitosan@metal organic framework as a nanoprobe for pH sensitive targeted anticancer drug delivery. ACS Appl Mater Interfaces 8:16573–16583. https://doi.org/10.1021/acsami.6b0398810.1021/acsami.6b03988 ↗
14. Collins G, Schmidt M, McGlacken GP, O’Dwyer C, Holmes JD (2014) Stability, oxidation, and shape evolution of PVP-capped Pd nanocrystals. J Phys Chem C 118:6522–6530. https://doi.org/10.1021/jp500716z10.1021/jp500716z ↗
15. Corr SA, Byrne SJ, Tekoriute R, Meledandri CJ, Brougham DF, Lynch M, Kerskens C, O'Dwyer L, Gun'ko YK (2008) Linear assemblies of magnetic nanoparticles as MRI contrast agents. J Am Chem Soc 130:4214–4215. https://doi.org/10.1021/ja710172z10.1021/ja710172z ↗
16. Dai Q, Berman D, Virwani K, Frommer J, Jubert P-O, Lam M, Topuria T, Imaino W, Nelson A (2010) Self-assembled ferrimagnet−polymer composites for magnetic recording media. Nano Lett 10:3216–3221. https://doi.org/10.1021/nl102274910.1021/nl1022749 ↗
17. De Crozals G, Bonnet R, Farre C, Chaix C (2016) Nanoparticles with multiple properties for biomedical applications: a strategic guide. Nano Today 11:435–463. https://doi.org/10.1016/j.nantod.2016.07.00210.1016/j.nantod.2016.07.002 ↗
18. Ding HL, Zhang YX, Wang S, Xu JM, Xu SC, Li GH (2012) Fe3O4@SiO2 core/shell nanoparticles: the silica coating regulations with a single core for different core sizes and shell thicknesses. Chem Mater 24:4572–4580. https://doi.org/10.1021/cm302828d10.1021/cm302828d ↗
19. Fratila RM, Rivera-Fernández S, de la Fuente JM (2015) Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials. Nanoscale 7:8233–8260. https://doi.org/10.1039/C5NR01100K10.1039/C5NR01100K ↗
20. Gawande MB, Goswami A, Asefa T, Guo H, Biradar AV, Peng D-L, Zboril R, Varma RS (2015) Core–shell nanoparticles: synthesis and applications in catalysis and electrocatalysis. Chem Soc Rev 44:7540–7590. https://doi.org/10.1039/C5CS00343A10.1039/C5CS00343A ↗
21. Ghosh Chaudhuri R, Paria S (2012) Core/shell nanoparticles: classes, properties, synthesis mechanisms, characterization, and applications. Chem Rev 112:2373–2433. https://doi.org/10.1021/cr100449n10.1021/cr100449n ↗
22. Guo X, Mao F, Wang W, Yang Y, Bai Z (2015) Sulfhydryl-modified Fe3O4@SiO2 core/shell nanocomposite: synthesis and toxicity assessment in vitro. ACS Appl Mater Interfaces 7:14983–14991. https://doi.org/10.1021/acsami.5b0387310.1021/acsami.5b03873 ↗
23. Han R, Li W, Pan W, Zhu M, Zhou D, Li F-s (2014) 1D magnetic materials of Fe3O4 and Fe with high performance of microwave absorption fabricated by electrospinning method. Sci Rep 4:7493. https://doi.org/10.1038/srep0749310.1038/srep07493 ↗
24. Hanafi-Bojd MY, Jaafari MR, Ramezanian N, Xue M, Amin M, Shahtahmassebi N, Malaekeh-Nikouei B (2015) Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells. Eur J Pharm Biopharm 89:248–258. https://doi.org/10.1016/j.ejpb.2014.12.00910.1016/j.ejpb.2014.12.009 ↗
25. He X, Chen J, Wang K, Qin D, Tan W (2007) Preparation of luminescent Cy5 doped core-shell SFNPs and its application as a near-infrared fluorescent marker. Talanta 72:1519–1526. https://doi.org/10.1016/j.talanta.2007.01.06910.1016/j.talanta.2007.01.069 ↗
26. Hong L-R, Chai Y-Q, Zhao M, Liao N, Yuan R, Zhuo Y (2015) Highly efficient electrogenerated chemiluminescence quenching of PEI enhanced Ru(bpy)32+ nanocomposite by hemin and Au@CeO2 nanoparticles. Biosens Bioelectron 63:392–398. https://doi.org/10.1016/j.bios.2014.07.06510.1016/j.bios.2014.07.065 ↗
