Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

Xiaohui Ju; Eliška Javorková; Jan Michalička; Martin Pumera

doi:10.1021/acsnano.4c18874

journal article·2025-05-27Open access

Single-Atom Colloidal Nanorobotics Enhanced Stem Cell Therapy for Corneal Injury Repair

Xiaohui Ju, Eliška Javorková, Jan Michalička, Martin Pumera

ACS Nano· Volume 19· Issue 20

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Source abstract

Abstract

Corneal repair using mesenchymal stem cell therapy faces challenges due to long-term cell survival issues. Here, we design cerium oxide with gold single-atom-based nanorobots (CeSAN-bots) for treating corneal damage in a synergistic combination with stem cells. Powered by glucose, CeSAN-bots exhibit enhanced diffusion and active motion due to the cascade reaction catalyzed by gold and cerium oxide. CeSAN-bots demonstrate a two-fold increase in cellular uptake efficiency into mesenchymal stem cells compared to passive uptake. CeSAN-bots possess intrinsic antioxidant and immunomodulatory properties, promoting corneal regeneration. Validation in a mouse corneal alkali burn model reveals an improvement in corneal clarity restoration when stem cells are incorporated with CeSAN-bots. This work presents a strategy for developing glucose-driven, enzyme-free, single-atom-based ultrasmall nanorobots with promising applications in targeted intracellular delivery in diverse biological environments.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Catalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Corneal Surgery and Treatments · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Future Energy and Innovation Laboratory, Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno 61200, Czech Republic

Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídeňská 1083, Prague 14200, Czech Republic

Department of Cell Biology, Faculty of Science, Charles University, Viničná 7, Prague 12844, Czech Republic

Central European Institute of Technology, Brno University of Technology, Purkyňova 123, Brno 61200, Czech Republic

Advanced Nanorobots & Multiscale Robotics Laboratory, Faculty of Electrical Engineering and Computer Science, VSB-Technical University of Ostrava, 17. listopadu 2172/15, Ostrava 70800, Czech Republic

Department of Medical Research, China Medical University Hospital, China Medical University, No. 91 Hsueh-Shih Road, Taichung 40402, Taiwan

Funding

European Science Foundation · Technology Agency of the Czech Republic · European Commission · European Regional Development Fund · Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy · Grantov? Agentura Cesk? Republiky · NATIONAL CENTRE FOR INDUSTRIAL 3D PRINTING

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