Multi-Ion Channel Nanomedicines Targeting Zinc Transporter 1/ATPase Copper Transporters Disrupt Copper/Iron Homeostasis to Enhance Tumor Immunotherapy
Source abstract
Abstract
-mediated disruption of cysteine (Cys) metabolism, compromises antioxidant defenses and triggers ferroptosis. This ionic dysregulation induces tumor cell death and promotes release of damage-associated molecular patterns (DAMPs) and mitochondrial DNA (mtDNA), activating immunogenic cell death (ICD) and the cGAS-STING pathway. Resultant dendritic cell (DC) maturation and T-cell activation link ion metabolic interference to systemic immune responses. This study establishes a multi-ion metabolic intervention strategy, advancing tumor immunotherapy paradigms.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Ferroptosis and cancer prognosis · Trace Elements in Health · Immune cells in cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oncology
Xuzhou Central Hospital
Key Laboratory of New Drug Research and Clinical Pharmacy of Jiangsu Province
Xuzhou Medical University
Department of Clinical Laboratory, Huai’an Second People’s Hospital
The Affiliated Huai’an Hospital of Xuzhou Medical University
The Affiliated Pizhou Hospital of Xuzhou Medical University
Department of Orthopaedic Surgery
Lishui Central Hospital and Fifth Afffliated Hospital of Wenzhou Medical University
Department of Thyroid and Breast Surgery
The Affiliated Hospital of Xuzhou Medical University
Funding
Xuzhou Pengcheng Talent Program · Natural Science Foundation of Jiangsu Province · Jiangsu Province High level Hospital Construction Project
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