Pharmaceutical nanotechnology: which products are been designed against COVID-19?
Source abstract
Abstract
The current pandemic COVID-19, caused by the SARS-CoV-2 virus, has been affecting thousands of people worldwide, promoting high numbers of deaths. With this, the world population is going through a process of changing habits, with social distance, improvement of hygiene techniques, to reduce the spread of the SARS-CoV-2 virus and, consequently, reduce the number of hospitalized people in serious condition, as well as the mortality rate. This scenario has been promoting a continuous search for researchers, in the most varied areas, for possible methods of prevention or cure. Specifically, in the field of pharmaceutical nanotechnology, a variety of products are being developed against SARS-CoV-2. Under these circumstances, we propose here an exposition of some of the nanotechnological products (nanoscale between 1 to 1000 nm) currently designed for the detection of the virus, for the prevention and treatment of COVID-19, in addition to equipment for personal protection. We believe that pharmaceutical nanotechnology will be a valuable tool in the disease from the development of products that guarantee our protection against the SARS-CoV-2 virus.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: SARS-CoV-2 detection and testing · Biosensors and Analytical Detection · SARS-CoV-2 and COVID-19 Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (75)
Show source-provided references
1. Abo-Zeid Y, Ismail NSM, McLean GR, Hamdy NM (2020) A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection. Eur J Pharm Sci v.153. https://doi.org/10.1016/j.ejps.2020.10546510.1016/j.ejps.2020.105465 ↗
2. Adusumilli NC, Zhang D, Friedman JM, Friedman AJ (2020) Harnessing nitric oxide for preventing limiting and treating the severe pulmonary consequences of COVID-19. Nitric Oxide 103:4–8. https://doi.org/10.1016/j.niox.2020.07.00310.1016/j.niox.2020.07.003 ↗
3. Akerstrom S, Mousavi-Jazi M, Klingstrom J, Leijon M, Lundkvist A, Mirazimi A (2005) Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. J Virol 79:1966–1969. https://doi.org/10.1128/JVI.79.3.1966-1969.200510.1128/JVI.79.3.1966-1969.2005 ↗
4. Alhazzani W, Moller MH, Arabi YM, Loed M, Gong MN, Fan E et al (2020) Surviving sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Intensive Care Med 46:854–887. https://doi.org/10.1007/s00134-020-06022-510.1007/s00134-020-06022-5 ↗
5. Astuti I, Ysrafil (2020) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an overview of viral structure and host response. 5. https://doi.org/10.1016/j.dsx.2020.04.02010.1016/j.dsx.2020.04.020 ↗
6. Chakraborty I, Maity P (2020) COVID-19 outbreak: migration, effects on society, global environment and prevention. Sci Total Environ 728. https://doi.org/10.1016/j.scitotenv.2020.13888210.1016/j.scitotenv.2020.138882 ↗
7. Chopra V, Toner E, Waldhorn R, Washer L (2020) How should U.S. hospitals prepare for coronavirus disease 2019 (COVID-19)? vol 172, p 9. https://doi.org/10.7326/M20-090710.7326/M20-0907 ↗
8. Demir GM, Degim IT. Preparation of chitosan nanoparticles by nano spray drying technology. 2013
9. Deokar AR, Nagvenkar AP, Kalt I, Shani L, Yeshurun Y, Gedanken A et al (2017) Graphene-based “Hotplate” for the capturing and destruction of the herpes simplex virus type. Bioconjug Chem 28:4. https://doi.org/10.1021/acs.bioconjchem.7b003010.1021/acs.bioconjchem.7b0030 ↗
10. Deshmukh SP, Patil SM, Mullani SB, Delekar SD (2019) Silver nanoparticles as an effective disinfectant: a review. Mat Sci Eng C-Mater 97:954–96510.1016/j.msec.2018.12.102 ↗
11. Donnelly JJ, Ulmer JB (1999) DNA vaccines for viral diseases. Braz J Med Biol Res 32(2)10.1590/S0100-879X1999000200010 ↗
