DataVXACS NanoPaper
journal article·2024-04-30

Multiwalled Carbon Nanotubes-Reprogrammed Macrophages Facilitate Breast Cancer Metastasis via NBR2/TBX1 Axis

Keshuo Ding, Yaling Zhu, Lang Yan, Linyan Zhu, Tian-Tian Zhang, Rumeng Zhang, Qiushuang Li, Bin Xie, Lin Ding, Limeng Shang, Yi Wang, Panpan Xu, Tao Zhu, Chunying Chen, Yong Zhu

ACS Nano· Volume 18· Issue 17
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Source abstract

Abstract

In recent years, carbon nanotubes have emerged as a widely used nanomaterial, but their human exposure has become a significant concern. In our former study, we reported that pulmonary exposure of multiwalled carbon nanotubes (MWCNTs) promoted tumor metastasis of breast cancer; macrophages were key effectors of MWCNTs and contributed to the metastasis-promoting procedure in breast cancer, but the underlying molecular mechanisms remain to be explored. As a follow-up study, we herein demonstrated that MWCNT exposure in breast cancer cells and macrophage coculture systems promoted metastasis of breast cancer cells both in vitro and in vivo; macrophages were skewed into M2 polarization by MWCNT exposure. LncRNA NBR2 was screened out to be significantly decreased in MWCNTs-stimulated macrophages through RNA-seq; depletion of NBR2 led to the acquisition of M2 phenotypes in macrophages by activating multiple M2-related pathways. Specifically, NBR2 was found to positively regulate the downstream gene TBX1 through H3k27ac activation. TBX1 silence rescued NBR2-induced impairment of M2 polarization in IL-4 & IL-13-stimulated macrophages. Moreover, NBR2 overexpression mitigated the enhancing effects of MWCNT-exposed macrophages on breast cancer metastasis. This study uncovered the molecular mechanisms underlying breast cancer metastasis induced by MWCNT exposure.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Immune cells in cancer · Autophagy in Disease and Therapy · Epigenetics and DNA Methylation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pathology, School of Basic Medicine, Anhui Medical University, Hefei, Anhui 230032, China

Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China

Department of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China

Laboratory Animal Research Center, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China

Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai 200433, China

Department of Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, Anhui China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Chinese Academy of Sciences (CAS), Beijing 100190, China

Funding

National Key Research and Development Program of China · Anhui Medical University · National Natural Science Foundation of China · Basic and Clinical Cooperative Research Promotion Program of Anhui Medical University · Key Program of Natural Scientific Research in Higher Education Institutions of Anhui Province · CSCO Tongshu Cancer Research Program

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