Double Linear Gradient Biointerfaces for Determining Two‐Parameter Dependent Stem Cell Behavior
Source abstract
Abstract
Abstract Two‐parameter contributions of stiffness and wettability display altered behavior of hBM‐MSCs as compared to solely investigating the wettability of the biointerface with a homogenous stiffness. The importance of double parameter influence is identified by using newly developed double linear wettability–stiffness gradients. The interfaces show that substrate stiffness can influence cell adhesion and spreading both positively and negatively in combination with wettability. This effect is validated by decoupling the stiffness gradient using a wettability gradient composed of a monolayer on glass ensuring a homogenous stiffness.
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Research context
OpenAlex topics: Cellular Mechanics and Interactions · Surface Modification and Superhydrophobicity · Adhesion, Friction, and Surface Interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
University of Groningen University Medical Center Groningen Department of Biomedical Engineering-FB40 A. Deusinglaan 1 9713 AV Groningen The Netherlands
University of Groningen University Medical Center Groningen W.J. Kolff Institute for Biomedical Engineering and Materials Science-FB41 A. Deusinglaan 1 9713 AV Groningen The Netherlands
University of Groningen Zernike Institute for Advanced Materials Nijenborgh 4 9747 AG Groningen The Netherlands
Funding
University Medical Center Groningen · China Scholarship Council
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