Development of lycopene-loaded lipid-core nanocapsules: physicochemical characterization and stability study
Source abstract
Abstract
The objective of this study was to develop lycopene-loaded lipid-core nanocapsules (Lyc-LNCs) by the interfacial deposition of preformed poly(e-caprolactone) (PCL). Lyc extract (93.9 %) was obtained from tomatoes, and the organic phase was prepared with polymer (PCL), caprylic/capric triglycerides, sorbitan monostearate, and Lyc in a mixture of acetone and ethanol under magnetic stirring at 40 °C. The organic phase was injected into an aqueous phase containing polysorbate 80, and the suspension was concentrated under reduced pressure. The formulation with a Lyc concentration of 85 µg/mL was characterized in terms of size distribution, zeta potential, encapsulation efficiency, pH, viscosity, and color. The Lyc-LNC formulation presented stable values for the z-average (193 ± 4.7 nm) and zeta potential (−11.5 ± 0.40 mV). Despite the lower pH, Lyc content, and color change of the suspension, the nanocapsules showed satisfactory stability, presenting around 50 % Lyc content after 14 days of storage at room temperature (25 °C).
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Proteins in Food Systems · Nanocomposite Films for Food Packaging · Microencapsulation and Drying Processes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (41)
Show source-provided references
1. Blanch GP, Ruiz del Castillo ML, del Mar Caja M, Pérez-Méndez M, Sánchez-Cortés S (2007) Stabilization of all-trans-lycopene from tomato by encapsulation using cyclodextrins. Food Chem 105:1335–134110.1016/j.foodchem.2007.04.060 ↗
2. Bramley PM (2000) Is lycopene beneficial to human health? Phytochemistry 54:233–23610.1016/S0031-9422(00)00103-5 ↗
3. Chiu YT, Chiu CP, Chien JT, Ho GH, Yang J, Chen BH (2007) Encapsulation of lycopene extract from tomato pulp waste with gelatin and poly(gamma-glutamic acid) as carrier. J Agric Food Chem 55:5123–513010.1021/jf0700069 ↗
4. Contri RV, Ribeiro KLF, Fiel LA, Pohlmann AR, Guterres SS (2013) Vegetable oils as core of cationic polymeric nanocapsules: influence on the physicochemical properties. J Exp Nanosci 8:913–92410.1080/17458080.2011.620019 ↗
5. Damodaran S (2008) Food chemistry. CRC Press, London
6. Dias MG, Camões MFGFC, Oliveira L (2014) Carotenoid stability in fruits, vegetables and working standards—effect of storage temperature and time. Food Chem 156:37–4110.1016/j.foodchem.2014.01.050 ↗
7. Dickinson E (2006) Food emulsions: principles, practices, and techniques, 2nd edition, Julian McClements. CRC Press, Boca Raton, FL (2005). Food Hydrocoll 20:13710.1016/j.foodhyd.2005.05.001 ↗
8. Fathi M, Mozafari MR, Mohebbi M (2012) Nanoencapsulation of food ingredients using lipid based delivery systems. Trends Food Sci Technol 23:13–2710.1016/j.tifs.2011.08.003 ↗
9. Fontana MC, Coradini K, Guterres SS, Pohlmann AR, Beck RCR (2009) Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system. J Biomed Nanotechnol 5:254–26310.1166/jbn.2009.1030 ↗
10. González-Reza RM, Quintanar-Guerrero D, Flores-Minutti JJ, Gutiérrez-Cortez E, Zambrano-Zaragoza ML (2014) Nanocapsules of β-carotene: thermal degradation kinetics in a scraped surface heat exchanger (SSHE). LWT - Food Sci Technol 60:124–13010.1016/j.lwt.2014.09.020 ↗
11. Goula AM, Adamopoulos KG (2012) A new technique for spray-dried encapsulation of lycopene. Dry Technol 30:641–65210.1080/07373937.2012.655871 ↗
12. Jager E, Venturini CG, Poletto FS, Colome LM, Pohlmann JPU, Bernardi A, Battastini AMO, Guterres SS, Pohlmann AR (2009) Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area. J Biomed Nanotechnol 5:130–14010.1166/jbn.2009.1004 ↗
13. Kasperczyk J, Hu Y, Jaworskam J, Dobrzynski P, Wei J, Li S (2008) Comparative study of the hydrolytic degradation of glycolide/l-lactide/epsilon-caprolactone terpolymers initiated by zirconium(IV) acetylacetonate or stannous octoate. J Appl Polym Sci 107:3258–326610.1002/app.27404 ↗
14. Kishore RSK, Kiese S, Fischer S, Pappenberger A, Grauschopf U, Mahler H-C (2011) The degradation of polysorbates 20 and 80 and its potential impact on the stability of biotherapeutics. Pharm Res 28:1194–121010.1007/s11095-011-0385-x ↗
15. Letchford K, Burt H (2007) A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur J Pharm Biopharm 65:259–26910.1016/j.ejpb.2006.11.009 ↗
16. Levy J, Bosin E, Feldman B, Giat Y, Miinster A, Danilenko M, Sharoni Y (1995) Lycopene is a more potent inhibitor of human cancer cell-proliferation than either alpha-carotene or beta-carotene. Nutr Cancer Int J 24:257–26610.1080/01635589509514415 ↗
