Application and perspectives of nanopesticides in agriculture
Source abstract
Abstract
Nanopesticide is an important application of nanotechnology in the agriculture for the past 20 years, which has received significant attention in controlled release and targeted transport as well as reduced dosage, with sizes typically less than 100 nm and large relative surface area. Despite the great role played by nanopesticides in pest and disease control, their toxicological effects cannot be ignored. But the state of knowledge on the biotoxicological effects of nanopesticides is limited, particularly regarding to their environmental fate and behavior. Based on this situation, we discuss the characteristics and applications of five examples of nanopesticide formulations whose nanomaterials react with active ingredients; we analyze the behavior and ecotoxicity of nanopesticides in the environment, mainly in soil and the three aspects of toxic effects; and we discuss the issues that need attention in risk assessment and management. Although there are some challenges and concerns about nanopesticides, in the long run, nanopesticides are worthy of further study and have good prospects for development.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Pesticide and Herbicide Environmental Studies · Polymer-Based Agricultural Enhancements · Insect and Pesticide Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Zhao X, Cui HX, Wang Y, Sun CJ, Cui B, Zeng ZH (2018) Development strategies and prospects of nano-based smart pesticide formulation. J Agric Food Chem 26:6504–6512. https://doi.org/10.1021/acs.jafc.7b0200410.1021/acs.jafc.7b02004 ↗
2. Liang Y, Guo MC, Fan C, Dong HQ, Ding GL, Zhang WB, Tang G, Yang JL, Kong DD, Cao YS (2017) Development of novel urease-responsive pendimethalin microcapsules using silica-IPTS-PEI As controlled release carrier materials. ACS Sustain Chem Eng 6:4802–4810. https://doi.org/10.1021/acssuschemeng.7b0020810.1021/acssuschemeng.7b00208 ↗
3. Mall D, Larsen AE, Martin EA (2018) Investigating the (mis)match between natural pest control knowledge and the intensity of pesticide use. Insects 9(1):2. https://doi.org/10.3390/insects901000210.3390/insects9010002 ↗
4. Osorio-Echavarria J, Osorio-Echavarria J, Ossa-Orozco CP, Gomez-Vanegas NA (2021) Synthesis of silver nanoparticles using white-rot fungus Anamorphous Bjerkandera sp. R1: influence of silver nitrate concentration and fungus growth time. Sci Rep 11(1):3842. https://doi.org/10.1038/s41598-021-82514-810.1038/s41598-021-82514-8 ↗
5. Fu B, Li Q, Qiu H, Tang L, Zeng D, Liu K, Gao Y (2018) Resistance development, stability, cross-resistance potential, biological fitness and biochemical mechanisms of spinetoram resistance in Thrips hawaiiensis (Thysanoptera: Thripidae). Pest Manag Sci 7:1564–1574. https://doi.org/10.1002/ps.488710.1002/ps.4887 ↗
6. Prasad R, Bhattacharyya A, Nguyen QD (2017) Nanotechnology in sustainable agriculture: recent developments, challenges, and perspectives. Front Microbiol 8:1014. https://doi.org/10.3389/fmicb.2017.0101410.3389/fmicb.2017.01014 ↗
7. Vurro M, Miguel-Rojas C, Perez-de-Luque A (2019) Safe nanotechnologies for increasing the effectiveness of environmentally friendly natural agrochemicals. Pest Manag Sci 9:2403–2412. https://doi.org/10.1002/ps.534810.1002/ps.5348 ↗