12. Dorward J, Gbinigie K (2020) There is currently no strong evidence for the efficacy of lopinavir/ritonavir in the treatment of COVID-19. University of Oxford
13. Draz MS, Shafiee H (2018) Applications of gold nanoparticles in virus detection. Theranostics 8(7):1985–2017. https://doi.org/10.7150/thno.2385610.7150/thno.23856 ↗
14. Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, Brown TS, der Nigoghossian C, Zidar DA, Haythe J, Brodie D, Beckman JA, Kirtane AJ, Stone GW, Krumholz HM, Parikh SA (2020) Cardiovascular considerations for patients, health care workers, and health systems during the COVID-19 pandemic. J Am Coll Cardiol 75(18):2352–2371. https://doi.org/10.1016/j.jacc.2020.03.03110.1016/j.jacc.2020.03.031 ↗
15. Druce J, Garcia K, Tran T, Papadakis G, Birch C (2012) Evaluation of swabs, transport media, and specimen transport conditions for optimal detection of viruses by PCR. J Clin Microbiol 50(3):1064–1065. https://doi.org/10.1128/JCM.06551-1110.1128/JCM.06551-11 ↗
16. Dung TTN, Nam VN, Nhan TT, Ngoc TTB, Minh LQ, Nga BTT, Le VP, Quang DV (2020) Silver nanoparticles as potential antiviral agents against African swine fever virus. Mater Res Express 6:12
17. Durán N, Marcato PD, Conti RD, Alves OL, Costa FTM, Brocchi M (2010) Potential use of silver nanoparticles on pathogenic bacteria, their toxicity and possible mechanisms of action. J Braz Chem Soc 21:6. https://doi.org/10.1590/S0103-5053201000060000210.1590/S0103-50532010000600002 ↗
18. Entos Pharma. The challenge: effective drug delivery. 2020. Available in: https://www.entospharma.com/fusogenix.
19. Erdmann VA, Barciszewski J (2013) DNA and RNA nanobiotechnologies in medicine: diagnosis and treatment of diseases. Springer Science & Business Media, Berlin10.1007/978-3-642-36853-0 ↗
20. FDA – Food and Drug Administration. Guidance for industry considering whether an FDA-regulated product involves the application of nanotechnology. 2014
21. Giwa A, Desai A, Duca A. Novel 2019 coronavirus SARS-CoV-2 (COVID-19): na overview for emergency clinicians. Emerg. Med. Pract., 2020
22. Grenha A, Seijo B, Remuñán-López C (2005) Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 25:427–43710.1016/j.ejps.2005.04.009 ↗
23. Hamdy ME, Carlo MD, Hussein HA, Salah TA, El-Deeb AH, Emara MM, Pezzoni G, Compagnone D (2018) Development of gold nanoparticles biosensor for ultrasensitive diagnosis of foot and mouth disease virus. J Nanobiotechnology 16:48. https://doi.org/10.1186/s12951-018-0374-x10.1186/s12951-018-0374-x ↗
24. He X, Hwang HM (2016) Nanotechnology in food science: functionality, applicability, and safety assessment. J Food Drug Anal 24(4):671–681. https://doi.org/10.1016/j.jfda.2016.06.00110.1016/j.jfda.2016.06.001 ↗
25. Holzinger M, Goff AL, Cosnier S (2014) Nanomaterials for biosensing applications: a review. Front Chem 2. https://doi.org/10.3389/fchem.2014.0006310.3389/fchem.2014.00063 ↗
26. Islam N, Ferro V (2016) Recent advances in chitosan-based nanoparticles pulmonary drug delivery. Nanoscale 8(30):14341–1435810.1039/C6NR03256G ↗
27. Itani R, Tobaiqy M, Faraj AA (2020) Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients. Theranostics 10(13):5932–5942. https://doi.org/10.7150/thno.4669110.7150/thno.46691 ↗
28. Jampilek J, Kos J, Kralova K (2019) Potential of nanomaterial applications in dietary supplements and foods for special medical purposes. Nanomaterials (Basel) 9:2. https://doi.org/10.3390/nano902029610.3390/nano9020296 ↗
29. Jeevanandam J, Barhoum A, Chan YS, Dufresne A, Danquah MK (2018) Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations. Beilstein J Nanotechnol 9:1050–1074. https://doi.org/10.3762/bjnano.9.9810.3762/bjnano.9.98 ↗
30. Kaczmarek JC, Kowalski PS, Anderson DG (2017) Advances in the delivery of RNA therapeutics: from concept to clinical reality. Genome Med 9. https://doi.org/10.1186/s13073-017-0450-010.1186/s13073-017-0450-0 ↗
