Thymol-Loaded Polymeric Nanocapsules’ Repellent Activity on Nymphs of Rhipicephalus sanguineus Sensu Lato
Source abstract
Abstract
Thymol-loaded polymeric nanocapsules were developed in this study to control volatilization and drug release for repellent application on Rhipicephalus sanguineus nymphs. Policaprolactone-loaded nanocapsules were prepared and characterized by diameter, PdI, zeta potential, pH, entrapment efficiency, and thymol content. Moreover, drug release, skin permeation profile, and repellent activity were evaluated. Nanocapsules showed a mean diameter of 195.7 ± 0.5 nm, a PdI of 0.20 ± 0.01, a zeta potential of −20.6 ± 0.3 mV, a pH of 4.7 ± 0.1, and an entrapment efficiency and a thymol content of 80.1 ± 0.1% and 97.9 ± 0.2%, respectively. The nanosystem progressively released 68.6 ± 2.3% of the thymol over 24 h, demonstrating that it can control drug release. Thymol-loaded nanocapsules showed less epidermis penetration upon skin application than pure thymol (control). Moreover, nanocapsules showed 60–70% repellency for 2 h against Rhipicephalus sanguineus nymphs. Thus, the nanocapsules proved to be a promising alternative for use as an arthropod repellent.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Insect Pest Control Strategies · Insect and Pesticide Research · Toxin Mechanisms and Immunotoxins
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratory of Food, Drugs, and Cosmetics (LTMAC), University of Brasilia, Brasilia 70910-900, DF, Brazil
Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), Faculdade de Farmácia, Universidade Federal de Goiás (UFG), Rua 240, Setor Leste Universitário, Goiânia 74605-170, GO, Brazil
Laboratório de Biologia, Ecologia e Controle de Carrapatos (LaBEC), Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás (UFG), Rua 235, Setor Universitário, Goiânia 74605-050, GO, Brazil
Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico · Fundação de Apoio à Pesquisa do Distrito Federal Induzida · Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
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