27. Hu Y, Wang R, Wang S, Ding L, Li J, Luo Y, Wang X, Shen M, Shi X (2016) Multifunctional Fe3O4@Au core/shell nanostars: a unique platform for multimode imaging and photothermal therapy of tumors. Sci Rep 6:28325. https://doi.org/10.1038/srep2832510.1038/srep28325 ↗
28. Jang MH, Pak J, Yoo H (2013) Synthesis of highly emissive PIPES-stabilized gold nanoclusters and gold nanocluster-doped silica nanoparticles. J Nanosci Nanotechnol 13:2922–2928. https://doi.org/10.1166/jnn.2013.736510.1166/jnn.2013.7365 ↗
29. Jia Z, Xiu P, Xiong P, Zhou W, Cheng Y, Wei S, Zheng Y, Xi T, Cai H, Liu Z, Wang C, Zhang W, Li Z (2016) Additively manufactured macroporous titanium with silver-releasing micro−/nanoporous surface for multipurpose infection control and bone repair—a proof of concept. ACS Appl Mater Interfaces 8:28495–28510. https://doi.org/10.1021/acsami.6b1047310.1021/acsami.6b10473 ↗
30. Jiang H, Liu Y, Luo W, Wang Y, Tang X, Dou W, Cui Y, Liu W (2018) A resumable two-photon fluorescent probe for Cu2+ and S2− based on magnetic silica core-shell Fe3O4@SiO2 nanoparticles and its application in bioimaging. Anal Chim Acta 1014:91–99. https://doi.org/10.1016/j.aca.2018.02.00610.1016/j.aca.2018.02.006 ↗
31. Jin H, Guo C, Liu X, Liu J, Vasileff A, Jiao Y, Zheng Y, Qiao S-Z (2018) Emerging two-dimensional nanomaterials for electrocatalysis. Chem Rev 118:6337–6408. https://doi.org/10.1021/acs.chemrev.7b0068910.1021/acs.chemrev.7b00689 ↗
32. Kharisov BI, Dias HVR, Kharissova OV, Vázquez A, Peña Y, Gómez I (2014) Solubilization, dispersion and stabilization of magnetic nanoparticles in water and non-aqueous solvents: recent trends. RSC Adv 4:45354–45381. https://doi.org/10.1039/C4RA06902A10.1039/C4RA06902A ↗
33. Kim J, Kim HS, Lee N et al (2008) Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew Chem Int Ed 47:8438–8441. https://doi.org/10.1002/anie.20080246910.1002/anie.200802469 ↗
34. Kim JW, Kim LU, Kim CK (2007) Size control of silica nanoparticles and their surface treatment for fabrication of dental nanocomposites. Biomacromolecules 8:215–222. https://doi.org/10.1021/bm060560b10.1021/bm060560b ↗
35. Koczkur KM, Mourdikoudis S, Polavarapu L, Skrabalak SE (2015) Polyvinylpyrrolidone (PVP) in nanoparticle synthesis. Dalton Trans 44:17883–17905. https://doi.org/10.1039/C5DT02964C10.1039/C5DT02964C ↗
36. Kostyukova D, Yoo H (2016) Facile fabrication of platinum nanodots assembly core–silica shell nanosystems. J Electron Mater 45:2361–2371. https://doi.org/10.1007/s11664-015-4313-410.1007/s11664-015-4313-4 ↗
37. Lai L, Xie Q, Chi L, Gu W, Wu D (2016) Adsorption of phosphate from water by easily separable Fe3O4@SiO2 core/shell magnetic nanoparticles functionalized with hydrous lanthanum oxide. J Colloid Interface Sci 465:76–82. https://doi.org/10.1016/j.jcis.2015.11.04310.1016/j.jcis.2015.11.043 ↗
38. Lakowicz JR (2006) Principles of fluorescence spectroscopy, 3rd Ed. Springer.10.1007/978-0-387-46312-4 ↗
39. Lee J, Lee Y, Youn JK, Na HB, Yu T, Kim H, Lee SM, Koo YM, Kwak JH, Park HG, Chang HN, Hwang M, Park JG, Kim J, Hyeon T (2008) Simple synthesis of functionalized superparamagnetic magnetite/silica core/shell nanoparticles and their application as magnetically separable high-performance biocatalysts. Small 4:143–152. https://doi.org/10.1002/smll.20070045610.1002/smll.200700456 ↗
