DataVXACS NanoPaper
journal article·2025-11-25

Efferocytosis-Mimicking Nanovesicle-Cross-Linked Hydrogel for Dual Immunomodulation and Angiogenesis to Prolong Allogeneic Skin Graft Survival

Shanshan Yuan, Yingqian Chai, Zheng Li, Lihua Jiang, Zheyu Li, Yuting Zhu, Weisong Dong, Jilong Wang, Xiaoyun Pan, Yan Zhang, Songxue Guo, Junjie Deng

ACS Nano· Volume 19· Issue 46
Publisher page
Source abstract

Abstract

Sustained local immunosuppression and angiogenesis to prolong graft survival remain elusive goals in allogeneic transplantation. Biomimcking natural efferocytosis to synchronously recruit and regulate endogenous regulatory T cells (Tregs), anti-inflammatory M2 macrophages, and vascular endothelial cells at the transplantation site provides a strategy to address these challenges. While macrophages and endothelial cells, as phagocytes, can be modulated through efferocytosis; T cells, being nonphagocytes, lack this capability. Herein, we developed an efferocytosis-mimicking nanovesicle-cross-linked hydrogel (EMV-Gel) that functions as a sustainably localized "efferocytosis reservoir" at the transplantation site. This gel releases high intensity of key efferocytosis signals, including "find-me", "eat-me", and apoptotic metabolite signals, thereby facilitating the recruitment and engulfment of T cells, macrophages, and endothelial cells, achieving sustained and simultaneous vascular regeneration alongside the induction of Tregs and M2 macrophages. This work establishes a pro-regenerative niche that orchestrates both vascular remodeling and sustained immunosuppression, prolonging allogeneic skin graft survival.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Phagocytosis and Immune Regulation · Wound Healing and Treatments · Immune cells in cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Joint Centre of Translational Medicine

The First Affiliated Hospital of Wenzhou Medical University

Joint Centre of Translational Medicine, Wenzhou Institute

University of Chinese Academy of Sciences

Zhejiang Engineering Research Center for Tissue Repair Materials

Wenzhou Institute, University of Chinese Academy of Sciences

Eye Institute and Department of Ophthalmology Eye & ENT Hospital, NHC Key laboratory of Myopia and Related Eye Diseases; Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences

Fudan University,

National Clinical Research Center for Ocular Diseases, Eye Hospital

Wenzhou Medical University

Department of Orthopaedics

The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University

Department of Plastic Surgery

The Second Affiliated Hospital, Zhejiang University School of Medicine; Zhejiang Key Laboratory of Trauma, Burn and medical rescue; Zhejiang Provincial Clinical Research Center for Emergency and Critical Disease

Funding

National Natural Science Foundation of China · Wenzhou Scientific Research Project

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