Osteoblast and Chrondrocyte Proliferation in the Presence of Alumina And Titania Nanoparticles
Source abstract
Abstract
Proliferation of osteoblasts (bone-forming cells) and chondrocytes (cartilage-synthesizing cells) exposed to different sizes of alumina as well as titania particles at various concentrations (from 10,000 to 100 μg/ml of culture media) was investigated in the present in vitro study. Compared to respective conventional (i.e., micron) particle size ceramics, results provided the first evidence of increased osteoblast and chondrocyte proliferation in the presence of nanoparticles. Material characterization studies revealed that the only difference between respective ceramic particles was nano- and conventional-dimensions; specifically, phase, charge, and chemical properties were similar between different size alumina and titania particles, respectively. Thus, the present study provided the first evidence of a less detrimental effect of nano- as compared to conventional-dimension wear debris on cell function; such wear debris may result from friction between articulating components of orthopedic implants composed of novel nanophase ceramic materials. In this manner, results provided additional evidence to the literature that nanophase ceramics may become the next generation of bone prosthetic materials with improved osseointegrative (i.e., ability to bond to juxtaposed bone in situ) properties.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (34)
Show source-provided references
1. Allen M.J., B.J. Myer, P.J. Millett & N. Rushton, 1997. The effects of particulate cobalt, chromium and cobalt-chromium alloy on human osteoblast-like cells in vitro. J. Bone Joint Surg. British 79, 475–482.10.1302/0301-620X.79B3.0790475 ↗
2. Brunski J.B., 1991. Influence of biomechanical factors at the bone-biomaterial interface. In: Davies J.E., ed. The Bone-Biomaterial Interface, University of Toronto Press, Toronto, pp. 391–404.
3. Buly R.L., M.H. Huo, E. Salvati, W. Brein & M. Bansal, 1992. Titanium wear debris in failed cemented total hip arthroplasty. An analysis of 71 cases. J. Arthroplasty 7, 315–323.10.1016/0883-5403(92)90056-V ↗
4. Dean D.D., C.H. Lohmann, V.L. Sylvia, G. Koster, Y. Liu, Z. Schwartz & B.D. Boyan, 2001. Effect of polymer molecular weight and addition of calcium state on response of MG63 osteobl-like cells to UHMWPE particles. J. Orthoped. Res. 19, 179–186.10.1016/S0736-0266(00)00030-9 ↗
5. DeHeer D.H., J.A. Engles, A.S. DeVries, R.H. Knapp & J.D. Beebe, 2001. In situ complement activation by polyethylene wear debris. J. Biomed. Mater. Res. 54, 12–19.10.1002/1097-4636(200101)54:1<12::AID-JBM2>3.0.CO;2-X ↗
6. Green T.R., J. Fisher, M. Stone, B.M. Wroblewski & E. Ingham, 1998. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro. Biomaterials 19, 2297–2302.10.1016/S0142-9612(98)00140-9 ↗
7. Hashiguchi T., T. Hirano, H. Shindo & K. Baba, 1999. Wear of alumina prosthesis. Arch. Orthoped. Trauma Surg. 119, 30–34.10.1007/s004020050350 ↗
8. Horikoshi M., J. Dowd, W. Maloney, L. Crossett & H. Rubash, 1994. Activation of human fibroblasts and macrophages by particulate wear debris from failed total hip and total knee arthroplasty. Trans. Orthoped. Res. 20, 199–201.
9. Kaplan F.S., W.C. Hayes, T.M. Keaveny, A. Boskey, T.A. Einhorn & J.P. Iannotti, 1994. Orthopedic Basic Science, American Academy of Orthopedic Surgery, Columbus OH.
10. Kobayashi A., W. Bonfield, Y. Kadoya, T. Yamac, M.A. Freeman, G. Scott & P.A. Revell, 1997. The size and shape of particulate polyethylene wear debris in total joint replacements. Proceedings of the Institution of Mechanical Engineering. Part H-J. Eng. Med. 211, 11–15.10.1243/0954411971534638 ↗
11. Kohilas K., M. Lyons, R. Lofthouse, C.G. Frondoza, R. Jinnah & D.S. Hungerford, 1999. Effect of prosthetic titanium wear debris on mitogen-induced monocyte and lymphoid activation. J. Biomed. Mater. Res. 47, 95–103.10.1002/(SICI)1097-4636(199910)47:1<95::AID-JBM14>3.0.CO;2-8 ↗
12. Kwon S.Y., H. Takei, D.P. Pioletti, T. Lin, Q.J. Ma, W.H. Akeson, D.J. Wood & K.L. Sung, 2000. Titanium particles inhibit osteoblast adhesion to fibronectin-coated substrates. J. Orthoped. Res. 18, 203–211.10.1002/jor.1100180207 ↗
13. Lerouge S., O. Huk, L.H. Yahia & L. Sedel, 1996. Characterization of in vivo wear debris from ceramic-ceramic total hip arthroplasties. J. Biomed. Mater. Res. 32, 627–633.10.1002/(SICI)1097-4636(199612)32:4<627::AID-JBM16>3.0.CO;2-A ↗
14. Lohmann C.H., Z. Schwartz, G. Koster, U. Jahn, G.H. Buchhorn, M.J. MacDougall, D. Casasola, Y. Liu, V.L. Sylvia, D.D. Dean & B.D. Boyan, 2000. Phagocytosis of wear debris by osteoblasts affects differentiation and local factor production in a manner dependent on particle composition. Biomaterials 21, 551–561.10.1016/S0142-9612(99)00211-2 ↗
15. Martinez M.E., S. Medina, M.T. del Campo, J.A. Garcia, A. Rodrigo & L. Munuera, 1998. Effect of polyethylene particles on human osteoblastic cell growth. Biomaterials 19, 183–187.10.1016/S0142-9612(97)00250-0 ↗
