PLLA/Graphene Nanocomposites Membranes with Improved Biocompatibility and Mechanical Properties
Source abstract
Abstract
In this work, nanocomposite membranes based on graphene and polylactide were evaluated for mechanical properties and biocompatibility. Single-layer graphene (SLG), graphene nanosheets (GNS), and poly L-lactic acid (PLLA) were prepared through layer-by-layer deposition and homogeneous mixing. The results revealed that PLLA/SLG nanocomposites and PLLA/GNS nanocomposites could show enhanced mechanical properties and biocompatibility. The addition of a tiny amount of SLG significantly improved Young’s modulus and tensile strength of the PLLA matrix by 15.9% and 32.8% respectively, while the addition of the same mass ratio of GNS boosted the elongation at break of the PLLA matrix by 79.7%. These results were ascribed to the crystallinity and interfacial interaction differences resulting from graphene incorporation. Also, improved biocompatibility was observed with graphene incorporation. Such nanocomposites membranes showed a lot of potential as environment-friendly and biomedical materials.
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Research context
OpenAlex topics: Graphene and Nanomaterials Applications · biodegradable polymer synthesis and properties · Graphene research and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science and Engineering, State Key Laboratory of Silicon Materials, Center of Rehabilitation Biomedical Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, China
The Affiliated Sir Run Run Shaw Hospital of Medical College, Zhejiang University, Hangzhou 310016, China
Funding
Natural Science Foundation of Zhejiang Province of China
References (50)
Show source-provided references
1. An overview of the recent developments in polylactide (PLLA) research10.1016/j.biortech.2010.05.092 ↗
2. Poly(lactic acid) crystallization10.1016/j.progpolymsci.2012.07.005 ↗
3. Influence of different sterilization processes on the properties of commercial poly(lactic acid)10.1016/j.msec.2016.07.031 ↗
4. Fabrication of nanostructured porous PLLA scaffold intended for nerve tissue engineering10.1016/j.biomaterials.2003.08.062 ↗
5. Solid-state fermentation for L-lactic acid production from agro wastes using Lactobacillus delbrueckii10.1016/j.procbio.2005.09.013 ↗
6. Polylactic acid: Synthesis and biomedical applications10.1111/jam.14290 ↗
7. Guerra, A.J., Cano, P., Rabionet, M., Puig, T., and Ciurana, J. (2018). 3D-Printed PCL/PLLA Composite Stents: Towards a New Solution to Cardiovascular Problems. Materials, 11.10.3390/ma11091679 ↗
8. 3D printed bone tissue regenerative PLLA/HA scaffolds with comprehensive performance optimizations10.1016/j.matdes.2021.109490 ↗
9. Liu, S.Q., Yu, J.J., Li, H.M., Wang, K.W., Wu, G.H., Wang, B.W., Liu, M.F., Zhang, Y., Wang, P., and Zhang, J. (2020). Controllable Drug Release Behavior of Polylactic Acid (PLLA) Surgical Suture Coating with Ciprofloxacin (CPFX)-Polycaprolactone (PCL)/Polyglycolide (PGA). Polymers, 12.10.3390/polym12020288 ↗
10. Poly(lactic acid) modifications10.1016/j.progpolymsci.2009.12.003 ↗
11. Processing technologies for poly(lactic acid)10.1016/j.progpolymsci.2008.05.004 ↗
12. Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration10.1016/j.msec.2020.110698 ↗
13. Interfacial interactions, crystallization and molecular mobility in nanocomposites of Poly(lactic acid) filled with new hybrid inclusions based on graphene oxide and silica nanoparticles10.1016/j.polymer.2019.01.041 ↗
14. Surface-modification of cellulose nanowhiskers and their use as nanoreinforcers into polylactide: A sustainably-integrated approach10.1016/j.compscitech.2011.11.017 ↗
15. Li, Y.C., Liao, C.Z., and Tjong, S.C. (2019). Synthetic Biodegradable Aliphatic Polyester Nanocomposites Reinforced with Nanohydroxyapatite and/or Graphene Oxide for Bone Tissue Engineering Applications. Nanomaterials, 9.10.3390/nano9040590 ↗
16. Biodegradable poly(lactic acid) nanocomposites reinforced and toughened by carbon nanotubes/clay hybrids10.1016/j.ijbiomac.2020.02.209 ↗
17. Role of poly(ethylene glycol) grafted silica nanoparticle shape in toughened PLLA-matrix nanocomposites10.1016/j.compositesb.2019.03.050 ↗
18. Mayekar, P.C., Castro-Aguirre, E., Auras, R., Selke, S., and Narayan, R. (2020). Effect of Nano-Clay and Surfactant on the Biodegradation of Poly(Lactic Acid) Films. Polymers, 12.10.3390/polym12020311 ↗
19. A biodegradable multifunctional nanofibrous membrane for periodontal tissue regeneration10.1016/j.actbio.2020.03.044 ↗
