DataVXACS NanoPaper
journal article·2025-03-25

A Bioinspired Defect-Tolerant Hydrogel Medical Patch for Abdominal Wall Defect Repair

Xiang Zhang, Xiaoning Liu, Mohan Wang, Jingjing Zhang, Ke Liu, Ziming Xu, Wanfeng Chen, Jun Hu, Pan Zhang, Yinshun Zhang, Liang Dong, Weiping Xu, Zhao Pan

ACS Nano· Volume 19· Issue 11
Publisher page
Source abstract

Abstract

Point-wise suturing is the standard method for ensuring that patches effectively perform mechanically supportive functions in tissue repair. However, stress concentrations around suture holes can compromise the mechanical stability of patches. In this study, we develop a suturable hydrogel patch with flaw-tolerance capabilities by leveraging multiscale stress deconcentration, inspired by natural silk. This design mitigates stress concentration across two scales through the synergistic integration of nanoscale high-energy crystalline domains and intermolecular interactions. The resulting integral hydrogel patch exhibits superior flaw resistance compared to conventional patches and effectively addresses tissue adhesion issues. To validate the efficacy of the patch, we demonstrate successful in vivo repair of abdominal wall defects in rats, comparing the performance of the proposed patch to commercial mesh patches (Prolene). The integral patch design strategy present here offers a valuable approach for developing patches that can be tailored to meet the mechanical support needs of various tissue repair applications.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Hernia repair and management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine

University of Science and Technology of China

Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences

Zhejiang Cancer Hospital

School of Molecular Medicine, Hangzhou Institute for Advanced Study

University of the Chinese Academy of Sciences

Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, College of Stomatology

Shanghai Jiao Tong University School of Medicine

Department of Orthopedics, Department of Spine Surgery

The First Affiliated Hospital of Anhui Medical University

Department of Ophthalmology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine

College of Materials Science and Engineering

Zhejiang University of Technology

Department of Geriatrics, Gerontology Institute of Anhui Province, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine

Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy

Funding

Anhui Medical University · National Natural Science Foundation of China · Translational Medicine of Anhui Province · Natural Science Foundation of Hangzhou Municipality

References (40)

Show source-provided references
1. 10.1038/s41586-024-07381-510.1038/s41586-024-07381-5 ↗
2. 10.1126/science.abo254210.1126/science.abo2542 ↗
3. 10.1038/s41467-023-42008-910.1038/s41467-023-42008-9 ↗
4. 10.1038/s41551-021-00796-910.1038/s41551-021-00796-9 ↗
5. 10.1038/s41551-022-00905-210.1038/s41551-022-00905-2 ↗
6. 10.1038/s41467-024-46003-610.1038/s41467-024-46003-6 ↗
7. 10.1021/acsnano.0c1072410.1021/acsnano.0c10724 ↗
8. 10.1016/j.joule.2022.06.01310.1016/j.joule.2022.06.013 ↗
9. 10.1109/ACCESS.2020.303771510.1109/ACCESS.2020.3037715 ↗
10. 10.1038/s41467-020-17301-610.1038/s41467-020-17301-6 ↗
11. 10.1038/s41467-020-16040-y10.1038/s41467-020-16040-y ↗
12. 10.1016/j.jvs.2016.07.13110.1016/j.jvs.2016.07.131 ↗
13. 10.1016/j.jmbbm.2017.05.00810.1016/j.jmbbm.2017.05.008 ↗
14. 10.1002/bit.2774310.1002/bit.27743 ↗
15. 10.1016/j.jse.2011.08.04510.1016/j.jse.2011.08.045 ↗
16. 10.1038/s41586-019-1710-510.1038/s41586-019-1710-5 ↗
17. 10.1038/s41467-021-27529-510.1038/s41467-021-27529-5 ↗
18. 10.1038/s41467-023-40753-510.1038/s41467-023-40753-5 ↗
19. 10.1038/s41551-021-00720-110.1038/s41551-021-00720-1 ↗
20. 10.1016/j.mtbio.2023.10069110.1016/j.mtbio.2023.100691 ↗
21. 10.1097/PRS.000000000000758410.1097/PRS.0000000000007584 ↗
22. 10.1016/j.engreg.2020.05.00210.1016/j.engreg.2020.05.002 ↗
23. 10.1002/adma.20241208310.1002/adma.202412083 ↗
24. 10.1038/s41467-024-48468-x10.1038/s41467-024-48468-x ↗
25. 10.1038/nmat270410.1038/nmat2704 ↗
26. 10.1021/nl203108t10.1021/nl203108t ↗
27. 10.1038/natrevmats.2018.810.1038/natrevmats.2018.8 ↗
28. 10.1038/s41467-022-31883-310.1038/s41467-022-31883-3 ↗
29. 10.1038/s41467-025-56340-910.1038/s41467-025-56340-9 ↗
30. 10.1126/science.abg632010.1126/science.abg6320 ↗
31. 10.1016/j.eml.2017.07.00210.1016/j.eml.2017.07.002 ↗
32. 10.1126/sciadv.aau852810.1126/sciadv.aau8528 ↗
33. 10.1021/acsmacrolett.8b0004510.1021/acsmacrolett.8b00045 ↗
34. 10.1016/j.eml.2016.09.01010.1016/j.eml.2016.09.010 ↗
35. 10.1016/j.engfracmech.2017.10.01810.1016/j.engfracmech.2017.10.018 ↗
36. 10.1039/C8SM00460A10.1039/C8SM00460A ↗
37. 10.1073/pnas.190301911610.1073/pnas.1903019116 ↗
38. 10.1016/j.jmbbm.2011.09.01810.1016/j.jmbbm.2011.09.018 ↗
39. 10.1002/adma.20221062410.1002/adma.202210624 ↗
40. 10.1021/acsnano.2c1210410.1021/acsnano.2c12104 ↗