Preparation of drug-loaded nanofiber membranes in different solution systems

This paper studies the relationship between the morphology of nanofiber membranes and the properties of the solution systems by varying the ratio of acetone and dichloromethane,viscosity-average molecular weight and concentration of PLLA and the drug loading.SEM is used to observe morphology of formed nanofiber membranes.The result shows that there are many beads in the collector because of low viscosity and big surface tension in the solvent of acetone;if the ratio of acetone and dichloromethane is 1∶2,viscosity-average molecular weight and mass fraction of PLLA is 1×10~5 and 10 percent respectively,the morphology of prepared nanofibers are very good and have no beads on surface;if some amount of alky clarithromycin are added,the concentration of PLLA reduces,the conduction of the solution increases,and the nanofibers′ diameters become fine and confusing in distribution.