Intermittent Cobalt (II, III) Oxide Exposure Exacerbates Inflammatory Injury through Tumor Necrosis Factor-Alpha-Dependent Bone Marrow-Mediated Trained Immunity
Source abstract
Abstract
-induced, TNF-α-dependent trained immunity exacerbates inflammatory injury in distant organs, including the heart and brain. Our work establishes intermittent exposure as a critical yet overlooked risk paradigm, reveals trained immunity as a mechanistic link between nanoparticles and inflammatory disorders, and positions TNF-α as a potential therapeutic target to mitigate pollution-related risks.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neutrophil, Myeloperoxidase and Oxidative Mechanisms · Arsenic contamination and mitigation · Heavy Metal Exposure and Toxicity
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Occupational and Environmental Health, School of Public Health
Qingdao University
ZaoZhuang Center for Disease Control and Prevention
School of Public Health and Key Laboratory of Public Health Safety
MOE, Fudan University
Funding
Natural Science Foundation of Qingdao Municipality · National Natural Science Foundation of China · Joint Research Center for Occupational Medicine and Health of IHM, Anhui University of Science and Technology
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