31. Khan I, Saeed K, Khan I (2019) Nanoparticles: properties, applications and toxicities. Arab J Chem 12(7):908–931. https://doi.org/10.1016/j.arabjc.2017.05.01110.1016/j.arabjc.2017.05.011 ↗
32. King T, Osmond-McLeod MJ, Duffy LL (2018) Nanotechnology in the food sector and potential applications for the poultry industry. Trends Food Sci Technol 72:62–73. https://doi.org/10.1016/j.tifs.2017.11.01510.1016/j.tifs.2017.11.015 ↗
33. Kissler SM, Tedijanto C, Goldstein E, Grad YH, Lipsitch M (2020) Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period. Science 368:860–868. https://doi.org/10.1126/science.abb579310.1126/science.abb5793 ↗
34. Lee NY, Ko WC, Hsueh PR (2019) Nanoparticles in the treatment of infections caused by muldidrug-resistant organisms. Front Pharmacol 10. https://doi.org/10.3389/fphar.2019.0115310.3389/fphar.2019.01153 ↗
35. Li H, Liu SM, Yu XH, Tang SL, Tang CK (2020a) Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents 55:5. https://doi.org/10.1016/j.ijantimicag.2020.10595110.1016/j.ijantimicag.2020.105951 ↗
36. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, Pan P, Wang W, Hu D, Liu X, Zhang Q, Wu J (2020b) Coronavirus infections and immune responses. J Med Virol 92:424–432. https://doi.org/10.1002/jmv.2568510.1002/jmv.25685 ↗
37. Li Z, Yi Y, Luo X, Xiong N, Liu Y, Li S, Sun R, Wang Y, Hu B, Chen W, Zhang Y, Wang J, Huang B, Lin Y, Yang J, Cai W, Wang X, Cheng J, Chen Z, Sun K, Pan W, Zhan Z, Chen L, Ye F (2020c) Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. J Med Virol 92:1518–1524. https://doi.org/10.1002/jmv.2572710.1002/jmv.25727 ↗
38. Lombardo D, Kiselev MA, Caccamo MT (2019) Smart nanoparticles for drug delivery application: development of versatile nanocarrier platforms in biotechnology and nanomedicine. J Nanomater 2019:1–26. https://doi.org/10.1155/2019/370251810.1155/2019/3702518 ↗
39. Lustig SR, Biswakarma JJH, Rana D, Tilford SH, Hu W, Su M, Rosenblatt MS (2020) Effectiveness of common fabrics to block aqueous aerosols of virus-like nanoparticles. ACS Nano 14(6):7651–7658. https://doi.org/10.1021/acsnano.0c0397210.1021/acsnano.0c03972 ↗
40. Mackenzie JS, Smith DW. COVID-19: a novel zoonotic disease caused by a coronavirus from China: what we know and what we don’t. Microbiol Aust, v.17, 2020. https://doi.org/10.1071/MA2001310.1071/MA20013 ↗
41. Malekzad H, Zangabad PS, Mirshekari H, Karimi M, Hamblin MR (2017) Noble metal nanoparticles in biosensors: recent studies and applications. Nanotechnol Rev 6(3):301–329. https://doi.org/10.1515/ntrev-2016-001410.1515/ntrev-2016-0014 ↗
42. Marassi V, Cristo LD, Smith SGJ, Ortelli S, Blosi M, Costa AL, Reschiglian P, Volkov Y, Prina-Mello A. Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents. R Soc Open Sci, v.5, n.1, 2018. https://doi.org/10.1098/rsos.17111310.1098/rsos.171113 ↗
43. Mehra MR, Desai SS, Ruschitzka F, Patel AN (2020) Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis. Lancet. https://doi.org/10.1016/S0140-6736(20)31180-610.1016/S0140-6736(20)31180-6 ↗
44. Melo A, Amadeu MS, Lancellotti M, Hollanda LM, Machado D. The role of nanomaterials in cosmetics: national and international legislative aspects. Quim. Nova, v.38, n.4, 2015. https://doi.org/10.5935/0100-4042.2015004210.5935/0100-4042.20150042 ↗
45. Mohammed MA, Syeda JTM, Wasan KM, Wasan EK. An overview of chitosan nanoparticles and its application in non-parenteral drug delivery. Pharmaceutics, v.9, n.4, 2017. https://doi.org/10.3390/pharmaceutics9040005310.3390/pharmaceutics90400053 ↗
46. Monteiro WM, Brito-Sousa JD, Baía-da-Silva D, Melo GC, Siqueira AM, Val F et al. Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes. Rev. Soc. Bras. Med. Trop., v.53, 2020. https://doi.org/10.1590/0037-8682-0155-202010.1590/0037-8682-0155-2020 ↗