20. Electrospun thymosin Beta 4 loaded PLGA/PLLA nanofiber/microfiber hybrid yarns for tendon tissue engineering application10.1016/j.msec.2019.110268 ↗
21. Effect of phase morphology and distribution of multi-walled carbon nanotubes on microwave shielding of poly(L-lactide)/poly(epsilon-caprolactone) composites10.1016/j.compositesa.2020.106008 ↗
22. Molecularly Engineered Lignin-Derived Additives Enable Fire-Retardant, UV-Shielding, and Mechanically Strong Polylactide Biocomposites10.1021/acs.biomac.0c01656 ↗
23. Electric field effect in atomically thin carbon films10.1126/science.1102896 ↗
24. Graphene and graphene oxide based aerogels: Synthesis, characteristics and supercapacitor applications10.1016/j.est.2019.101038 ↗
25. Highly Conductive, Scalable, and Machine Washable Graphene-Based E-Textiles for Multifunctional Wearable Electronic Applications10.1002/adfm.202000293 ↗
26. Elastic straining of free-standing monolayer graphene10.1038/s41467-019-14130-0 ↗
27. Design, Fabrication, and Mechanism of Nitrogen-Doped Graphene-Based Photocatalyst10.1002/adma.202003521 ↗
28. Multiscale Structural Modulation of Anisotropic Graphene Framework for Polymer Composites Achieving Highly Efficient Thermal Energy Management10.1002/advs.202003734 ↗
29. Graphene oxide and reduced graphene oxide-based scaffolds in regenerative medicine10.1016/j.ijpharm.2020.119226 ↗
30. Molecular level dispersion of graphene into poly(vinyl alcohol) and effective reinforcement of their nanocomposites10.1002/adfm.200801776 ↗
31. Poly(vinyl alcohol) nanocomposites filled with poly(vinyl alcohol)-grafted graphene oxide10.1021/am300550n ↗
32. Comparative Study of Single-Layer Graphene and Single-Walled Carbon Nanotube-Filled Epoxy Nanocomposites Based on Mechanical and Thermal Properties10.1002/pc.25173 ↗
33. Caminero, M.A., Chacon, J.M., Garcia-PLLAza, E., Nunez, P.J., Reverte, J.M., and Becar, J.P. (2019). Additive Manufacturing of PLLA-Based Composites Using Fused Filament Fabrication: Effect of Graphene NanoPLLAtelet Reinforcement on Mechanical Properties, Dimensional Accuracy and Texture. Polymers, 11.10.3390/polym11050799 ↗
34. Poly(lactic acid)/p-phenylenediamine functionalized graphene oxidized nanocomposites: Preparation, rheological behavior and biodegradability10.1016/j.eurpolymj.2019.109341 ↗
35. Polyethylene glycol functionalized graphene oxide and its influences on properties of Poly(lactic acid) biohybrid materials10.1016/j.compositesb.2018.12.152 ↗
36. Single-Layer Graphene Enhances the Osteogenic Differentiation of Human Mesenchymal Stem Cells In Vitro and In Vivo10.1166/jbn.2016.2254 ↗
37. Graphene/Si-Promoted Osteogenic Differentiation of BMSCs through Light Illumination10.1021/acsami.9b14679 ↗
38. Crystal structure, conformation and morphology of solution spun poly(L-lactide) fibers10.1021/ma00204a041 ↗
39. New insights on the strain-induced mesophase of poly(D, L-lactide):in situ WAXS and DSC study of the thermos-mechanical stability10.1021/ma101430c ↗
40. Preparation of graphene by pressurized oxidation and multiplex reduction and its polymer nanocomposites by masterbatch-based melt blending10.1039/c2jm16203b ↗
41. Improving mechanical performance of injection molded PLLA by controlling crystallinity10.1002/app.27261 ↗
42. Enhancing thermomechanical properties and heat distortion resistance of poly(l-lactide) with high crystallinity under high cooling rate10.1021/sc500783s ↗
43. General crystallization behavior of poly(L-lactic acid)10.1016/0032-3861(80)90315-8 ↗
44. Influence of graphene nanoscrolls on the crystallization behavior and nano-mechanical properties of polylactic acid10.1002/pat.4615 ↗
45. A facile method to produce graphene oxide-g-poly(L-lactic acid) as a promising reinforcement for PLLA nanocomposites10.1016/j.cej.2013.10.034 ↗
46. Physical properties, crystallization, and thermal/hydrolytic degradation of poly(L-lactide)/nano/micro-diamond composites10.1002/mame.201200397 ↗
47. Polylactide/exfoliated graphite nanocomposites with enhanced thermal stability, mechanical modulus, and electrical conductivity10.1002/polb.21956 ↗
48. Polylactide/graphite nanosheets/MWCNTs nanocomposites with enhanced mechanical, thermal and electrical properties10.1007/s13726-011-0008-8 ↗
49. Preparation and thermal characterization of poly(lactic acid) nanocomposites prepared from organoclays based on an amphoteric surfactant10.1016/j.polymdegradstab.2009.01.012 ↗
50. Functionalized graphene sheets for polymer nanocomposites10.1038/nnano.2008.96 ↗