Study of 223Ra uptake mechanism by Fe3O4 nanoparticles: towards new prospective theranostic SPIONs
Source abstract
Abstract
The use of superparamagnetic iron oxide nanoparticles (SPIONs) and radiolabelled nanoparticles (NPs) has grown considerably over the recent years, and the SPIONs labelled with medicinal radionuclides offer new opportunities in multimodal diagnostics and in the drug-delivery systems for targeted alpha-particle therapy (TAT) driven by magnetic field gradient or by biologically active moieties bound on NPs shell. However, the mechanisms of NPs radiolabelling are not studied substantially and still remain unclear, even though the way of label attachment directly implies the stability of the label-nanoparticle construct. Since the 223Ra was the first clinically approved alpha-emitter, it is a promising nuclide for further development of its targeted carriers. We report here on the study of 223Ra uptake by the Fe3O4 SPIONs, together with an attempt to propose the 223Ra uptake mechanism by the Fe3O4 NPs in the presence of a phosphate buffer a typical formulation medium, under the pseudo-equilibrium conditions. Further, the in vitro stability tests of the prepared [223Ra]Fe3O4 NPs were performed to estimate the 223Ra label stability. The potential use of 223Ra-labelled SPIONs in theranostic applications is also discussed.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Radiation Therapy and Dosimetry · Radiopharmaceutical Chemistry and Applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Alexiou C, Jurgons R, Schmid RJ, Bergemann C, Henke J, Erhardt W, Huenges E, Parak F (2003) Magnetic drug targeting—biodistribution of the magnetic carrier and the chemotherapeutic agent mitoxantrone after locoregional cancer treatment. J Drug Targ 11(3):139–14910.3109/1061186031000150791 ↗
2. Ames LL, McGarrah JE, Walker BA, Salter PF (1983) Uranium and radium sorption on amorphous ferric oxyhydroxide. Chem Geol 40(1–2):135–14810.1016/0009-2541(83)90095-5 ↗
3. Arruebo M, Fernández-Pacheco R, Ibarra MR, Santamaría J (2007) Magnetic nanoparticles for drug delivery. Nano Today 2(3):22–3210.1016/S1748-0132(07)70084-1 ↗
4. Bayer Pharma AG (2016) Xofigo® - Summary of product characteristics. http://www.xofigo.com/omr/online/Xofigo_SMPC.pdf . Accessed 1 May 2016
5. Burke BP, Baghdadi N, Clemente GS, Camus N, Guillou A, Kownacka AE, Domarkas J, Halime Z, Tripier R, Archibald SJ (2014) Final step gallium-68 radiolabelling of silica-coated iron oxide nanorods as potential PET/MR multimodal imaging agents. Faraday Discuss 175:59–71
6. Bychkova AV, Sorokina ON, Rosenfeld MA, Kovarski AL (2015) Multifunctional biocompatible coatings on magnetic nanoparticles. Russ Chem Rev 81(11):1026–105010.1070/RC2012v081n11ABEH004280 ↗
7. Devaraj NK, Keliher EJ, Thurber GM, Nahrendorf M, Weissleder R (2009) 18F labeled nanoparticles for in vivo PET-CT imaging. Bioconjug Chem 20(2):397–40110.1021/bc8004649 ↗
8. Dvořák L, Ledvinka T, Sobotka M (1991) FAMULUS 3.1, Computer equipment, Prague
9. Filipská H, Štamberg K (2005) Mathematical modeling of a Cs(I)—Sr(II)—bentonite—magnetite sorption system, simulating the processes taking place in a deep geological repository. Acta Polytech 45(5):11–1810.14311/758 ↗
10. Filipská H, Štamberg K (2006) Sorption of Cs(I) and Sr(II) on a mixture of bentonite and magnetite using SCM + IExM: a parametric study. J Radioanal Nucl Chem 270(3):531–54210.1007/s10967-006-0459-0 ↗
