Virus‐Based Nanomotors for Cargo Delivery
Source abstract
Abstract
Abstract Self‐propelled nanomotors based on virus structure were designed, fabricated and characterized. Capsids from plant virus were covered on one hemisphere with platinum layer to promote motion in the presence of hydrogen peroxide. The Janus viral nanomotors (JVNs) with 25–30 nm diameter from brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) showed motion speeds of up to 9 μm/sec, depending of the peroxide fuel concentration in the medium. The JVNs can carry and deliver the chemo‐therapeutic drug Tamoxifen, and they are able to internalize into breast tumor cells without any functionalization. The therapeutic payload is released by a pH‐driven delivery action of the nanomotor. Here, the first proof of concept of a self‐propelled virus‐like nanoparticle is demonstrated. The attractive capabilities of nanomotors based on virus‐like nanoparticles (VLPs) pave the way to diverse biomedical applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Micro and Nano Robotics · Molecular Communication and Nanonetworks · Bacteriophages and microbial interactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de México Km. 107, Carretera Tijuana-Ensenada CP 22800 Ensenada, Baja California México
Department of Nanoengineering University of California at San Diego La Jolla California 92093 United States
Funding
National Council of Science and Technology
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