Preparation and controlled-release evaluation of tannic acid-cellulose acetate composite nanofibers in sandwich structure

For exploring the application of tannic acid-cellulose acetate composite nanofibers in medical auxiliary materials, electrospinning technology was adopted to prepare a sandwich type composite composed of gauge-nanofiber-gauge,in which the mass fraction of cellulose acetate( CA) was 11% and the mass fraction of tannic acid( TA) was 1%,3% and 5% separately. The effects of TA mass fraction, controlled release tempreture,buffer solution condition and sandwich structure on the release performance of TA were investigated as well as the release kinetics of TA. The release rate of TA increases as the TA mass fraction increases; higher tempreture contributes to the release rate of TA; and pH value influnces the TA release performance in such a way that accumulative release amount decreases and release rate drops in the acidic range. Compared with single nanofiber membrane,the sandwich structure materials have better controlled release effect; and the controlled release of TA fits with Ritger-Peppas kinetics model.