Determination of dimethyl fumarate in textiles by solid phase extraction-high-performance liquid chromatography

To establish a method for the determination of dimethyl fumarate in textiles by solid phase extraction-high performance liquid chromatography,samples were ultrasonic extracted,cleaned and enriched by a Sep-PakФ Vac Silica solid-phase extraction( SPE) cartridge,and separated on a Kromasil C18 column( 250 mm × 4. 6 mm i. d., 5 μm) by using the mobile phase consisting of CH3CN + H2O( 55 /45,V / V). Detection was performed at the wavelength 220 nm using extenal standard method. The result of experiment showed that calibration curve of dimethyl fumarate was linear within the range of 0. 05 ~ 50. 0 mg / L,the limit of detection was found to be 0. 02 mg / kg,and the limit of quantification was be found to be 0. 05 mg / kg. The extraction recoveries were at 91. 2%-102. 1%, average recovery was 96. 4% and the RSDs were at 1. 3%-3. 9%. The developed method is quick, simple and little interferential for the determination of dimethyl fumarate residue in textiles.