Preparation and antibacterial activity of TCC/PLA micro-fibers

Poly(lactic acid) micro-fibers which have antibacterial activity were prepared via electro-spinning by adding antibacterial agent triclocarban(TCC).The effects of solvent,and mass concentration of TCC on the structure and morphology of electrospun TCC/PLA micro-fibers were investigated by scanning electron microscopy(SEM),along with the impact of the amount of antibacterial agent(TCC) on the antibacterial property of the fibers.The results revealed that when the solvent ratio was V(CH2Cl2)∶V(PEG 400)=9∶1,dichloromethane/polyethylene glycol 400 is proven to be suitable for TCC/PLA;and the resulting solution can be successfully electrospun into micro-fibers.As the mass concentration of TCC increased from 0.1% to 0.6%,the structure of the fibers mainly remained unchanged,but the diameter of the fibers increased slightly.When the mass concentration of TCC was 0.5%,the inhibiting efficiency of the composite micro-fibers against Staphylococcus aurous and Escherichia coli was 98.6% and 94.2%,respectively.