8. Bocca B, Barone F, Petrucci F, Benetti F, Picardo V, Prota V, Amendola G (2020) Nanopesticides: Physico-chemical characterization by a combination of advanced analytical techniques. Food Chem Toxicol 146:111816. https://doi.org/10.1016/j.fct.2020.11181610.1016/j.fct.2020.111816 ↗
9. Group CW (2019) Ten chemical innovations that will change our world. Chemical Weekly 7:65
10. Kah M, Kookana RS, Gogos A, Bucheli TD (2018) A critical evaluation of nanopesticides and nanofertilizers against their conventional analogues. Nat Nanotechnol 8:677–684. https://doi.org/10.1038/s41565-018-0131-110.1038/s41565-018-0131-1 ↗
11. He X, Hwang HM (2016) Nanotechnology in food science: functionality, applicability, and safety assessment. J Food Drug Anal 4:671–681. https://doi.org/10.1016/j.jfda.2016.06.00110.1016/j.jfda.2016.06.001 ↗
12. He X, Fu P, Aker WG, Hwang HM (2018) Toxicity of engineered nanomaterials mediated by nano-bio-eco interactions. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 1:21–42. https://doi.org/10.1080/10590501.2017.141879310.1080/10590501.2017.1418793 ↗
13. Ray P, Alhalhooly L, Ghosh A, Choi Y, Banerjee S, Mallik S, Banerjee S, Quadir M (2019) Size-transformable, multifunctional nanoparticles from hyperbranched polymers for environment-specific therapeutic delivery. ACS Biomater Sci Eng 3:1354–1365. https://doi.org/10.1021/acsbiomaterials.8b0160810.1021/acsbiomaterials.8b01608 ↗
14. Cătălin Balaure P, Gudovan D, Gudovan I (2017) 4-Nanopesticides: a new paradigm in crop protection. In: New Pesticides and Soil Sensors. Academic Press, pp 129–192. https://doi.org/10.1016/B978-0-12-804299-1.00005-910.1016/B978-0-12-804299-1.00005-9 ↗
15. Ali MA, Rehman I, Iqbal A, Din S, Rao AQ, Latif A, Samiullah TR, Azam S, Husnain T (2014) Nanotechnology, a new frontier in Agriculture. Adv Life Sci 1(3):129–138
16. Gao Y, Xiao Y, Mao K, Qin X, Zhang Y, Li D, Zhang Y, Li J, Wan H, He S (2020) Thermoresponsive polymer-encapsulated hollow mesoporous silica nanoparticles and their application in insecticide delivery. Chem Eng J 383:123169. https://doi.org/10.1016/j.cej.2019.12316910.1016/j.cej.2019.123169 ↗
17. Memarizadeh N, Ghadamyari M, Adeli M, Talebi K (2014) Preparation, characterization and efficiency of nanoencapsulated imidacloprid under laboratory conditions. Ecotoxicol Environ Saf 107:77–83. https://doi.org/10.1016/j.ecoenv.2014.05.00910.1016/j.ecoenv.2014.05.009 ↗
18. Huang B, Chen F, Shen Y, Qian K, Wang Y, Sun C, Zhao X, Cui B, Gao F, Zeng Z, Cui H (2018) Advances in targeted pesticides with environmentally responsive controlled release by nanotechnology. Nanomater (Basel) 8(2):102. https://doi.org/10.3390/nano802010210.3390/nano8020102 ↗
19. Dong J, Chen W, Feng J, Liu X, Xu Y, Wang C, Yang WDX (2021) Facile, smart, and degradable metal-organic framework nanopesticides gated with Fe(III)-Tannic acid networks in response to seven biological and environmental stimuli. ACS Appl Mater Interfaces 16:19507–19520. https://doi.org/10.1021/acsami.1c0411810.1021/acsami.1c04118 ↗
20. Tang J, Ding G, Niu J, Zhang W, Tang G, Liang Y, Fan C, Dong H, Yang J, Li J, Cao Y (2019) Preparation and characterization of tebuconazole metal-organic framework-based microcapsules with dual-microbicidal activity. Chem Eng J 359:225–232. https://doi.org/10.1016/j.cej.2018.11.14710.1016/j.cej.2018.11.147 ↗
21. Sandhya KS, Kumar D, Dilbaghi N (2017) Preparation, characterization, and bio-efficacy evaluation of controlled release carbendazim-loaded polymeric nanoparticles. Environ Sci Pollut Res Int 1:926–937. https://doi.org/10.1007/s11356-016-7774-y10.1007/s11356-016-7774-y ↗