47. Nanotechnology Products Database. COVID-19. 2020. Available in: https://product.statnano.com/.
48. Novochizol. Aerosol formulation of COVID-19. 2020. Available in: https://www.novochizol.ch/.
49. Oliveira AC, Lucas TC, Iquiapaza RA. What has the COVID-19 pandemic taught us about adopting preventive measures? Texto Contexto, v.29, 2019. https://doi.org/10.1590/1980-265x-tce-2020-010610.1590/1980-265x-tce-2020-0106 ↗
50. Oliveira TC, Abranches MV, Lana RM. Food (in)security in Brazil in the contexto of the SARS-CoV-2 pandemic. Cad. Saúde Pública, v.36, n.4, 2020. https://doi.org/10.1590/0102-311x0005522010.1590/0102-311x00055220 ↗
51. Palmieri V, Papi M. Can graphene take part in the fight against COVID-19? Nano Today, v.33, 2020. https://doi.org/10.1016/j.nantod.2020.10088310.1016/j.nantod.2020.100883 ↗
52. Peng Y, Chen L, Ye S, Kang Y, Liu J, Zeng S, Yu L (2020) Research and development of drug delivery systems based on drug transporter and nanoformulation. Asian J Pharm Sci 15(2):220–236. https://doi.org/10.1016/j.ajps.2020.02.00410.1016/j.ajps.2020.02.004 ↗
53. Pourshahab PS, Gilani K, Moazeni E, Eslahi H, Fazeli MR, Jamalifar H (2011) Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid. J Microencapsul 28(7):605–613. https://doi.org/10.3109/02652048.2011.59943710.3109/02652048.2011.599437 ↗
54. Qiu G, Gai Z, Tao Y, Schmitt J, Kullak-Ublick GA, Wang J (2020) Dual-functional plasmonic photothermal biosensors for highly accurate severe acute respiratory syndrome coronavirus 2 detection. ACS Nano 14(5):5268–5277. https://doi.org/10.1021/acsnano.0c0243910.1021/acsnano.0c02439 ↗
55. Sanders JM, Monogue ML, Jodlowski TZ (2020) Pharmacologic treatments for coronavirus disease 2019 (COVID-19) a review. JAMA 323(18):1824–1836. https://doi.org/10.1001/jama.2020.601910.1001/jama.2020.6019 ↗
56. Saylor K, Gillam F, Lohneis T, Zhang C (2020) Designs of antigen structure and composition for improved protein-based vaccine efficacy. Front Immunol 11. https://doi.org/10.3389/fimmu.2020.0028310.3389/fimmu.2020.00283 ↗
57. Simbine EO, Rodrigues LC, Lapa-Guimarães J, Kamimura ES, Corassin CH, Oliveira CAF (2019) Application of silver nanoparticles in food packages: a review. Food Sci Technol 39:4. https://doi.org/10.1590/fst.3631810.1590/fst.36318 ↗
58. Singh T, Shukla S, Kumar P, Wahla V, Bajpai VK, Rather IA. Application of nanotechnology in food science: perception and overview. Front Microbiol., v.8, 2017. https://doi.org/10.3389/fmicb.2017.0150110.3389/fmicb.2017.01501 ↗
59. Singh AK, Singh A, Shaikh A, Singh R, Misra A (2020) Chloroquine and hydroxychloroquine in the treatment of COVID-19 with or without diabetes: a systematic search and a narrative review with a special reference to India and other developing countries. Diabetes Metab Syndr 14(3):241–246. https://doi.org/10.1016/j.dsx.2020.03.01110.1016/j.dsx.2020.03.011 ↗
60. Tang A, Tong ZD, Wang HL, Dai YX, Li KF, Liu JN, Wu WJ, Yuan C, Yu ML, Li P, Yan JB (2020) Detection of novel coronavirus by RT-PCR in stool specimen from asymptomatic child, China. Emerg Infect Dis 26(6):1337–1339. https://doi.org/10.3201/eid2606.20030110.3201/eid2606.200301 ↗
61. Udugama B, Kadhiresan P, Kozlowski HN, Malekjahani A, Osborne M, Li VYC, Chen H, Mubareka S, Gubbay JB, Chan WCW (2020) Diagnosing COVID-19: the disease and tools for detection. ACS Nano 14:3822–3835. https://doi.org/10.1021/acsnano.0c0262410.1021/acsnano.0c02624 ↗
