DataVXACS NanoPaper
journal article·2023-12-26

A Core Structural Protein That Builds the Locust Mandible with a Mechanical Gradient

Huitang Qi, Yi Ding, Yingda Teng, Xiangyu Liang, Lei Chen, Jianli Ma, Qing Yang, Tian Liu

ACS Nano· Volume 17· Issue 24
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Source abstract

Abstract

Natural materials, such as locust mandibles and squid beaks, define significant mechanical gradients that have been attributed to the chemical gradients of their specialized structural proteins (SPs). However, the mechanism by which SPs form chemical gradients in these materials remains unknown. In this study, a highly abundant histidine-rich structural protein ( Lm MHSP) was identified in the mandible of a migratory locust ( Locusta migratoria ). Lm MHSP was proven by both in vivo and in vitro evidence to act as a core building block of the mandible with a variety of synergistic functions including chitin binding, matrix formation via liquid–liquid phase separation, chemical cross-linking, and metal coordination. Furthermore, we found that the SP gradient in the locust mandible stems from the chitin-binding activity of Lm MHSP and different microstructures of chitin scaffolds in different regions. These findings advance our understanding of the formation mechanisms of natural biomaterials and have implications for the fabrication of biomimetic materials.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Silk-based biomaterials and applications · Cellular Mechanics and Interactions · Biochemical and Structural Characterization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China

Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518120, China

Institute of Bast Fiber Crops and Center of Southern Economic Crops, Chinese Academy of Agricultural Sciences, Changsha 410205, China

Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China

Funding

National Key Research and Development Program of China · Science and Technology Foundation of Shenzhen City · National Natural Science Foundation of China

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