journal article·2025-04-08

Nanocomposite Hydrogels and Micro/Nanostructures for Printing Organoids

Daixi Xie, Bingda Chen, Wenqing Wang, Wenjing Guo, Zhiyuan Sun, Long Wang, Bin Shi, Yanlin Song, Meng Su

ACS Nano· Volume 19· Issue 13
Publisher page

Abstract

Organoids are 3D artificial miniature organs composed of a cluster of self-renewing and self-organizing cells in vitro, which mimic the functions of real organs. Nanotechnologies, including the preparation of nanomaterials and the fabrication of micro/nanostructures, have been proven to promote cell proliferation, guide cell differentiation, and regulate cell self-organization, showing great promise in engineering organoids. In this Perspective, different types of nanocomposite hydrogels for organoid culture are summarized, the effects of micro/nanostructures on organoid growth and development are discussed, and 3D bioprinting technologies for constructing organoid models are introduced.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation · Additive Manufacturing and 3D Printing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing Engineering Research Center of Nanomaterials for Green Printing Technology, Beijing National Laboratory for Molecular Sciences (BNLMS), Zhongguancun North First Street 2, 100190 Beijing, P. R. China

University of Chinese Academy of Sciences, Yuquan Road No. 19A, 100049 Beijing, P. R. China

Macao Institute of Materials Science and Engineering, Faculty of Innovation Engineering

Macau University of Science and Technology

Department of Orthopedics

the Fourth Medical Center of Chinese PLA General Hospital

Department of Organ Transplantation

the Third Medical Center of PLA General Hospital

Funding

Beijing National Laboratory for Molecular Sciences · National Key Research and Development Program of China · National Natural Science Foundation of China

References (58)

Show source-provided references
1. 10.1038/s41574-022-00733-z10.1038/s41574-022-00733-z ↗
2. 10.1016/j.fmre.2023.12.01910.1016/j.fmre.2023.12.019 ↗
3. 10.1016/j.devcel.2016.08.01410.1016/j.devcel.2016.08.014 ↗
4. 10.1126/science.aaw756710.1126/science.aaw7567 ↗
5. 10.1038/s41578-021-00279-y10.1038/s41578-021-00279-y ↗
6. 10.1038/ncb331210.1038/ncb3312 ↗
7. 10.1016/j.cell.2023.10.03010.1016/j.cell.2023.10.030 ↗
8. 10.1038/s43018-022-00359-010.1038/s43018-022-00359-0 ↗
9. 10.1038/s41591-020-01145-010.1038/s41591-020-01145-0 ↗
10. 10.1038/s41586-020-2901-910.1038/s41586-020-2901-9 ↗
11. 10.1007/s42242-020-00124-110.1007/s42242-020-00124-1 ↗
12. 10.1021/acsnano.1c0370710.1021/acsnano.1c03707 ↗
13. 10.1021/jacs.3c0221010.1021/jacs.3c02210 ↗
14. 10.1126/science.aaw902110.1126/science.aaw9021 ↗
15. 10.1016/j.actbio.2022.08.01410.1016/j.actbio.2022.08.014 ↗
16. 10.1016/j.cell.2023.12.01210.1016/j.cell.2023.12.012 ↗
17. 10.1038/s41586-023-06991-910.1038/s41586-023-06991-9 ↗
18. 10.1016/j.pmatsci.2023.10121610.1016/j.pmatsci.2023.101216 ↗
19. 10.1038/s41392-021-00544-010.1038/s41392-021-00544-0 ↗
20. 10.1002/advs.20200213510.1002/advs.202002135 ↗
21. 10.1038/nature2016810.1038/nature20168 ↗
22. 10.1002/advs.20220600410.1002/advs.202206004 ↗
23. 10.1016/j.bioactmat.2024.02.01610.1016/j.bioactmat.2024.02.016 ↗
24. 10.1038/s41578-018-0077-910.1038/s41578-018-0077-9 ↗
25. 10.1038/s41467-019-13605-410.1038/s41467-019-13605-4 ↗
26. 10.1007/s12274-022-5115-710.1007/s12274-022-5115-7 ↗
27. 10.1039/D2TC04967H10.1039/D2TC04967H ↗
28. 10.1002/adom.20210183510.1002/adom.202101835 ↗
29. 10.1016/j.bioactmat.2022.09.02510.1016/j.bioactmat.2022.09.025 ↗
30. 10.1021/acsnano.3c0140410.1021/acsnano.3c01404 ↗
31. 10.1038/s41563-023-01611-310.1038/s41563-023-01611-3 ↗
32. 10.1039/D4MH00228H10.1039/D4MH00228H ↗
33. 10.1039/C8TB02419G10.1039/C8TB02419G ↗
34. 10.1002/adma.20210298110.1002/adma.202102981 ↗
35. 10.1016/j.mattod.2018.07.01610.1016/j.mattod.2018.07.016 ↗
36. 10.1016/j.nantod.2022.10158410.1016/j.nantod.2022.101584 ↗
37. 10.1002/adma.20210314810.1002/adma.202103148 ↗
38. 10.1002/advs.20220355710.1002/advs.202203557 ↗
39. 10.1038/s41467-022-28788-610.1038/s41467-022-28788-6 ↗
40. 10.1021/acsnano.7b0344910.1021/acsnano.7b03449 ↗
41. 10.1021/acsnano.4c0784410.1021/acsnano.4c07844 ↗
42. 10.1038/s41592-019-0325-y10.1038/s41592-019-0325-y ↗
43. 10.1038/s41467-023-37953-410.1038/s41467-023-37953-4 ↗
44. 10.1002/smll.20210775710.1002/smll.202107757 ↗
45. 10.1038/s41563-021-01136-710.1038/s41563-021-01136-7 ↗
46. 10.1016/j.biomaterials.2022.12180210.1016/j.biomaterials.2022.121802 ↗
47. 10.1038/s41551-020-0565-210.1038/s41551-020-0565-2 ↗
48. 10.1088/1758-5090/ad963710.1088/1758-5090/ad9637 ↗
49. 10.1002/adma.20221063110.1002/adma.202210631 ↗
50. 10.1038/s41563-020-00803-510.1038/s41563-020-00803-5 ↗
51. 10.1016/j.xcrm.2020.10016110.1016/j.xcrm.2020.100161 ↗
52. 10.1063/1.508720610.1063/1.5087206 ↗
53. 10.1002/smll.20210499610.1002/smll.202104996 ↗
54. 10.1016/j.cej.2024.15655410.1016/j.cej.2024.156554 ↗
55. 10.1007/s40843-024-2933-810.1007/s40843-024-2933-8 ↗
56. 10.1038/s41551-022-00856-810.1038/s41551-022-00856-8 ↗
57. 10.1038/s41565-022-01096-210.1038/s41565-022-01096-2 ↗
58. 10.1002/adma.20240803210.1002/adma.202408032 ↗