Influence of glutathione responsive tumor-targeted camptothecin nanoparticles on glioma based on oxidative stress
Source abstract
Abstract
Abstract Glioma is the most common primary malignant tumor of central nervous system and has a close relationship with oxidative stress. A novel glutathione (GSH) responsive camptothecin nanoparticle (CPT-SS-mPEG2000 micelle) was synthesized and prepared. CPT-SS-mPEG2000 micelles had better stability of particle size at room temperature and exhibited obvious glutathione responsive effect. The results of apoptosis and HE staining showed that tumor cells and nuclear density were significantly reduced after CPT-SS-mPEG2000 micelles treatment. At the same time, CPT-SS-mPEG2000 micelles could effectively increase the SOD content and decrease the MDA content. CPT-SS-mPEG2000 micelles have significant antioxidative ability and superior therapeutic effect on brain glioma.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Dendrimers and Hyperbranched Polymers
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (29)
Show source-provided references
1. Brain stem and entire spinal leptomeningeal dissemination of supratentorial glioblastoma multiforme in a patient during postoperative radiochemotherapy10.1097/MD.0000000000000962 ↗
2. Malignant gliomas in adults10.1056/NEJMra0708126 ↗
3. Tumor antigens in glioma10.1016/j.smim.2020.101385 ↗
4. A radiation-induced gene expression signature as a tool to predict acute radiotherapy-induced adverse side effects10.1016/j.canlet.2010.12.006 ↗
5. Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs10.1248/bpb.b12-01102 ↗
6. Inhibition of brain tumor growth by intravenous poly (beta-L-malic acid) nanobioconjugate with pH-dependent drug release10.1073/pnas.1003919107 ↗
7. ROS and brain gliomas: an overview of potential and innovative therapeutic strategies10.3390/ijms17060984 ↗
8. Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation10.1007/s13277-014-2644-z ↗
9. Role of epigenetics and oxidative stress in gliomagenesis10.2174/1871527317666180110124645 ↗
10. Quercetin inhibition of ROS-dependent and independent apoptosis in rat glioma C6 cells10.1016/j.tox.2006.03.007 ↗
11. Biodegradable polymeric nanoparticles based drug delivery systems10.1016/j.colsurfb.2009.09.001 ↗
12. A target-specific oral formulation of doxorubicin-protein nanoparticles: efficacy and safety in hepatocellular cancer10.7150/jca.7093 ↗
13. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs10.1038/nbt1339 ↗
14. Redox-responsive alginate nanogels with enhanced anticancer cytotoxicity10.1021/bm400768m ↗
15. Embedding of active proteins and living cells in redox-sensitive hydrogels and nanogels through enzymatic cross-linking10.1002/anie.201206266 ↗
16. Redox-sensitive and intrinsically fluorescent photoclick hyaluronic acid nanogels for traceable and targeted delivery of cytochrome c to breast tumor in mice10.1021/acsami.6b05775 ↗
17. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery10.1016/j.jconrel.2011.01.030 ↗
18. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple10.1016/S0891-5849(01)00480-4 ↗
19. Reduction-cleavable polym eric vesicles with efficient glutathione-mediated drug release behavior for reversing drug resistance10.1021/am402860v ↗
20. Biodegradable m ixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance10.2147/IJN.S111930 ↗
21. Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer10.1016/j.colsurfb.2016.12.012 ↗
22. Redox-sensitive m PEG-SS-PTX/TPGS mixed micelles: an efficient drug delivery system for overcoming multidrug resistance10.1016/j.ijpharm.2016.10.029 ↗
23. Stimuli-responsive polymers and their applications in nanomedicine10.1007/s13758-011-0009-3 ↗
24. Reactive oxygen species and cancer paradox: to promote or to suppress10.1016/j.freeradbiomed.2017.01.004 ↗
25. Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling10.1089/ars.2012.4599 ↗
26. Novel combination of salinomycin and resveratrol synergistically enhances the anti-proliferative and pro-apoptotic effects on human breast cancer cells10.1007/s10495-017-1394-y ↗
27. Synergistic anticancer effect of panobinostat and topoisomerase inhibitors through ROS generation and intrinsic apoptotic pathway induction in cervical cancer cells10.1007/s13402-017-0366-0 ↗
28. Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract10.1007/s11010-017-3254-z ↗
29. Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress10.1038/s41598-017-06535-y ↗