22. Nuruzzaman M, Rahman MM, Liu Y, Naidu R (2016) Nanoencapsulation, nano-guard for pesticides: a new window for safe application. J Agric Food Chem 7:1447–1483. https://doi.org/10.1021/acs.jafc.5b0521410.1021/acs.jafc.5b05214 ↗
23. Xu T, Wang Y, Aytac Z, Zuverza-Mena N, Zhao Z, Hu X, Ng KW, White JC, Demokritou P (2022) Enhancing agrichemical delivery and plant development with biopolymer-based stimuli responsive core-shell nanostructures. ACS Nano 4:6034–6048. https://doi.org/10.1021/acsnano.1c1149010.1021/acsnano.1c11490 ↗
24. Bombo AB, Pereira AES, Lusa MG, de Medeiros OE, de Oliveira JL, Campos EVR, de Jesus MB, Oliveira HC, Fraceto LF, JLS M (2019) A mechanistic view of interactions of a nanoherbicide with target organism. J Agric Food Chem 16:4453–4462. https://doi.org/10.1021/acs.jafc.9b0080610.1021/acs.jafc.9b00806 ↗
25. Pereira AE, Grillo R, Mello NF, Rosa AH, Fraceto LF (2014) Application of poly(epsilon-caprolactone) nanoparticles containing atrazine herbicide as an alternative technique to control weeds and reduce damage to the environment. J Hazard Mater 268:207–215. https://doi.org/10.1016/j.jhazmat.2014.01.02510.1016/j.jhazmat.2014.01.025 ↗
26. Oliveira HC, Stolf-Moreira R, Martinez CB, Sousa GF, Grillo R, de Jesus MB, Fraceto LF (2015) Evaluation of the side effects of poly(epsilon-caprolactone) nanocapsules containing atrazine toward maize plants. Front Chem 3:61. https://doi.org/10.3389/fchem.2015.0006110.3389/fchem.2015.00061 ↗
27. Wang N, Lin QI, Wang Y, Xiaogang LI (2017) Preparation and performance of thermo-sensitive pyraclostrobin microcapsules. Chin J Pest Sci 19(3):381–387
28. Li D, Liu B, Yang F, Wang X, Shen HWD (2016) Preparation of uniform starch microcapsules by premix membrane emulsion for controlled release of avermectin. Carbohydr Polym 136:341–349. https://doi.org/10.1016/j.carbpol.2015.09.05010.1016/j.carbpol.2015.09.050 ↗
29. Liu B, Wang Y, Yang F, Wang X, Shen H, Cui HWD (2016) Construction of a controlled-release delivery system for pesticides using biodegradable PLA-based microcapsules. Colloids Surf B: Biointerfaces 144:38–45. https://doi.org/10.1016/j.colsurfb.2016.03.08410.1016/j.colsurfb.2016.03.084 ↗
30. Esmaeili A, Saremnia B (2012) Preparation of extract-loaded nanocapsules from Onopordon leptolepis DC. Ind Crop Prod 1:259–263. https://doi.org/10.1016/j.indcrop.2011.12.01010.1016/j.indcrop.2011.12.010 ↗
31. Kah M, Beulke S, Tiede K, Hofmann T (2013) Nanopesticides: state of knowledge, environmental fate, and exposure modeling. Crit Rev Environ Sci Technol 16:1823–1867. https://doi.org/10.1080/10643389.2012.67175010.1080/10643389.2012.671750 ↗
32. Ezhilarasi PN, Karthik P, Chhanwal N, Anandharamakrishnan C (2012) Nanoencapsulation techniques for food bioactive components: a review. Food Bioprocess Technol 3:628–647. https://doi.org/10.1007/s11947-012-0944-010.1007/s11947-012-0944-0 ↗
33. Wanyika H (2013) Sustained release of fungicide metalaxyl by mesoporous silica nanospheres. In: Nanotechnology for Sustainable Development. Springer International Publishing, pp 321–329. https://doi.org/10.1007/978-3-319-05041-6_2510.1007/978-3-319-05041-6_25 ↗
34. Tang FQ, Li LL, Chen D (2012) Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery. Adv Mater 12:1504–1534. https://doi.org/10.1002/adma.20110476310.1002/adma.201104763 ↗