11. Gonneea ME, Morris PJ, Dulaiova H, Charette MA (2008) New perspectives on radium behavior within a subterranean estuary. Mar Chem 109(3–4):250–26710.1016/j.marchem.2007.12.002 ↗
12. Grazulis S, Chateigner D, Downs RT, Yokochi AT, Quiros M, Lutterotti L, Manakova E, Butkus J, Moeck P, Le Bail A (2009) Crystallography Open Database—an open-access collection of crystal structures. J Appl Crystallogr 42:726–72910.1107/S0021889809016690 ↗
13. Guseva LI, Tikhomirova GS, Dogadkin NN (2004) Separation of radium from alkaline-earth metals and actinides in aqueous-methanol solutions of HNO3. 227Ac-223Ra generator. Radiochemistry 46(1):58–6210.1023/B:RACH.0000024637.39523.e4 ↗
14. Herbelin AL, Westall JC (1996) FITEQL—a computer program for determination of chemical equilibrium constants from experimental data. Version 3.2, Report 96-01. Department of Chemistry, Oregon State University, Corvallis, Oregon, USA
15. Hoffman D, Sun M, Yang L, McDonagh PR, Corwin F, Sundaresan G, Wang L, Vijayaragavan V, Thadigiri C (2014) Intrinsically radiolabelled [59Fe]-SPIONs for dual MRI/radionuclide detection. Am J Nucl Med Mol Imag 4(6):548–560
16. Kirby HW, Salutsky ML, Grace WR (1964) The radiochemistry of radium. Springfield, Virginia
17. Kozempel J, Vlk M (2014) Nanoconstructs in targeted alpha-therapy. Curr Nanomed 4(2):71–76. doi: 10.2174/187791230566615010200054910.2174/1877912305666150102000549 ↗
18. Kozempel J, Vlk M, Málková E, Bajzíková A, Bárta J, Santos-Oliveira R, Malta Rossi A (2015) Prospective carriers of 223Ra for targeted alpha particle therapy. J Radioanal Nucl Chem 304(1):443–44710.1007/s10967-014-3615-y ↗
19. Kraus W, Nolze G (1996) POWDER CELL—a program for the representation and manipulation of crystal structures and calculation of the resulting X-ray powder patterns. J Appl Crystallogr 29:301–30310.1107/S0021889895014920 ↗
20. Kroupová H (2004) Studies of sorption interactions in system: Bentonite—selected radionuclides and container corrosion products—underground water. Doctoral Thesis. Prague, Czech Technical University, Department of Nuclear Chemistry
21. Lábár JL (2005) Consistent indexing of a (set of) single crystal SAED pattern(s) with the ProcessDiffraction. Ultramicroscopy 103:237–24910.1016/j.ultramic.2004.12.004 ↗
22. Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations and biological applications. Chem Rev 108(6):2064–211010.1021/cr068445e ↗
23. Li W-P, Liao P-Y, Su C-H, Yeh C-S (2014) Formation of oligonucleotides-gated silica shell-coated Fe3O4-Au core-shell nanotrisoctahedra for magnetically targeted and near-infrared light responsive theranostic platform. J Am Chem Soc 136(28):10062–1007510.1021/ja504118q ↗
24. Ma M, Zhang Y, Yu W, Shen H, Zhang H, Gu N (2003) Preparation and characterization of magnetite nanoparticles coated by amino silane. Colloid Surf A 212:219–22610.1016/S0927-7757(02)00305-9 ↗
25. Mody VV, Cox A, Shah S, Singh A, Bevins W, Parihar H (2014) Magnetic nanoparticle drug delivery systems for targeting tumor. Appl Nanosci 4:385–39210.1007/s13204-013-0216-y ↗
26. Mokhodoeva O, Guseva L, Dogadkin N (2015) Isolation of generator-produced Ra-223 in 0.9% NaCl solutions containing EDTA for direct radiotherapeutic studies. J Radioanal Nucl Chem 304(1):449–45310.1007/s10967-014-3777-7 ↗