40. Lee JE, Lee N, Kim H, Kim J, Choi SH, Kim JH, Kim T, Song IC, Park SP, Moon WK, Hyeon T (2010) Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery. J Am Chem Soc 132:552–557. https://doi.org/10.1021/ja905793q10.1021/ja905793q ↗
41. Lee N, Hyeon T (2012) Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents. Chem Soc Rev 41:2575–2589. https://doi.org/10.1039/C1CS15248C10.1039/C1CS15248C ↗
42. Lee N, Yoo D, Ling D, Cho MH, Hyeon T, Cheon J (2015) Iron oxide based nanoparticles for multimodal imaging and magnetoresponsive therapy. Chem Rev 115:10637–10689. https://doi.org/10.1021/acs.chemrev.5b0011210.1021/acs.chemrev.5b00112 ↗
43. Lei J, Wang L, Zhang J (2011) Superbright multifluorescent core−shell mesoporous nanospheres as trackable transport carrier for drug. ACS Nano 5:3447–3455. https://doi.org/10.1021/nn103254g10.1021/nn103254g ↗
44. Li F, Yu Y, Li Q, Zhou M, Cui H (2014b) A homogeneous signal-on strategy for the detection of rpoB genes of mycobacterium tuberculosis based on electrochemiluminescent graphene oxide and ferrocene quenching. Anal Chem 86:1608–1613. https://doi.org/10.1021/ac403281g10.1021/ac403281g ↗
45. Li W-P, Liao P-Y, Su C-H, Yeh C-S (2014a) Formation of oligonucleotide-gated silica shell-coated Fe3O4-Au core–shell nanotrisoctahedra for magnetically targeted and near-infrared light-responsive theranostic platform. J Am Chem Soc 136:10062–10075. https://doi.org/10.1021/ja504118q10.1021/ja504118q ↗
46. Liberman A, Mendez N, Trogler WC, Kummel AC (2014) Synthesis and surface functionalization of silica nanoparticles for nanomedicine. Surf Sci Rep 69:132–158. https://doi.org/10.1016/j.surfrep.2014.07.00110.1016/j.surfrep.2014.07.001 ↗
47. Lim WQ, Phua SZF, Xu HV, Sreejith S, Zhao Y (2016) Recent advances in multifunctional silica-based hybrid nanocarriers for bioimaging and cancer therapy. Nanoscale 8:12510–12519. https://doi.org/10.1039/C5NR07853A10.1039/C5NR07853A ↗
48. Lin L-S, Cong Z-X, Cao J-B, Ke K-M, Peng Q-L, Gao J, Yang H-H, Liu G, Chen X (2014) Multifunctional Fe3O4@polydopamine core–shell nanocomposites for intracellular mRNA detection and imaging-guided photothermal therapy. ACS Nano 8:3876–3883. https://doi.org/10.1021/nn500722y10.1021/nn500722y ↗
49. Ling D, Lee N, Hyeon T (2015) Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. Acc Chem Res 48:1276–1285. https://doi.org/10.1021/acs.accounts.5b0003810.1021/acs.accounts.5b00038 ↗
50. Liu C, Yu H, Li Q, Zhu C, Xia Y (2018) Brighter, more stable, and less toxic: a host–guest interaction-aided strategy for fabricating fluorescent silica nanoparticles and applying them in bioimaging and biosensing at the cellular level. ACS Appl Mater Interfaces 10:16291–16298. https://doi.org/10.1021/acsami.8b0303410.1021/acsami.8b03034 ↗
51. Lu A-H, Salabas EL, Schüth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed 46:1222–1244. https://doi.org/10.1002/anie.20060286610.1002/anie.200602866 ↗
52. Mai HD, Seo K, Choi S, Yoo H (2015) High catalytic performance of raspberry-like gold nanoparticles and enhancement of stability by silica coating. RSC Adv 5:18977–18982. https://doi.org/10.1039/C5RA00650C10.1039/C5RA00650C ↗