35. Wang X, Yucel T, Lu Q, Hu X, Kaplan DL (2010) Silk nanospheres and microspheres from silk/pva blend films for drug delivery. Biomaterials 6:1025–1035. https://doi.org/10.1016/j.biomaterials.2009.11.00210.1016/j.biomaterials.2009.11.002 ↗
36. Feng C, Wang Z, Jiang C, Kong M, Zhou X, Li Y, Cheng X, Chen X (2013) Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: in vitro and in vivo evaluation. Int J Pharm 1:158–167. https://doi.org/10.1016/j.ijpharm.2013.07.07910.1016/j.ijpharm.2013.07.079 ↗
37. Ye Z, Guo J, Wu D, Tan M, Xiong X, Yin Y, He G (2015) Photo-responsive shell cross-linked micelles based on carboxymethyl chitosan and their application in controlled release of pesticide. Carbohydr Polym 132:520–528. https://doi.org/10.1016/j.carbpol.2015.06.07710.1016/j.carbpol.2015.06.077 ↗
38. Jing Z, Xue-Hua J (2019) Formulation conditions on the drug loading properties of polymeric micelles. Pak J Pharm Sci 32:607–615
39. Zhang J, Li M, Fan T, Xu Q, Wu Y, Chen C, Huang Q (2013) Construction of novel amphiphilic chitosan copolymer nanoparticles for chlorpyrifos delivery. J Polym Res 20:1–11. https://doi.org/10.1007/s10965-013-0107-710.1007/s10965-013-0107-7 ↗
40. Bhagat D, Samanta SK, Bhattacharya S (2013) Efficient management of fruit pests by pheromone nanogels. Sci Rep 3:1294. https://doi.org/10.1038/srep0129410.1038/srep01294 ↗
41. Rigogliuso S, Sabatino MA, Adamo G, Grimaldi N, Ghersi G (2012) Polymeric nanogels: Nanocarriers for drug delivery application. Chemical. Eng Trans 27:247–252
42. Paula HCB, Sombra FM, Cavalcante RF, FOM A, RCM SP (2011) Preparation and characterization of chitosan/cashew gum beads loaded with Lippia sidoides essential oil. Mater Sci Eng C 2:173–178. https://doi.org/10.1016/j.msec.2010.08.01310.1016/j.msec.2010.08.013 ↗
43. Kashyap PL, Xiang X, Heiden P (2015) Chitosan nanoparticle based delivery systems for sustainable agriculture. Int J Biol Macromol 77:36–51. https://doi.org/10.1016/j.ijbiomac.2015.02.03910.1016/j.ijbiomac.2015.02.039 ↗
44. Malerba M, Cerana R (2016) Chitosan effects on plant systems. Int J Mol Sci 17:996. https://doi.org/10.3390/ijms1707099610.3390/ijms17070996 ↗
45. Nadendla SR, Rani TS, Vaikuntapu PR, Maddu RR, Podile AR (2018) HarpinPss encapsulation in chitosan nanoparticles for improved bioavailability and disease resistance in tomato. Carbohydr Polym 199:11–19. https://doi.org/10.1016/j.carbpol.2018.06.09410.1016/j.carbpol.2018.06.094 ↗
46. Xiang C, Taylor AG, Hinestroza JP, Frey MW (2013) Controlled release of nonionic compounds from poly(lactic acid)/cellulose nanocrystal nanocomposite fibers. J Appl Polym Sci 1:79–86. https://doi.org/10.1002/app.3694310.1002/app.36943 ↗
47. Kah M, Hofmann T (2014) Nanopesticide research: current trends and future priorities. Environ Int 63:224–235. https://doi.org/10.1016/j.envint.2013.11.01510.1016/j.envint.2013.11.015 ↗
48. Sujitha V, Murugan K, Dinesh D, Pandiyan A, Aruliah R, Hwang JS, Kalimuthu K, Panneerselvam C, Higuchi A, Aziz AT, Kumar S, Alarfaj AA, Vaseeharan B, Canale A, Benelli G (2017) Green-synthesized CdS nano-pesticides: Toxicity on young instars of malaria vectors and impact on enzymatic activities of the non-target mud crab Scylla serrata. Aquat Toxicol 188:100–108. https://doi.org/10.1016/j.aquatox.2017.04.01510.1016/j.aquatox.2017.04.015 ↗