27. Nallathamby PD, Mortensen NP, Palko HA, Malfatti M, Smith C, Sonnett J, Doktycz MJ, Gu BH, Roeder RK, Wang W, Retterer ST (2015) New surface radiolabeling schemes of super paramagnetic iron oxide nanoparticles (SPIONs) for biodistribution studies. Nanoscale 7(15):6545–655510.1039/C4NR06441K ↗
28. Nilsson S, Larsen RH, Foss SD, Balteskard L, Borch KW, Westlin J-E, Salberg G, Bruland ØS (2005) Clin Cancer Res 11(12):4451–445910.1158/1078-0432.CCR-04-2244 ↗
29. OECD-NEA (2016) ZZ-HATCHES-20, Database for radiochemical modelling. https://www.oecd-nea.org/tools/abstract/detail/nea-1210 . Accessed 1 May 2016
30. Park J, Kadasala NR, Abouelmagd SA, Castanares MA, Collins DS, Wei A, Yeo Y (2016) Polymer-iron oxide composite nanoparticles for EPR-independent drug delivery. Biomaterials 101:285–29510.1016/j.biomaterials.2016.06.007 ↗
31. Piotrowska A, Leszczuk E, Bruchertseifer F, Morgenstern A, Bilewicz A (2013) Functionalized NaA nanozeolites labeled with Ra-224, Ra-225 for targeted alpha therapy. J Nanopart Res 15:2082. doi: 10.1007/s11051-013-2082-710.1007/s11051-013-2082-7 ↗
32. Reddy LH, Arias JL, Nicolas J, Couvreur P (2012) Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications. Chem Rev 112(11):5818–587810.1021/cr300068p ↗
33. Sajih M, Bryan ND, Livens FR, Vaughan DJ, Descostes M, Phrommavanh V, Nos J, Morris K (2014) Adsorption of radium and barium on goethite and ferrihydrite: a kinetic and surface complexation modelling study. Geochim Cosmochim Ac 146:150–16310.1016/j.gca.2014.10.008 ↗
34. Schneider CA, Rasband WS, Eliceiri KW (2012) NIH image to imageJ: 25 years of image analysis. Nat Methods 9:671–67510.1038/nmeth.2089 ↗
35. Shore ND (2015) Radium-223 dichloride for metastatic castration-resistant prostate cancer: the urologist’s perspective. Urology 85(4):717–72410.1016/j.urology.2014.11.031 ↗
36. Singh N, Jenkins GJS, Asadi R, Doak SH (2010) Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION). Nano Rev 1:5358. doi: 10.3402/nano.v1i0.535810.3402/nano.v1i0.5358 ↗
37. Slouf M, Ostafinska A, Nevoralova M, Fortelny I (2015) Morphological analysis of polymer systems with broad particle size distribution. Polym Test 42:8–1610.1016/j.polymertesting.2014.12.012 ↗
38. Tsiapa I, Efthimiadou EK, Fragogeorgi E, Loudos G, Varvarigou AD, Bouziotis P, Kordas GC, Mihailidis D, Nikiforidis GC, Xanthopoulos S, Psimadas D, Paravatou-Petsotas M, Palamaris L, Hazle JD, Kagadis GC (2014) (99 m)Tc-labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of ανβ3-mediated tumor expression and feasibility for hyperthermia treatment. J Colloid Interf Sci 433:163–17510.1016/j.jcis.2014.07.032 ↗
39. Waldron RD (1955) Infrared spectra of ferrites. Phys Rev 99:1727–172910.1103/PhysRev.99.1727 ↗
40. Wang G, de Kruijff RM, Rol A, Thijssen L, Mendes E, Morgenstern A, Bruchertseifer F, Stuart MCA, Wolterbeek HT, Denkova AG (2014) Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles. Appl Radiat Isot 85:45–5310.1016/j.apradiso.2013.12.008 ↗
41. Woodward J, Kennel SJ, Stuckey A, Osborne D, Wall J, Rondinone AJ, Standaert RF, Mirzadeh S (2011) LaPO4 nanoparticles doped with actinium-225 that partially sequester daughter radionuclides. Bioconjug Chem 22(4):766–77610.1021/bc100574f ↗
42. Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H, Li J, Chen K, Zhang H, Cheng Z (2013) Affibody modified and radiolabeled gold-iron oxide hetero-nanostructures for tumor PET, optical and MR imaging. Biomaterials 34(11):2796–280610.1016/j.biomaterials.2013.01.014 ↗