53. Malyutin AG, Easterday R, Lozovyy Y, Spilotros A, Cheng H, Sanchez-Felix OR, Stein BD, Morgan DG, Svergun DI, Dragnea B, Bronstein LM (2015) Viruslike nanoparticles with maghemite cores allow for enhanced MRI contrast agents. Chem Mater 27:327–335. https://doi.org/10.1021/cm504029j10.1021/cm504029j ↗
54. Manju S, Sreenivasan K (2011) Enhanced drug loading on magnetic nanoparticles by layer-by-layer assembly using drug conjugates: blood compatibility evaluation and targeted drug delivery in cancer cells. Langmuir 27:14489–14496. https://doi.org/10.1021/la202470k10.1021/la202470k ↗
55. Meffre A, Mehdaoui B, Connord V, Carrey J, Fazzini PF, Lachaize S, Respaud M, Chaudret B (2015) Complex nano-objects displaying both magnetic and catalytic properties: a proof of concept for magnetically induced heterogeneous catalysis. Nano Lett 15:3241–3248. https://doi.org/10.1021/acs.nanolett.5b0044610.1021/acs.nanolett.5b00446 ↗
56. Nasir Baig RB, Varma RS (2014) Magnetic carbon-supported palladium nanoparticles: an efficient and sustainable catalyst for hydrogenation reactions. ACS Sustain Chem Eng 2:2155–2158. https://doi.org/10.1021/sc500341h10.1021/sc500341h ↗
57. Nyffenegger R, Quellet C, Ricka J (1993) Synthesis of fluorescent, monodisperse, colloidal silica particles. J Colloid Interface Sci 159:150–157. https://doi.org/10.1006/jcis.1993.130610.1006/jcis.1993.1306 ↗
58. Oh S-D, Kim M-R, Choi S-H, Chun JH, Lee KP, Gopalan A, Hwang C-G, Sang-Ho K, Hoon OJ (2008) Radiolytic synthesis of Pd–M (M=Ag, Au, Cu, Ni and Pt) alloy nanoparticles and their use in reduction of 4-nitrophenol. J Ind Eng Chem 14:687–692. https://doi.org/10.1016/j.jiec.2008.04.00810.1016/j.jiec.2008.04.008 ↗
59. Pak J, Yoo H (2013) Facile synthesis of spherical nanoparticles with a silica shell and multiple Au nanodots as the core. J Mater Chem A 1:5408–5413. https://doi.org/10.1039/C3TA10613F10.1039/C3TA10613F ↗
60. Pak J, Yoo H (2014) Synthesis and catalytic performance of multiple gold nanodots core–mesoporous silica shell nanoparticles. Microporous Mesoporous Mater 185:107–112. https://doi.org/10.1016/j.micromeso.2013.11.00310.1016/j.micromeso.2013.11.003 ↗
61. Qu H, Caruntu D, Liu H, O’Connor CJ (2011) Water-dispersible iron oxide magnetic nanoparticles with versatile surface functionalities. Langmuir 27:2271–2278. https://doi.org/10.1021/la104471r10.1021/la104471r ↗
62. Quinto CA, Mohindra P, Tong S, Bao G (2015) Multifunctional superparamagnetic iron oxide nanoparticles for combined chemotherapy and hyperthermia cancer treatment. Nanoscale 7:12728–12736. https://doi.org/10.1039/C5NR02718G10.1039/C5NR02718G ↗
63. Revia RA, Zhang M (2016) Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances. Mater Today 19:157–168. https://doi.org/10.1016/j.mattod.2015.08.02210.1016/j.mattod.2015.08.022 ↗
64. Santra S, Wang K, Tapec R, Tan W (2001a) Development of novel dye-doped silica nanoparticles for biomarker application. J Biomed Opt 6:160–166. https://doi.org/10.1117/1.135359010.1117/1.1353590 ↗
65. Santra S, Zhang P, Wang K, Tapec R, Tan W (2001b) Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem 73:4988–4993. https://doi.org/10.1021/ac010406+10.1021/ac010406+ ↗