49. Coutris C, Hertel-Aas T, Lapied E, Joner EJ, Oughton DH (2012) Bioavailability of cobalt and silver nanoparticles to the earthworm Eisenia fetida. Nanotoxicology 2:186–195. https://doi.org/10.3109/17435390.2011.56909410.3109/17435390.2011.569094 ↗
50. Kookana RS, Boxall AB, Reeves PT, Ashauer R, Beulke S, Chaudhry Q, Cornelis G, Fernandes TF, Gan J, Kah M, Lynch I, Ranville J, Sinclair C, Spurgeon D, Tiede K, Van den Brink PJ (2014) Nanopesticides: guiding principles for regulatory evaluation of environmental risks. J Agric Food Chem 19:4227–4240. https://doi.org/10.1021/jf500232f10.1021/jf500232f ↗
51. Gao J, Powers K, Wang Y, Zhou H, Roberts SM, Moudgil BM, Koopman B, Barber DS (2012) Influence of Suwannee River humic acid on particle properties and toxicity of silver nanoparticles. Chemosphere 1:96–101. https://doi.org/10.1016/j.chemosphere.2012.04.02410.1016/j.chemosphere.2012.04.024 ↗
52. Saini P, Gopal M, Kumar R, Srivastava C (2014) Development of pyridalyl nanocapsule suspension for efficient management of tomato fruit and shoot borer (Helicoverpa armigera). J Environ Sci Health B 5:344–351. https://doi.org/10.1080/03601234.2014.88216810.1080/03601234.2014.882168 ↗
53. Suresh Kumar RS, Shiny PJ, Anjali CH, Jerobin J, Goshen KM, Magdassi S, Mukherjee A, Chandrasekaran N (2013) Distinctive effects of nano-sized permethrin in the environment. Environ Sci Pollut Res Int 4:2593–2602. https://doi.org/10.1007/s11356-012-1161-010.1007/s11356-012-1161-0 ↗
54. Grillo R, Fraceto LF, Amorim MJB, Scott-Fordsmand JJ, Schoonjans R, Chaudhry Q (2021) Ecotoxicological and regulatory aspects of environmental sustainability of nanopesticides. J Hazard Mater 404:124148. https://doi.org/10.1016/j.jhazmat.2020.12414810.1016/j.jhazmat.2020.124148 ↗
55. Taverna ME, Busatto CA, Lescano MR, Nicolau VV, Zalazar CS, Meira GR, Estenoz DA (2018) Microparticles based on ionic and organosolv lignins for the controlled release of atrazine. J Hazard Mater 359:139–147. https://doi.org/10.1016/j.jhazmat.2018.07.01010.1016/j.jhazmat.2018.07.010 ↗
56. Grillo R, Rosa AH, Fraceto LF (2015) Engineered nanoparticles and organic matter: a review of the state-of-the-art. Chemosphere 119:608–619. https://doi.org/10.1016/j.chemosphere.2014.07.04910.1016/j.chemosphere.2014.07.049 ↗
57. Wang D, Bradford SA, Harvey RW, Gao B, Cang L, Zhou D (2012) Humic acid facilitates the transport of ARS-labeled hydroxyapatite nanoparticles in iron oxyhydroxide-coated sand. Environ Sci Technol 5:2738–2745. https://doi.org/10.1021/es203784u10.1021/es203784u ↗
58. Ng CM, Weston DP, Lydy MJ (2012) Pyrethroid insecticide transport into Monterey Bay through riverine suspended solids. Arch Environ Contam Toxicol 4:461–470. https://doi.org/10.1007/s00244-012-9796-x10.1007/s00244-012-9796-x ↗
59. Tvon H, der Kammer F (2009) Estimating the relevance of engineered carbonaceous nanoparticle facilitated transport of hydrophobic organic contaminants in porous media. Environ Pollut 4:1117–1126. https://doi.org/10.1016/j.envpol.2008.10.02210.1016/j.envpol.2008.10.022 ↗
60. Kah M, Weniger AK, Hofmann T (2016) Impacts of (nano)formulations on the fate of an insecticide in soil and consequences for environmental exposure assessment. Environ Sci Technol 20:10960–10967. https://doi.org/10.1021/acs.est.6b0247710.1021/acs.est.6b02477 ↗
61. Kah M, Walch H, Hofmann T (2018) Environmental fate of nanopesticides: durability, sorption and photodegradation of nanoformulated clothianidin. Environ Sci Nano 4:882–889. https://doi.org/10.1039/c8en00038g10.1039/c8en00038g ↗
