journal article·2024-07-09

Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly

Lingzhi Cao, Xinjian Yang, Yimei Li, Yang Yang, Qiulin Liu, Massimo Bottini, Yi Jin, Bei Wang, Jinchao Zhang, Xing-jie Liang

ACS Nano· Volume 18· Issue 27
Publisher page

Abstract

Tumor metastasis remains a major challenge in cancer management. Among various treatment strategies, immune cell-based cancer therapy holds a great potential for inhibiting metastasis. However, its wide application in cancer therapy is restricted by complex preparations, as well as inadequate homing and controllability. Herein, we present a groundbreaking approach for bioorthogonally manipulating tumor-NK (natural killer) cell assembly to inhibit tumor metastasis. Multiple dibenzocyclootyne (DBCO) groups decorated long single-stranded DNA were tail-modified on core-shell upconversion nanoparticles (CSUCNPs) and condensed by photosensitive chemical linker (PC-Linker) DNA to shield most of the DBCO groups. On the one hand, the light-triggered DNA scaffolds formed a cross-linked network by click chemistry, effectively impeding tumor cell migration. On the other hand, the efficient cellular assembly facilitated the effective communication between tumor cells and NK-92 cells, leading to enhanced immune response against tumors and further suppression of tumor metastasis. These features make our strategy highly applicable to a wide range of metastatic cancers.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry and Materials Science, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, PR China

Department of Experimental Medicine, University of Rome Tor Vergata, Rome 00133, Italy

Sanford Burnham Prebys, La Jolla,California 92037, United States

College of Basic Medical Science, Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-autoimmune Diseases of Hebei Province, Hebei University, Baoding 071002, PR China

Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, PR China

Funding

Natural Science Foundation of Hebei Province · High-end Foreign Experts Recruitment Plan of China · Hebei University · National Natural Science Foundation of China · Hebei Province Innovation Capability Enhancement Plan Project · Government Guided Local Science and Technology Development Fund Projects of Hebei Province · Hebei Province Higher Education Science and Technology Research Project

References (55)

Show source-provided references
1. 10.3322/caac.2182010.3322/caac.21820 ↗
2. 10.1186/s12943-023-01914-810.1186/s12943-023-01914-8 ↗
3. 10.1038/s41467-023-42571-110.1038/s41467-023-42571-1 ↗
4. 10.1038/s41467-023-43803-010.1038/s41467-023-43803-0 ↗
5. 10.1021/jacs.1c0703610.1021/jacs.1c07036 ↗
6. 10.1126/sciadv.ade788010.1126/sciadv.ade7880 ↗
7. 10.1016/j.biomaterials.2020.12005510.1016/j.biomaterials.2020.120055 ↗
8. 10.1038/s41467-020-18794-x10.1038/s41467-020-18794-x ↗
9. 10.1002/smll.20210764010.1002/smll.202107640 ↗
10. 10.1126/sciadv.ade212010.1126/sciadv.ade2120 ↗
11. 10.1021/acs.nanolett.0c0420910.1021/acs.nanolett.0c04209 ↗
12. 10.1016/j.mattod.2022.01.02310.1016/j.mattod.2022.01.023 ↗
13. 10.1002/advs.20230515010.1002/advs.202305150 ↗
14. 10.1016/j.actbio.2022.10.01610.1016/j.actbio.2022.10.016 ↗
15. 10.1186/s12943-023-01748-410.1186/s12943-023-01748-4 ↗
16. 10.1016/j.nantod.2022.10166110.1016/j.nantod.2022.101661 ↗
17. 10.1016/j.apsb.2021.09.02110.1016/j.apsb.2021.09.021 ↗
18. 10.1038/s41467-021-22645-810.1038/s41467-021-22645-8 ↗
19. 10.1126/sciadv.elocation-id10.1126/sciadv.elocation-id ↗
20. 10.1021/jacs.0c1124510.1021/jacs.0c11245 ↗
21. 10.1021/jacs.9b0472510.1021/jacs.9b04725 ↗
22. 10.1002/ange.20201027810.1002/ange.202010278 ↗
23. 10.1002/adma.20220698910.1002/adma.202206989 ↗
24. 10.1002/adma.20200180810.1002/adma.202001808 ↗
25. 10.1002/anie.20211656910.1002/anie.202116569 ↗
26. 10.1002/adma.20130459310.1002/adma.201304593 ↗
27. 10.1039/D1SC01637G10.1039/D1SC01637G ↗
28. 10.1021/jacs.0c1235810.1021/jacs.0c12358 ↗
29. 10.1021/jacs.0c0158010.1021/jacs.0c01580 ↗
30. 10.1021/acs.nanolett.3c0187810.1021/acs.nanolett.3c01878 ↗
31. 10.1002/adma.20230712910.1002/adma.202307129 ↗
32. 10.1002/adfm.20230907010.1002/adfm.202309070 ↗
33. 10.1016/j.nantod.2023.10206110.1016/j.nantod.2023.102061 ↗
34. 10.1002/adma.20221171710.1002/adma.202211717 ↗
35. 10.1039/D3CS00944K10.1039/D3CS00944K ↗
36. 10.1021/jacs.9b1100110.1021/jacs.9b11001 ↗
37. 10.1002/anie.20221533210.1002/anie.202215332 ↗
38. 10.1002/ange.20220380010.1002/ange.202203800 ↗
39. 10.1002/adma.20230953410.1002/adma.202309534 ↗
40. 10.1126/sciadv.aav719910.1126/sciadv.aav7199 ↗
41. 10.1021/jacs.8b0986710.1021/jacs.8b09867 ↗
42. 10.1016/j.cej.2023.14521110.1016/j.cej.2023.145211 ↗
43. 10.1016/j.ccell.2023.01.00110.1016/j.ccell.2023.01.001 ↗
44. 10.1002/anie.20200926310.1002/anie.202009263 ↗
45. 10.1002/adfm.20220260310.1002/adfm.202202603 ↗
46. 10.1136/jitc-2020-00174010.1136/jitc-2020-001740 ↗
47. 10.1186/s12943-023-01893-w10.1186/s12943-023-01893-w ↗
48. 10.1002/anie.20200214510.1002/anie.202002145 ↗
49. 10.1182/blood-2021-15325810.1182/blood-2021-153258 ↗
50. 10.1158/2159-8290.CD-23-029910.1158/2159-8290.CD-23-0299 ↗
51. 10.1021/acsnano.2c0498310.1021/acsnano.2c04983 ↗
52. 10.1021/jacs.3c0204910.1021/jacs.3c02049 ↗
53. 10.1039/D0RA01832E10.1039/D0RA01832E ↗
54. 10.1002/anie.20060297510.1002/anie.200602975 ↗
55. 10.1016/j.jcis.2020.10.01410.1016/j.jcis.2020.10.014 ↗