Preparation and sustained-release evaluation of electrospun drug loaded polylactide/silk fibroin nanofibers

Drug loaded composite nanofibers of PLA/SF were prepared via electrospinning the solution made by dissolving aspirin,polylactide(PLA) and silk fibroin(SF) in binary solvent of trifluoroacetic acid and dichloromethane at a volume ratio of 7∶3,and the nanofibers were characterized by morphology and content using scanning electron microscopy(SEM) and infrared spectroscopy(IR).The absorbency of drug released in PBS solution was detected by UV-visible spectroscopy,and then the velocity of drug release was computed.It was found that the average diameter of the blended nanofibers becomes smaller with the increase of the mass fraction of the drug,PLA and SF can be composited very well,releasing rate reaches the maximum when the mass fraction of SF is 3%,and the release of the drug speeds up as the drug concentration increases.