DataVXACS NanoPaper
journal article·2026-01-13

Leveraging Cisplatin-Derived Prodrugs as Helper Lipids in LNPs to Boost the Efficacy of Cancer Chemoimmunotherapy

Xuanbo Zhang, Shipeng Ning, Feng Fang, Cao Zhou, Zifan Yang, Liping Cao, Kaiyuan Wang, Zunyong Feng, Bingyu Li, Dixian Luo, Xiao Xu, Zhigang Liu, Xiaoyuan Chen, Zhiqiang Yu

ACS Nano· Volume 20· Issue 1
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Source abstract

Abstract

Cisplatin's clinical utility is limited by its toxicity, drug resistance, and promotion of immune suppression due to phosphatidylserine (PS) exposure during tumor cell apoptosis. This study introduces a novel approach that integrates cisplatin-derived lipid prodrugs into lipid nanoparticles (PtLNPs) to overcome these challenges. By converting cisplatin to lipid derivatives, we facilitate its incorporation into LNPs, enhancing both the delivery and protection of functional siRNA/mRNA molecules. The synthesized lipid-Pt prodrugs significantly improved the in vitro delivery efficiency and stability of these nucleic acids. Additionally, a codelivery system combining Xkr8 siRNA and annexin A5 (ANX5) mRNA within PtLNPs effectively mitigated cisplatin-induced PS exposure by inhibiting Xkr8 upregulation and promoting ANX5 expression to bind PS. In vivo studies demonstrated that the PtLNP system substantially enhanced the efficacy of combined chemotherapy and immunotherapy, offering a promising strategy to refine cisplatin-based cancer therapy by integrating nucleic acid delivery technologies.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · S100 Proteins and Annexins · Cell death mechanisms and regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital)

School of Pharmacy

Hainan Medical University

Department of Breast Surgery

The Second Affiliated Hospital of Guangxi Medical University

Department of Diagnostic Radiology, Yong Loo Lin School of Medicine

National University of Singapore

Medical Laboratory of the Third Affiliated Hospital of Shenzhen University

Cancer Center, Dongguan Institute of Clinical Cancer Research

Department of Chemical and Biomolecular Engineering, College of Design and Engineering

Department of Biomedical Engineering, College of Design and Engineering

Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science

Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine

Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors

The Tenth Affiliated Hospital of Southern Medical University (Dongguan People’s Hospital)

Funding

National Medical Research Council · Ministry of Education - Singapore · China Postdoctoral Science Foundation · National Research Foundation Singapore · National University of Singapore · National Natural Science Foundation of China · Shenzhen University

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