Proliferation inhibition effect of two kinds of betaine amphoteric surfactants on cells

In order to study the relationship between the structure and cytotoxicity of the amphoteric surfactants,the cytotoxicity of betaine amphoteric surfactants,including:four alkyl dimethyl propyl sulphobetaines and three alkyl dimethyl hydroxypropyl sulphobetaines on HeLa cells,Chinese Hamster Ovary(CHO) cells and human skin fibroblast(CCC-ESF-1) cells is assayed by MTT.The results indicated that the cytotoxicity of the chemicals on the cells above gradually becomes larger with their concentration increased.Proliferation inhibition effect of all the compounds increases with the growing in number of carbons.Cytotoxicity of alkyl dimethyl propyl sulphobetaine is lower than that of alkyl dimethyl hydroxypropyl sulphobetaine.