66. Santra S, Bagwe RP, Dutta D, Stanley JT, Walter GA, Tan W, Moudgil BM, Mericle RA (2005) Synthesis and characterization of fluorescent, radio-opaque, and paramagnetic silica nanoparticles for multimodal bioimaging applications. Adv Mater 17:2165–2169. https://doi.org/10.1002/adma.20050001810.1002/adma.200500018 ↗
67. Shen L, Laibinis PE, Hatton TA (1999) Bilayer surfactant stabilized magnetic fluids: synthesis and interactions at interfaces. Langmuir 15:447–453. https://doi.org/10.1021/la980766110.1021/la9807661 ↗
68. Stöber W, Fink A, Bohn E (1968) Controlled growth of monodisperse silica spheres in the micron size range. J Colloid Interface Sci 26:62–69. https://doi.org/10.1016/0021-9797(68)90272-510.1016/0021-9797(68)90272-5 ↗
69. Tan C, Cao X, Wu X-J, He Q, Yang J, Zhang X, Chen J, Zhao W, Han S, Nam G-H, Sindoro M, Zhang H (2017) Recent advances in ultrathin two-dimensional nanomaterials. Chem Rev 117:6225–6331. https://doi.org/10.1021/acs.chemrev.6b0055810.1021/acs.chemrev.6b00558 ↗
70. Tang X, Zhao D, He J, Li F, Peng J, Zhang M (2013) Quenching of the electrochemiluminescence of tris(2,2′-bipyridine)ruthenium(II)/tri-n-propylamine by pristine carbon nanotube and its application to quantitative detection of DNA. Anal Chem 85:1711–1718. https://doi.org/10.1021/ac303025y10.1021/ac303025y ↗
71. Tapec R, Zhao XJ, Tan W (2002) Development of organic dye-doped silica nanoparticles for bioanalysis and biosensors. J Nanosci Nanotechnol 2:405–409. https://doi.org/10.1166/jnn.2002.11410.1166/jnn.2002.114 ↗
72. Tarn D, Ashley CE, Xue M, Carnes EC, Zink JI, Brinker CJ (2013) Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. Acc Chem Res 46:792–801. https://doi.org/10.1021/ar300098610.1021/ar3000986 ↗
73. Tsema Y, Kichin G, Hellwig O, Mehta V, Kimel AV, Kirilyuk A, Rasing T (2016) Helicity and field dependent magnetization dynamics of ferromagnetic Co/Pt multilayers. Appl Phys Lett 109:072405. https://doi.org/10.1063/1.496124610.1063/1.4961246 ↗
74. Van Blaaderen A, Vrij A (1992) Synthesis and characterization of colloidal dispersions of fluorescent, monodisperse silica spheres. Langmuir 8:2921–2931. https://doi.org/10.1021/la00048a01310.1021/la00048a013 ↗
75. Verhaegh NAM, Van Blaaderen A (1994) Dispersions of rhodamine-labeled silica spheres: synthesis, characterization, and fluorescence confocal scanning laser microscopy. Langmuir 10:1427–1438. https://doi.org/10.1021/la00017a01910.1021/la00017a019 ↗
76. Walsh TR, Knecht MR (2017) Biointerface structural effects on the properties and applications of bioinspired peptide-based nanomaterials. Chem Rev 117:12641–12704. https://doi.org/10.1021/acs.chemrev.7b0013910.1021/acs.chemrev.7b00139 ↗
77. Wang X, Dong P, Yun W, Xu Y, He P, Fang Y (2009) A solid-state electrochemiluminescence biosensing switch for detection of thrombin based on ferrocene-labeled molecular beacon aptamer. Biosens Bioelectron 24:3288–3292. https://doi.org/10.1016/j.bios.2009.04.01910.1016/j.bios.2009.04.019 ↗
78. Wu L, Jubert P-O, Berman D, Imaino W, Nelson A, Zhu H, Zhang S, Sun S (2014) Monolayer assembly of ferrimagnetic CoxFe3–xO4 nanocubes for magnetic recording. Nano Lett 14:3395–3399. https://doi.org/10.1021/nl500904a10.1021/nl500904a ↗
79. Wu M-S, Shi H-W, Xu J-J, Chen H-Y (2011) CdS quantum dots/Ru(bpy)32+ electrochemiluminescence resonance energy transfer system for sensitive cytosensing. Chem Commun 47:7752–7754. https://doi.org/10.1039/C1CC12219C10.1039/C1CC12219C ↗
