Cubosomes in cancer drug delivery: A review
Source abstract
Abstract
The lyotropic nonlamellar liquid crystalline nanoparticles (LCNs), especially cubosomes are gaining utility and acceptance as a drug delivery system, in diseases like cancer. These cubosomes are highly versatile carriers with promising theranostic efficiency and can be administered via oral, topical, or intravenous modalities. Over the recent years, significant research has facilitated the improvement in the efficacy, preparation, characterization, target selectivity, and controlling drug release profiles of the loaded anticancer bioactive. Nonetheless, its clinical translation has been slow and additionally requires concrete evidence. This review underscores the recent advances and impediments in the development and application of cubosomes against various cancers and discussing the hurdles faced in segueing it into a potential nanotechnological intervention.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lipid Membrane Structure and Behavior · RNA Interference and Gene Delivery · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (82)
Show source-provided references
1. A cost–benefit analysis of the physical mechanisms of membrane curvature10.1038/ncb2832 ↗
2. Membrane lipids: where they are and how they behave10.1038/nrm2330 ↗
3. Cubosomes: the next generation of smart lipid nanoparticles?10.1002/anie.201804067 ↗
4. Membrane curvature and mechanisms of dynamic cell membrane remodelling10.1038/nature04396 ↗
5. Liposomes: technologies and analytical applications10.1146/annurev.anchem.1.031207.112747 ↗
6. Lipid-based nanoparticles: application and recent advances in cancer treatment10.3390/nano9040638 ↗
7. Liposomal siRNA nanocarriers for cancer therapy10.1016/j.addr.2013.12.008 ↗
8. Lipid-based nanocarriers for cancer gene therapy
9. Lipid map of the mammalian cell10.1242/jcs.071233 ↗
10. Cubosomes: an overview10.1248/bpb.30.350 ↗
11. Cubic phases of lipid-containing systems10.1006/jmbi.1993.1053 ↗
12. Phase behavior of the phytantriol/water system10.1021/la0350812 ↗
13. Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers10.1039/c1sm05181d ↗
14. Cubosomes: structure, preparation and use as an antigen delivery system
15. Aqueous dispersions of cubic lipid–water phases10.1016/S1359-0294(00)00040-6 ↗
16. Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems10.1016/j.drudis.2019.05.004 ↗
17. Preparation and structural investigations of colloidal dispersions prepared from cubic monoglyceride–water phases10.1016/S0378-5173(02)00298-3 ↗
18. Overview of cubosomes: a nano particle
19. Dry powder precursors of cubic liquid crystalline nanoparticles (cubosomes)10.1023/A:1021184216308 ↗
20. Cubic phase nanoparticles (cubosome): principles for controlling size, structure, and stability10.1021/la047590p ↗
21. Novel process for producing cubic liquid crystalline nanoparticles (cubosomes)10.1021/la010161w ↗
22. Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: pharmaceutical, biological, and toxicological studies10.2147/IJN.S87336 ↗
23. Cancer-cell-targeted theranostic cubosomes10.1021/la501332u ↗
24. Biotinylated cubosomes: a versatile tool for active targeting and codelivery of paclitaxel and a fluorescein-based lipid dye10.1021/acs.langmuir.5b03469 ↗
25. Targeted detection of phosphatidylserine in biomimetic membranes and in vitro cell systems using annexin V-containing cubosomes10.1016/j.biomaterials.2013.07.042 ↗
26. Clickable cubosomes for antibody-free drug targeting and imaging applications10.1021/acs.bioconjchem.7b00659 ↗
27. Drug-loaded fluorescent cubosomes: versatile nanoparticles for potential theranostic applications
28. Docetaxel-loaded fluorescent liquid-crystalline nanoparticles for cancer theranostics10.1021/acs.langmuir.5b02101 ↗
29. Charged additives modify drug release rates from lipidic cubic phase carriers by modulating electrostatic interactions10.1016/j.jelechem.2017.10.057 ↗
30. The ever-increasing importance of cancer as a leading cause of premature death worldwide10.1002/cncr.33587 ↗
31. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
32. Delivery strategies for macromolecular drugs in cancer therapy10.1016/j.apsb.2020.01.009 ↗
33. Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy10.1039/D0TB00649A ↗
34. Editorial: applications of nanobiotechnology in pharmacology10.3389/fphar.2019.01451 ↗
35. A review on the effects of current chemotherapy drugs and natural agents in treating non–small cell lung cancer10.1051/bmdcn/2017070423 ↗
36. Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: the eastern cooperative oncology group results10.1093/jnci/85.5.388 ↗
37. Phase II study of taxol in patients with untreated advanced non-small-cell lung cancer10.1093/jnci/85.5.384 ↗
38. Paclitaxel-loaded self-assembled lipid nanoparticles as targeted drug delivery systems for the treatment of aggressive ovarian cancer10.1021/acsami.8b08125 ↗
39. Theranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells10.1038/s41419-019-2182-0 ↗