62. Wang X, Sun W, Yang W, Gao S, Sun C, Li Q (2019) Mesoporous silica-protected silver nanoparticle disinfectant with controlled Ag+ ion release, efficient magnetic separation, and effective antibacterial activity. Nanoscale Adv 1:840–84810.1039/C8NA00275D ↗
63. Ways TMM, Lau WM, Khutoryanskiy VV. Chitosan and its derivatives for application in mucoadhesive drug delivery systems. Polymers, v.10, n.3, 2018. https://doi.org/10.3390/polym1003026710.3390/polym10030267 ↗
64. Wei Y, Huang YH, Cheng KC, Song YL. Investigations of the influences of processing conditions on the properties of spray dried chitosan-tripolyphosphate particles loaded with theophylline. Scientific Reports, v.10, 2020. https://doi.org/10.1038/s41598-020-58184-310.1038/s41598-020-58184-3 ↗
65. Weiss C, Carriere M, Fusco L, Capua I, Regla-Nava JA, Pasquali M, Scott JA, Vitale F, Unal MA, Mattevi C, Bedognetti D, Merkoçi A, Tasciotti E, Yilmazer A, Gogotsi Y, Stellacci F, Delogu LG (2020) Toward nanotechnology-enabled approaches against the COVID-19 pandemic. ACS Nano 14(6):6383–6406. https://doi.org/10.1021/acsnano.0c0369710.1021/acsnano.0c03697 ↗
66. WHO. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 84. 2020a. Available in: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
67. WHO. World Health Organization. Water, sanitation, hygiene, and waste management for the COVID-19 virus: interim guidance. 2020b
68. Yang XX, Li CM, Li YF, Wang J, Huang CZ (2017) Synergistic antiviral effect of curcumin functionalized graphene oxide against respiratory syncytial virus infection. Nanoscale 9:16086–16092. https://doi.org/10.1039/c7nr06520e10.1039/c7nr06520e ↗
69. Youssef FS, El-Banna HA, Elzorba HY, Galal AM (2019) Application of some nanoparticles in the field of veterinary medicine. Int J Vet Sci Med 7(1):78–93. https://doi.org/10.1080/23144599.2019.169137910.1080/23144599.2019.1691379 ↗
70. Zhang Q, Honko A, Zhou J, Gong H, Downs SN, Vaques JH et al (2020) Cellular nanosponges inhibit SARS-CoV-2 infectivity. Nano Lett 20(7):5570–5574. https://doi.org/10.1021/acs.nanolett.0c0227810.1021/acs.nanolett.0c02278 ↗
71. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, Wang X, Yuan J, Li T, Li J, Qian S, Hong C, Wang F, Liu Y, Wang Z, He Q, Li Z, He B, Zhang T, Fu Y, Ge S, Liu L, Zhang J, Xia N, Zhang Z (2020) Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. Clin Infect Dis. https://doi.org/10.1093/cid/ciaa34410.1093/cid/ciaa344 ↗
72. Zhu X, Wang X, Han L, Chen T, Wang L, Li H et al. Multiplex reverse transcription loop-mediated isothermal amplification combined with nanoparticle-based lateral flow biosensor for the diagnosis of COVID-19. Biosens. Bioelectron., v.166, 2020. https://doi.org/10.1016/j.bios.2020.11243710.1016/j.bios.2020.112437 ↗
73. Ziem B, Thien H, Achazi K, Yue C, Stern D, Silberreis K, Gholami MF, Beckert F, Gröger D, Mülhaupt R, Rabe JP, Nitsche A, Haag R (2016) Hidhly efficient multivalent 2D nanosystems for inhibition of orthopoxvirus particles. Adv Healthc Mater 5:2922–2930. https://doi.org/10.1002/adhm.20160081210.1002/adhm.201600812 ↗
74. Ziem B, Azab W, Gholami MF, Rabe JP, Osterrieder N, Haag R (2017) Size-dependent inhibition of herpesvirus cellular entry by polyvalent nanoarchitectures. Nanoscale 9:3774–3783. https://doi.org/10.1039/c7nr00611j10.1039/c7nr00611j ↗
75. Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, Wan Y, Chung A, Cheung CP, Chen N, Lai CKC, Chen Z, Tso EYK, Fung KSC, Chan V, Ling L, Joynt G, Hui DSC, Chan FKL, Chan PKS, Ng SC (2020) Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.05.04810.1053/j.gastro.2020.05.048 ↗