DNA‐Mediated Assembly of Gold Nanoparticles and Applications in Bioanalysis
Source abstract
Abstract
Abstract DNA‐mediated gold nanoparticles (AuNPs) assembly has drawn great attention due to the controllable parameters and properties. In general, DNA sequences working as linkers or templates precisely control the assembly of AuNPs through the Watson–Crick base pairing. Diverse assembly structures show great potential in bioanalysis due to the unique optical characteristics, which can be tuned by the shape, size, composition, particles interactive status and the dielectric constant of the surrounding medium of AuNPs. They exhibit excellent performances for the detection of nucleic acids, proteins, small molecules and other biomarkers. In this review, we present a general overview of the construction of DNA‐mediated AuNP assemblies and the recent advances of these assemblies as high‐performance biosensors. Future directions and major challenges in bioanalysis are also discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Biomedical Information Engineering of Education Ministry School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 People's Republic of China
State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and Engineering Xi'an Jiaotong University Xi'an Shaanxi 710049 People's Republic of China
Funding
National Natural Science Foundation of China
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