17. Liu Y, Liu J, Chen X, Liu Y, Di D (2010) Preparative separation and purification of lycopene from tomato skins extracts by macroporous adsorption resins. Food Chem 123:1027–103410.1016/j.foodchem.2010.05.055 ↗
18. Lobato KBS, Paese K, Forgearini JC, Guterres SS, Jablonski A, Rios AO (2013) Characterisation and stability evaluation of bixin nanocapsules. Food Chem 141:3906–391210.1016/j.foodchem.2013.04.135 ↗
19. Matioli G, Rodriguez-Amaya DB (2003) Microencapsulação do licopeno com ciclodextrinas. Ciênc Tecnol Aliment 23:102–10510.1590/S0101-20612003000400019 ↗
20. Montenegro MA, Nunes IL, Mercadante AZ, Borsarelli CD (2007) Photoprotection of vitamins in skimmed milk by an aqueous soluble lycopene-gum arabic microcapsule. J Agric Food Chem 55:323–32910.1021/jf0622883 ↗
21. Moraru CI, Panchapakesan CP, Huang QR, Takhistov P, Liu S, Kokini JL (2003) Nanotechnology: a new frontier in food science. Food Technol 57:24–29
22. Nunes IL, Mercadante AZ (2004) Obtenção de cristais de licopeno a partir de descarte de tomate. Food Sci Technol (Camp) 24:440–44710.1590/S0101-20612004000300024 ↗
23. Onwulata CI (2013) Microencapsulation and functional bioactive foods. J Food Process Preserv 37:510–53210.1111/j.1745-4549.2012.00680.x ↗
24. Paese K, Jäger A, Poletto FS, Pinto EF, Rossi-Bergmann B, Pohlmann AR, Guterres SS (2009) Semisolid formulation containing a nanoencapsulated sunscreen: effectiveness, in vitro photostability and immune response. J Biomed Nanotechnol 5:240–24610.1166/jbn.2009.1028 ↗
25. Ribeiro HS, Chu B-S, Ichikawa S, Nakajima M (2008) Preparation of nanodispersions containing beta-carotene by solvent displacement method. Food Hydrocoll 22:12–1710.1016/j.foodhyd.2007.04.009 ↗
26. Rocha GA, Favaro-Trindade CS, Ferreira Grosso CR (2012) Microencapsulation of lycopene by spray drying: characterization, stability and application of microcapsules. Food Bioprod Process 90:37–4210.1016/j.fbp.2011.01.001 ↗
27. Rodriguez-Huezo ME, Pedroza-Islas R, Prado-Barragan LA, Beristain CI, Vernon-Carter EJ (2004) Microencapsulation by spray drying of multiple emulsions containing carotenoids. J Food Sci 69:E351–E35910.1111/j.1365-2621.2004.tb13641.x ↗
28. Sari TP, Mann B, Kumar R, Singh RRB, Sharma R, Bhardwaj M, Athira S (2015) Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocoll 43:540–54610.1016/j.foodhyd.2014.07.011 ↗
29. Schaffazick SR, Guterres SSU, Freitas LD, Pohlmann AR (2003) Physicochemical characterization and stability of the polymeric nanoparticle systems for drug administration. Quim Nova 26:726–73710.1590/S0100-40422003000500017 ↗
30. Sessa M, Casazza A, Perego P, Tsao R, Ferrari G, Donsì F (2013) Exploitation of polyphenolic extracts from grape marc as natural antioxidants by encapsulation in lipid-based nanodelivery systems. Food Bioprocess Technol 6:2609–262010.1007/s11947-012-0911-9 ↗
31. Shi J, Le Maguer M (2000) Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit Rev Biotechnol 20:293–33410.1080/07388550091144212 ↗
32. Shu B, Yu WL, Zhao YP, Liu XY (2006) Study on microencapsulation of lycopene by spray-drying. J Food Eng 76:664–66910.1016/j.jfoodeng.2005.05.062 ↗
33. Silva DF, Favaro-Trindade CS, Rocha GA, Thomazini M (2012) Microencapsulation of lycopene by gelatin–pectin complex coacervation. J Food Process Preserv 36:185–19010.1111/j.1745-4549.2011.00575.x ↗
34. Southon S (2000) Increased fruit and vegetable consumption within the EU: potential health benefits. Food Res Int 33:211–21710.1016/S0963-9969(00)00036-3 ↗
35. Tan CP, Nakajima M (2005) beta-Carotene nanodispersions: preparation, characterization and stability evaluation. Food Chem 92:661–67110.1016/j.foodchem.2004.08.044 ↗
36. Taylor TM, Davidson PM, Bruce BD, Weiss J (2005) Liposomal nanocapsules in food science and agriculture. Crit Rev Food Sci Nutr 45:587–60510.1080/10408390591001135 ↗
37. Valente Soares LM (2001) Como obter resultados confiáveis em cromatografia/how to obtain reliable results in chromatography. Rev Inst Adolfo Lutz 60(1):79–8410.53393/rial.2001.60.39304 ↗
38. Venturini CG, Jäger E, Oliveira CP, Bernardi A, Battastini AMO, Guterres SS, Pohlmann AR (2011) Formulation of lipid core nanocapsules. Colloids Surf A 375:200–20810.1016/j.colsurfa.2010.12.011 ↗
39. Wu L, Zhang J, Watanabe W (2011) Physical and chemical stability of drug nanoparticles. Adv Drug Deliv Rev 63:456–46910.1016/j.addr.2011.02.001 ↗
40. Yuan Y, Gao Y, Zhao J, Mao L (2008) Characterization and stability evaluation of beta-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions. Food Res Int 41:61–6810.1016/j.foodres.2007.09.006 ↗
41. Zhuang C-Y, Li N, Wang M, Zhang X-N, Pan W-S, Peng J-J, Pan Y-S, Tang X (2010) Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm 394:179–18510.1016/j.ijpharm.2010.05.005 ↗