16. Montgomery D., 1991. Design and Analysis of Experiments, 3rd edn. John Wiley and Sons, New York, NY.
17. Oparaugo P.C., I.C. Clarke, H. Malchau & P. Herberts, 2001. Correlation of wear debris-induced osteolysis and revision with volumetric wear-rated of polyethylene: A survey of 8 reports in the literature. Acta Orthopaed. Scandavica 72, 22–28.10.1080/000164701753606644 ↗
18. Pioletti D.P., H. Takei, S.Y. Kwon, D. Wood & K.L. Sung, 1999. The cytotoxic effect of titanium particles phagocytosed by osteoblasts. J. Biomed. Mater. Res. 46, 399–407.10.1002/(SICI)1097-4636(19990905)46:3<399::AID-JBM13>3.0.CO;2-B ↗
19. Rodrigo A.M., M.E. Martinez, P. Martinez, M.L. Escudero, J. Ruiz, L. Saldana, L. Gomez-Garcia, L. Fernandez, I. del Valle & L. Munuera, 2001. Effects of MA 956 superalloy and α-alumina particles in some markers of human osteoblastic cells in primary culture. J. Biomed. Mater. Res. 54, 30–36.10.1002/1097-4636(200101)54:1<30::AID-JBM4>3.0.CO;2-V ↗
20. Savio J.A. 3rd, L.M. Overcamp & J. Black, 1994. Size and shape of biomaterial wear debris. Clinical Materials 15, 101–147.10.1016/0267-6605(94)90076-0 ↗
21. Schanbhag A.S., J.J. Jacobs, T.T. Glant, J.L. Gilbert, J. Black & J.O. Galante, 1994. Composition and morphology of wear debris in failed uncemented total hip replacement. J. Bone Joint Surg. 76, 60–67.10.1302/0301-620X.76B1.8300684 ↗
22. Schanbhag A.S., J.J. Jacobs, J. Black, J.O. Galante & T.T. Glant, 1997. Effects of particles on fibroblast proliferation and bone resorption in vitro. Clin. Orthopaed. Relat. Res. 342, 205–217.
23. Urban R.M., J.J. Jacobs, M.J. Tomlinson, J. Gavrilovic, J. Black & M. Peoc'h, 2000. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J. Bone Joint Surg.-Am. 82, 457–476.10.2106/00004623-200004000-00002 ↗
24. Vermes C., R. Chandrasekaran, J.J. Jacobs, J.O. Galante, K.A. Roebuck & T.T. Glant, 2001. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J. Bone Joint Surg.-Am. 83, 201–211.10.2106/00004623-200102000-00007 ↗
25. Webster T.J., R.W. Siegel & R. Bizios, 1998. An in vitro evaluation of nanophase alumina for orthopaedic/dental applications. In: LeGeros R.Z. and LeGeros J.P., eds. Bioceramics 11: Proceedings of the 11th International Symposium on Ceramics in Medicine, World Scientific, New York, pp. 273–276.
26. Webster T.J., R.W. Siegel & R. Bizios, 1999a. Design and evaluation of nanophase alumina for orthopaedic/dental applications. Nanostruct. Mater. 12, 983–986.10.1016/S0965-9773(99)00283-4 ↗
27. WebsterT.J., R.W. Siegel & R. Bizios, 1999b. Osteoblast adhesion on nanophase ceramics. Biomaterials 20, 1221–1227.10.1016/S0142-9612(99)00020-4 ↗
28. Webster T.J., C. Ergun, R.H. Doremus, R.W. Siegel & R. Bizios, 2000a. Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics. J. Biomed. Mater. Res. 51(3), 475–483.10.1002/1097-4636(20000905)51:3<475::AID-JBM23>3.0.CO;2-9 ↗
29. Webster T.J., R.W. Siegel & R. Bizios, 2000b. Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 21, 1803–1810.10.1016/S0142-9612(00)00075-2 ↗
30. Webster T.J., R.W. Siegel & R. Bizios, 2000c. Enhanced surface and mechanical properties of nanophase ceramics to achieve orthopaedic/dental implant efficacy. In: Giannini S. and Moroni A., eds. Bioceramics 13: Proceedings of the 13th International Symposium on Ceramics in Medicine, Trans Tech Publications, Switzerland, pp. 321–324.
31. Webster T.J., R.W. Siegel & R. Bizios, 2001a. Enhanced surface and mechanical properties of nanophase ceramics to achieve orthopaedic/dental implant efficacy. Key Eng. Mater. 192–195, 321–324.
32. Webster T.J., L.S. Schadler, R.W. Siegel & R. Bizios, 2001b. Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin. Tissue Eng. 7(3), 291–301.10.1089/10763270152044152 ↗
33. Webster T.J., C. Ergun, R.H. Doremus, R.W. Siegel & R. Bizios, 2001c. Enhanced functions of osteoclast-like cells on nanophase ceramics. Biomaterials 22(11), 1327–1333.10.1016/S0142-9612(00)00285-4 ↗
34. Webster T.J., R.W. Siegel & R. Bizios, 2001d. Nanoceramic surface roughness enhances osteoblast and osteoclast functions for improved orthopaedic/dental implant efficacy. Scripta Mater. 44, 1639–1642.10.1016/S1359-6462(01)00873-9 ↗