62. Shi J, Ye J, Fang H, Zhang SXC (2018) Effects of copper oxide nanoparticles on paddy soil properties and components. Nanomater (Basel) 8:839. https://doi.org/10.3390/nano810083910.3390/nano8100839 ↗
63. Hao Y, Ma C, Zhang Z, Song Y, Cao W, Guo J, Zhou G, Rui Y, Liu L, Xing B (2018) Carbon nanomaterials alter plant physiology and soil bacterial community composition in a rice-soil-bacterial ecosystem. Environ Pollut 232:123–136. https://doi.org/10.1016/j.envpol.2017.09.02410.1016/j.envpol.2017.09.024 ↗
64. Collin B, Oostveen E, Tsyusko O, V., Unrine, JasonM. (2014) Influence of natural organic matter and surface charge on the toxicity and bioaccumulation of functionalized ceria nanoparticles in caenorhabditis elegans. Environ Sci Technol 2:1280–128910.1021/es404503c ↗
65. Velicogna JR, Ritchie EE, Scroggins RP, Princz JI (2016) A comparison of the effects of silver nanoparticles and silver nitrate on a suite of soil dwelling organisms in two field soils. Nanotoxicology 8:1144–1151. https://doi.org/10.1080/17435390.2016.118180710.1080/17435390.2016.1181807 ↗
66. Schlich K, Hoppe M, Kraas M, Schubert J, Chanana M, Hund-Rinke K (2018) Long-term effects of three different silver sulfide nanomaterials, silver nitrate and bulk silver sulfide on soil microorganisms and plants. Environ Pollut Pt B 242:1850–1859. https://doi.org/10.1016/j.envpol.2018.07.08210.1016/j.envpol.2018.07.082 ↗
67. Zhang H, Du W, Peralta-Videa JR, Gardea-Torresdey JL, White JC, Keller A, Guo H, Ji R, Zhao L (2018) Metabolomics reveals how cucumber ( Cucumis sativus) reprograms metabolites to cope with silver ions and silver nanoparticle-induced oxidative stress. Environ Sci Technol 14:8016–8026. https://doi.org/10.1021/acs.est.8b0244010.1021/acs.est.8b02440 ↗
68. Gogos A, Knauer K, Bucheli TD (2012) Nanomaterials in plant protection and fertilization: current state, foreseen applications, and research priorities. J Agric Food Chem 39:9781–9792. https://doi.org/10.1021/jf302154y10.1021/jf302154y ↗
69. Zhang X, Xu Z, Qian X, Lin D, Zeng T, Filser J, Li L, Kah M (2020) Assessing the impacts of Cu(OH)2 nanopesticide and ionic copper on the soil enzyme activity and bacterial community. J Agric Food Chem 11:3372–3381. https://doi.org/10.1021/acs.jafc.9b0632510.1021/acs.jafc.9b06325 ↗
70. Hannon JC, Kerry JP, Cruz-Romero M, Azlin-Hasim S, Morris M, Cummins E (2016) Assessment of the migration potential of nanosilver from nanoparticle-coated low-density polyethylene food packaging into food simulants. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 1:167–178. https://doi.org/10.1080/19440049.2015.111418410.1080/19440049.2015.1114184 ↗
71. Anreddy RNR (2018) Copper oxide nanoparticles induces oxidative stress and liver toxicity in rats following oral exposure. Toxicol Rep 5:903–90410.1016/j.toxrep.2018.08.022 ↗
72. Schnoor B, Elhendawy A, Joseph S, Putman M, Chacon-Cerdas R, Flores-Mora D, Bravo-Moraga F, Gonzalez-Nilo F, Salvador-Morales C (2018) Engineering atrazine loaded poly (lactic- co-glycolic acid) nanoparticles to ameliorate environmental challenges. J Agric Food Chem 30:7889–7898. https://doi.org/10.1021/acs.jafc.8b0191110.1021/acs.jafc.8b01911 ↗
73. Yah CS, Simate GS, Iyuke SE (2012) Nanoparticles toxicity and their routes of exposures. Pak J Pharm Sci 2:477–491
