Structure and properties of PLGA/PLA blended nanofibrous membrane

To prepare tissue engineering scaffolds,the PLGA/PLA blended nanofibrous membrane was fabricated via electrospinning with biocompatible PLGA and PLA as raw materials.The morphology,microstructure and mechanical properties of the PLGA/PLA blended nanofibers were characterized by means of SEM,rheometer,TG-DSC and tensile tester.The results show that the PLGA/PLA blended micro-and nanofibers can be prepared successfully by electrospinning.The viscosity of the spinning solution increases with the increase of the blended ratio of PLA,making the diameter of the nanofibers increased,distribution more uniform,pore size bigger and porosity decreased.The thermal analysis indicates that the crystallinity and stability of the scaffolds increase,breaking strength improves and elongation decreases with the increase of the blended ratio of PLA.In order to meet the requirments of different tissue engineering scaffolds,the blended ratio can be adjusted to control the structure and properties of the scaffolds.