journal article·2025-11-25Open access

Precision at Deep Brain: Noninvasive Temporal Interference Stimulation

Shumao Xu, Han Cui, Xiao Xiao, Farid Manshaii, Guosong Hong, Jun Chen

ACS Nano· Volume 19· Issue 46

Abstract

Temporal interference (TI) electrical stimulation is promising for noninvasive neuromodulation with the potential advantages of deep brain targeting. This technique uses high-frequency electric fields applied transcranially, which intersects within the brain to generate a low-frequency modulation field. This intersection enables precise, noninvasive targeting of deep brain regions, addressing a major limitation of typical noninvasive neuromodulation methods, which often yield scattered effects and reduced precision in deep tissue. Recent advances in TI stimulation, supported by computational models and behavioral studies, have demonstrated efficacy in targeting the hippocampus and modulating neuronal activity without notably affecting cortical regions. Its noninvasive nature, coupled with high energy efficiency and precision, positions TI stimulation as a potential tool for activating deep brain regions crucial for behavior and cognition. This review explores the recent developments in TI stimulation, highlighting its mechanisms and pivotal role in precise, noninvasive neuromodulation. The potential of TI stimulation in treating neurological and psychiatric disorders is emphasized, setting the stage for future advances in neurotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Transcranial Magnetic Stimulation Studies · Neuroscience and Neural Engineering · Neurological disorders and treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering

University of California, Los Angeles

Department of Materials Science and Engineering

Stanford University

Wu Tsai Neurosciences Institute

Funding

National Science Foundation Graduate Research Fellowship Program · Stanford Bio-X · Wu Tsai Neurosciences Institute, Stanford University · American Heart Association · Stanford University · Office of Naval Research · Rita Allen Foundation · Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles · Focused Ultrasound Foundation · Spinal Muscular Atrophy Foundation · National Institutes of Health · National Science Foundation · Pinetops Foundation · NIH Stanford Graduate Training Program in Biotechnology

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