74. Momin J, Jayakumar C, Prajapati J (2013) Potential of nanotechnology in functional foods. Emir J Food Agric 25:10–19. https://doi.org/10.9755/ejfa.v25i1.936810.9755/ejfa.v25i1.9368 ↗
75. Li Y, Gao M, Yin LH, Xu LN, Qi Y, Sun P, Peng JY (2021) Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress. Free Radic Biol Med 169:99–109. https://doi.org/10.1016/j.freeradbiomed.2021.03.03510.1016/j.freeradbiomed.2021.03.035 ↗
76. Joshi N, Ngwenya BT, Butler IB, French CE (2015) Use of bioreporters and deletion mutants reveals ionic silver and ROS to be equally important in silver nanotoxicity. J Hazard Mater 287:51–58. https://doi.org/10.1016/j.jhazmat.2014.12.06610.1016/j.jhazmat.2014.12.066 ↗
77. Miethling-Graff R, Rumpker R, Richter M, Verano-Braga T, Kjeldsen F, Brewer J, Hoyland J, Rubahn HG, Erdmann H (2014) Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol in Vitro 7:1280–1289. https://doi.org/10.1016/j.tiv.2014.06.00510.1016/j.tiv.2014.06.005 ↗
78. Meng X, Abdlli N, Wang N, Lu P, Nie Z, Dong X, Lu S, Chen K (2017) Effects of Ag nanoparticles on growth and fat body proteins in silkworms (Bombyx mori). Biol Trace Elem Res 2:327–337. https://doi.org/10.1007/s12011-017-1001-710.1007/s12011-017-1001-7 ↗
79. Adeel M, Shakoor N, Hussain T, Azeem I, Zhou P, Zhang P, Hao Y, Rinklebe J, Rui Y (2021) Bio-interaction of nano and bulk lanthanum and ytterbium oxides in soil system: biochemical, genetic, and histopathological effects on Eisenia fetida. J Hazard Mater 415:125574. https://doi.org/10.1016/j.jhazmat.2021.12557410.1016/j.jhazmat.2021.125574 ↗
80. Mao BH, Chen ZY, Wang YJ, Yan SJ (2018) Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Sci Rep 1:2445. https://doi.org/10.1038/s41598-018-20728-z10.1038/s41598-018-20728-z ↗
81. Ong C, Lee QY, Cai Y, Liu X, Ding J, Yung LY, Bay BH, Baeg GH (2016) Silver nanoparticles disrupt germline stem cell maintenance in the Drosophila testis. Sci Rep 6:20632. https://doi.org/10.1038/srep2063210.1038/srep20632 ↗
82. Faizan M, Faraz A, Mir AR, Hayat S (2020) Role of zinc oxide nanoparticles in countering negative effects generated by cadmium in lycopersicon esculentum. J Plant Growth Regul 1:101–115. https://doi.org/10.1007/s00344-019-10059-210.1007/s00344-019-10059-2 ↗
83. Hossain Z, Mustafa G, Komatsu S (2015) Plant responses to nanoparticle stress. Int J Mol Sci 11:26644–26653. https://doi.org/10.3390/ijms16112598010.3390/ijms161125980 ↗
84. Yang J, Cao W, Rui Y (2017) Interactions between nanoparticles and plants: phytotoxicity and defense mechanisms. J Plant Interact 1:158–169. https://doi.org/10.1080/17429145.2017.131094410.1080/17429145.2017.1310944 ↗
85. Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY (2009) Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol in Vitro 6:1076–1084. https://doi.org/10.1016/j.tiv.2009.06.00110.1016/j.tiv.2009.06.001 ↗
86. Yuan L, Richardson CJ, Ho M, Willis CW, Colman BP, Wiesner MR (2018) Stress responses of aquatic plants to silver nanoparticles. Environ Sci Technol 5:2558–2565. https://doi.org/10.1021/acs.est.7b0583710.1021/acs.est.7b05837 ↗
87. Carlson C, Hussain SM, Schrand AM, K Braydich-Stolle L, Hess KL, Jones RL, Schlager JJ (2008) Unique cellular interaction of silver nanoparticles: size-dependent generation of reactive oxygen species. J Phys Chem B 43:1360810.1021/jp712087m ↗
