Antibacterial endotracheal tube with silver-containing double-network hydrogel coating
Source abstract
Abstract
In this study, a double-network hydrogel coating with silver loading was developed for antibacterial catheters using an in-situ photoinitiation method, a stepwise immersion process, and ion exchange. The silver-loading capacity, release kinetics, and in vitro antibacterial performance of the coatings were assessed. Furthermore, a silver-loaded coating was prepared on commercially available endotracheal tubes and its anti-infection capabilities were investigated using a rabbit tracheal intubation model. The results showed that [email protected]+ exhibited a uniform and stable dispersion of silver ions (Ag+), controllable silver loading capacity, and effective Ag+ release. The coating also exhibited excellent in vitro antibacterial performance against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P. aeruginosa). In vivo studies demonstrated a significant reduction in tracheal intubation-related pulmonary infections. Silver-loaded hydrogel coatings have potential applications in the development of antibacterial catheters for preventing healthcare-associated infections.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nosocomial Infections in ICU · Inhalation and Respiratory Drug Delivery · Airway Management and Intubation Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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