40. Lipidic cubic-phase nanoparticles (cubosomes) loaded with doxorubicin and labeled with 177Lu as a potential tool for combined chemo and internal radiotherapy for cancers10.3390/nano10112272 ↗
41. In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting10.1016/j.apsb.2014.12.001 ↗
42. The inhibitory function of icariin in cell model of benign prostatic hyperplasia by upregulation of miR-7
43. Optimized icariin cubosomes exhibit augmented cytotoxicity against SKOV-3 ovarian cancer cells10.3390/pharmaceutics13010020 ↗
44. Preparation and characterization of SN-38-encapsulated phytantriol cubosomes containing α-monoglyceride additives10.1248/cpb.c15-00984 ↗
45. Curcumin loaded nano cubosomal hydrogel: preparation, in vitro characterization and antibacterial activity
46. Preparation, characterisation and evaluation of curcumin with piperine-loaded cubosome nanoparticles10.3109/02652048.2014.885607 ↗
47. Comparison of cubosomes and liposomes for the encapsulation and delivery of curcumin10.1039/D0SM01655A ↗
48. T101-Loaded cubosomes as an alternative for improved glioblastoma therapy10.2147/IJN.S265061 ↗
49. Folic acid-targeted etoposide cubosomes for theranostic application of cancer cell imaging and therapy10.12659/MSM.904683 ↗
50. A reflection on the mechanism of the role of nanoparticles in increasing the efficacy of anti-tumour properties of docetaxel10.1007/s40139-021-00223-3 ↗
51. Nanostructured cubosomes in a thermoresponsive depot system: an alternative approach for the controlled delivery of docetaxel10.1208/s12249-015-0369-y ↗
52. Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies10.1016/S0168-3659(02)00175-X ↗
53. Thermodynamic studies on the gel-sol transition of some pluronic polyols10.1016/0378-5173(84)90022-X ↗
54. Development of methotrexate-loaded cubosomes with improved skin permeation for the topical treatment of rheumatoid arthritis10.1007/s13204-019-00976-9 ↗
55. Role of autophagy and apoptosis in non-small-cell lung cancer10.3390/ijms18020367 ↗
56. Overcoming cancer therapeutic bottleneck by drug repurposing
57. Repurposing bedaquiline for effective non-small cell lung cancer (NSCLC) therapy as inhalable cyclodextrin-based molecular inclusion complexes10.3390/ijms22094783 ↗
58. Inhalable bedaquiline-loaded cubosomes for the treatment of non-small cell lung cancer (NSCLC)10.1016/j.ijpharm.2021.121046 ↗
59. Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies
60. Construction and evaluation of folic acid-modified 3-bromopyruvate cubosomes10.12659/MSM.924620 ↗
61. Development of nanostructured liquid crystalline formulation of anti-cancer drug as a new drug delivery system10.1007/s12247-019-09371-x ↗
62. Local chemotherapy of F98 rat glioblastoma with paclitaxel and carboplatin embedded in liquid crystalline cubic phases10.1007/s11060-004-3010-6 ↗
63. Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes10.1186/s12885-018-4727-5 ↗
64. Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity
65. pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment10.1039/C4CC10274F ↗
66. Design and assembly of pH-sensitive lipidic cubic phase matrices for drug release10.1021/la403694e ↗
67. Monoolein cubic phase gels and cubosomes doped with magnetic nanoparticles–hybrid materials for controlled drug release10.1021/acsami.6b12889 ↗
68. pH responsiveness of hexosomes and cubosomes for combined delivery of Brucea javanica oil and doxorubicin10.1021/acs.langmuir.9b02257 ↗
69. Cubosome nanoparticles for enhanced delivery of mitochondria anticancer drug elesclomol and therapeutic monitoring via sub-cellular NAD(P)H multi-photon fluorescence lifetime imaging10.1007/s12274-018-2231-5 ↗
70. A novel glyceryl monoolein-bearing cubosomes for gambogenic acid: preparation, cytotoxicity and intracellular uptake10.1016/j.ijpharm.2015.07.036 ↗
71. Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells10.1016/j.jcis.2018.03.063 ↗
72. Pluronic based cubosomes enhance metformin cytotoxicity in colon cancer cell lines10.1016/j.clinthera.2017.05.082 ↗
73. In vitro and in vivo toxicity and biodistribution of paclitaxel-loaded cubosomes as a drug delivery nanocarrier: a case study using an A431 skin cancer xenograft model10.1021/acsabm.0c00269 ↗
74. Liquid crystalline assembly for potential combinatorial chemo–herbal drug delivery to lung cancer cells10.2147/IJN.S188335 ↗
75. Endocytic pathways of optimized resveratrol cubosomes capturing into human hepatoma cells10.1016/j.biopha.2017.06.093 ↗
76. Anticancer activity of thymoquinone cubic phase nanoparticles against human breast cancer: formulation, cytotoxicity and subcellular localization10.2147/IJN.S263797 ↗
77. Cancer theranostics10.1016/B978-0-12-407722-5.00001-3 ↗
78. Theranostic hexosomes for cancer treatments: an in vitro study10.1039/C6NJ03232J ↗
79. Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics10.1016/j.drudis.2018.02.001 ↗
80. Enhancing cubosome functionality by coating with a single layer of poly-ε-lysine10.1021/am5047872 ↗
81. Cubosomes from hierarchical self-assembly of poly(ionic liquid) block copolymers10.1038/ncomms14057 ↗
82. A review on cubosome: the novel drug delivery system10.30574/gscbps.2018.5.1.0089 ↗