88. Zhou H, Zhao K, Li W, Yang N, Liu Y, Chen C, Wei T (2012) The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-kappaB-related signaling pathways. Biomaterials 29:6933–6942. https://doi.org/10.1016/j.biomaterials.2012.06.06410.1016/j.biomaterials.2012.06.064 ↗
89. Raj A, Shah P, Agrawal N (2017) Dose-dependent effect of silver nanoparticles (AgNPs) on fertility and survival of Drosophila: An in-vivo study. PLoS One 5:e0178051. https://doi.org/10.1371/journal.pone.017805110.1371/journal.pone.0178051 ↗
90. Small T, Ochoa-Zapater MA, Gallello G, Ribera A, Romero FM, Torreblanca A, Garcera MD (2016) Gold-nanoparticles ingestion disrupts reproduction and development in the German cockroach. Sci Total Environ 565:882–888. https://doi.org/10.1016/j.scitotenv.2016.02.03210.1016/j.scitotenv.2016.02.032 ↗
91. Chen H, Wang B, Feng W, Du W, Ouyang H, Chai Z, Bi X (2015) Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence. Nanotoxicology 3:302–312. https://doi.org/10.3109/17435390.2014.92918910.3109/17435390.2014.929189 ↗
92. Van NL, Ma C, Shang J, Rui Y, Liu S, Xing B (2016) Effects of CuO nanoparticles on insecticidal activity and phytotoxicity in conventional and transgenic cotton. Chemosphere 144:661–670. https://doi.org/10.1016/j.chemosphere.2015.09.02810.1016/j.chemosphere.2015.09.028 ↗
93. Deng C, Wang Y, Cota-Ruiz K, Reyes A, Sun Y, Peralta-Videa J, Hernandez-Viezcas JA, Turley RS, Niu G, Li C, Gardea-Torresdey J (2020) Bok choy (Brassica rapa) grown in copper oxide nanoparticles-amended soils exhibits toxicity in a phenotype-dependent manner: Translocation, biodistribution and nutritional disturbance. J Hazard Mater 398:122978. https://doi.org/10.1016/j.jhazmat.2020.12297810.1016/j.jhazmat.2020.122978 ↗
94. Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR (2009) Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Publ Group 4:634–641
95. Grillo R, Abhilash PC, Fraceto LF (2016) Nanotechnology applied to bio-encapsulation of pesticides. J Nanosci Nanotechnol 1:1231–1234. https://doi.org/10.1166/jnn.2016.1233210.1166/jnn.2016.12332 ↗
96. Singh A, Dhiman N, Kar AK, Singh D, Purohit MP, Ghosh D, Patnaik S (2020) Advances in controlled release pesticide formulations: prospects to safer integrated pest management and sustainable agriculture. J Hazard Mater 385:121525. https://doi.org/10.1016/j.jhazmat.2019.12152510.1016/j.jhazmat.2019.121525 ↗
97. Elmer W, De La Torre-Roche R, Pagano L, Majumdar S, Zuverza-Mena N, Dimkpa C, Gardea-Torresdey J, White JC (2018) Effect of metalloid and metal oxide nanoparticles on fusarium wilt of watermelon. Plant Dis 7:1394–1401. https://doi.org/10.1094/PDIS-10-17-1621-RE10.1094/PDIS-10-17-1621-RE ↗
98. Camara MC, Campos EVR, Monteiro RA, do Espirito Santo Pereira A, de Freitas Proenca PL, Fraceto LF (2019) Development of stimuli-responsive nano-based pesticides: emerging opportunities for agriculture. J Nanobiotechnology 1:100. https://doi.org/10.1186/s12951-019-0533-810.1186/s12951-019-0533-8 ↗
99. Kumar S, Nehra M, Dilbaghi N, Marrazza G, Hassan AA, Kim KH (2019) Nano-based smart pesticide formulations: emerging opportunities for agriculture. J Control Release 294:131–153. https://doi.org/10.1016/j.jconrel.2018.12.01210.1016/j.jconrel.2018.12.012 ↗
100. Usman M, Farooq M, Wakeel A, Nawaz A, Cheema SA, Rehman HU, Ashraf I, Sanaullah M (2020) Nanotechnology in agriculture: current status, challenges and future opportunities. Sci Total Environ 721:137778. https://doi.org/10.1016/j.scitotenv.2020.13777810.1016/j.scitotenv.2020.137778 ↗