80. Wu W, He Q, Jiang C (2008) Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies. Nanoscale Res Lett 3:397–415. https://doi.org/10.1007/s11671-008-9174-910.1007/s11671-008-9174-9 ↗
81. Wu W, Wu Z, Yu T, Jiang C, Kim W-S (2015) Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications. Sci Technol Adv Mater 16:023501. https://doi.org/10.1088/1468-6996/16/2/02350110.1088/1468-6996/16/2/023501 ↗
82. Xie J, Chen K, Lee H-Y, Xu C, Hsu AR, Peng S, Chen X, Sun S (2008) Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin αvβ3-rich tumor cells. J Am Chem Soc 130:7542–7543. https://doi.org/10.1021/ja802003h10.1021/ja802003h ↗
83. Xu H, Cui L, Tong N, Gu H (2006) Development of high magnetization Fe3O4/polystyrene/silica nanospheres via combined miniemulsion/emulsion polymerization. J Am Chem Soc 128:15582–15583. https://doi.org/10.1021/ja066165a10.1021/ja066165a ↗
84. Xu J, Liang J, Li J, Yang W (2010) Multicolor dye-doped silica nanoparticles independent of FRET. Langmuir 26:15722–15725. https://doi.org/10.1021/la102849210.1021/la1028492 ↗
85. Xu Y, Qin Y, Palchoudhury S, Bao Y (2011) Water-soluble iron oxide nanoparticles with high stability and selective surface functionality. Langmuir 27:8990–8997. https://doi.org/10.1021/la201652h10.1021/la201652h ↗
86. Yao G, Wang L, Wu Y, Smith J, Xu J, Zhao W, Lee E, Tan W (2006) Flodots: luminescent nanoparticles. Anal Bioanal Chem 385(3):518–524. https://doi.org/10.1007/s00216-006-0452-z10.1007/s00216-006-0452-z ↗
87. Yin D, Liu B, Zhang L, Xie C, Zhang L (2010) Synthesis of Ru(bpy)3-doped silica nanoparticle and its application in fluorescent immunoassay. Nano Biomed Eng 2:117–120. https://doi.org/10.5101/nbe.v2i2.p117-12010.5101/nbe.v2i2.p117-120 ↗
88. Yokoi T, Sakamoto Y, Terasaki O, Kubota Y, Okubo T, Tatsumi T (2006) Periodic arrangement of silica nanospheres assisted by amino acids. J Am Chem Soc 128:13664–13665. https://doi.org/10.1021/ja065071y10.1021/ja065071y ↗
89. Yoo H, Pak J (2013) Synthesis of highly fluorescent silica nanoparticles in a reverse microemulsion through double-layered doping of organic fluorophores. J Nanopart Res 15:1609. https://doi.org/10.1007/s11051-013-1609-210.1007/s11051-013-1609-2 ↗
90. Yoon T-J, Yu KN, Kim E et al (2006) Specific targeting, cell sorting, and bioimaging with smart magnetic silica core–shell nanomaterials. Small 2:209–215. https://doi.org/10.1002/smll.20050036010.1002/smll.200500360 ↗
91. Yordanova T, Vasileva P, Karadjova I, Nihtianova D (2014) Submicron silica spheres decorated with silver nanoparticles as a new effective sorbent for inorganic mercury in surface waters. Analyst 139:1532–1540. https://doi.org/10.1039/C3AN01279D10.1039/C3AN01279D ↗
92. Zhao SY, Lee D-G, Kim C-W, Cha H-G, Kim Y-H, Kang Y-S (2006) Synthesis of magnetic nanoparticles of Fe3O4 and CoFe2O4 and their surface modification by surfactant adsorption. Bull Kor Chem Soc 27:237–242. https://doi.org/10.5012/bkcs.2006.27.2.23710.5012/bkcs.2006.27.2.237 ↗
93. Zhao W, Gu J, Zhang L, Chen H, Shi J (2005) Fabrication of uniform magnetic nanocomposite spheres with a magnetic core/mesoporous silica shell structure. J Am Chem Soc 127:8916–8917. https://doi.org/10.1021/ja051113r10.1021/ja051113r ↗