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journal article·2025-05-06Open access

Chirality Inversion upon Coassembly of Stereoisomeric Short Peptides with Like-Handedness

Yan Wang, Yurong Zhao, Henghao Yu, Kai Qi, Zhenhua Xie, Xinfeng Ju, Muhan Wang, Yuanhao Jiang, Kate Alston, Hua He, Yubin Ke, Jiqian Wang, Kai Tao, Xuzhi Hu, Feng Zhou, Jian Ren Lu, Hai Xu

ACS Nano· Volume 19· Issue 17
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Source abstract

Abstract

Despite numerous reports devoted to chirality inversion during the self-assembly of single chiral components, chirality inversion in the coassembly of two or more chiral components remains largely unexplored. Here we report the supramolecular chirality inversion via the coassembly of the two different stereoisomers of a minimalistic amphiphilic I 3 K sequence with like-handedness in their self-sorting assembly. The coassembled nanofibrils exhibit noticeable helix inversion in a wide range of mixing ratios, compared to individual peptide nanofibrils. Theoretical simulations reveal that to facilitate the interstrand H-bonding between isomeric β-strands within a mixed β-sheet, those with a homochiral backbone will undergo chirality inversion due to their structural flexibility. The inverted strands with two heterogeneous interfaces within the sheet typically display larger twisting degrees and are responsible for inducing helix inversion of the sheet and final β-sheet nanofibrils, and thus, helix inversion of the final nanofibrils can be regulated by tuning the ratio of the two components. This study lays a foundation for manipulating the suprastructure chirality of peptide bionanomaterials through coassembly.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Chemical Synthesis and Analysis · Supramolecular Self-Assembly in Materials · Molecular spectroscopy and chirality

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biological and Energy Chemical Engineering, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China

Spallation Neutron Source Science Center

Institute of High Energy Physics, Chinese Academy of Sciences

Department of Civil Engineering

Qingdao University of Technology

Biological Physics Group, Department of Physics and Astronomy

The University of Manchester

State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang Key Laboratory of Advanced Equipment Manufacturing and Measurement Technology, Zhejiang-Ireland Joint Laboratory of Bio-Organic Dielectrics & Devices, School of Mechanical Engineering

Zhejiang University

Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials

ZJU-Hangzhou Global Scientific and Technological Innovation Centre

State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 18, Tianshui Middle Road, Lanzhou 730000, Gansu, China

Funding

AstraZeneca · Innovate UK · National Natural Science Foundation of China · Biotechnology and Biological Sciences Research Council

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