DataVXACS NanoPaper
journal article·2024-08-27

Mechanistic Interrogation on Wound Healing and Scar Removing by the Mo4/3B2–x Nanoscaffold Revealed Regulated Amino Acid and Purine Metabolism

Dingkun Zhang, Man Zhu, Pei Xu, Xue Wen, Ge Liang, Wen Zheng, Yu Zeng, Tong Sun, Rong Fan, Yang Lu, Xueqin Tan, Meng Gong, Tingting Wang, Junjie Chen, Junwen Guan

ACS Nano· Volume 18· Issue 34
Publisher page
Source abstract

Abstract

Wound rehabilitation is invariably time-consuming, scar formation further weakens therapeutic efficacy, and detailed mechanisms at the molecular level remain unclear. In this work, a Mo 4/3 B 2– x nanoscaffold was fabricated and utilized for wound healing and scar removing in a mice model, while metabolomics was used to study the metabolic reprogramming of metabolome during therapy at the molecular level. The results showed that transition metal borides, called Mo 4/3 B 2– x nanoscaffolds, could mimic superoxide dismutase and glutathione peroxidase to eliminate excess reactive oxygen species (ROS) in the wound microenvironment. During the therapeutic process, the Mo 4/3 B 2– x nanoscaffold could facilitate the regeneration of wounds and removal of scars by regulating the biosynthesis of collagen, fibers, and blood vessels at the pathological, imaging, and molecular levels. Subsequent metabolomics study revealed that the Mo 4/3 B 2– x nanoscaffold effectively ameliorated metabolic disorders in both wound and scar microenvironments through regulating ROS-related pathways including the amino acid metabolic process (including glycine and serine metabolism and glutamate metabolism) and the purine metabolic process. This study is anticipated to illuminate the potential clinical application of the Mo 4/3 B 2– x nanoscaffold as an effective therapeutic agent in traumatic diseases and provide insights into the development of analytical methodology for interrogating wound healing and scar removal-related metabolic mechanisms.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Wound Healing and Treatments · Graphene and Nanomaterials Applications · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

Laboratory of Aging Research, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610050, P. R. China

Department of Pathology, Deyang People’s Hospital, Deyang 618000, P. R. China

Department of Plastic and Burn Surgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

Metabolomics and Proteomics Technology Platform, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

Department of Mechanical Engineering, City University of Hong Kong, Kowloon 999077, Hong Kong SAR, P. R. China

Chengdu Research Institute, City University of Hong Kong, Chengdu 610200, P. R. China

Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, P. R. China

Funding

West China Hospital, Sichuan University · Science and Technology Department of Sichuan Province · National Natural Science Foundation of China

References (49)

Show source-provided references
1. 10.1111/j.1067-1927.2004.12601.x10.1111/j.1067-1927.2004.12601.x ↗
2. 10.1016/j.biomaterials.2021.12094810.1016/j.biomaterials.2021.120948 ↗
3. 10.1159/00035747710.1159/000357477 ↗
4. 10.1016/j.foodchem.2023.13544410.1016/j.foodchem.2023.135444 ↗
5. 10.3389/fbioe.2016.0008210.3389/fbioe.2016.00082 ↗
6. 10.1016/j.nanoen.2022.10739310.1016/j.nanoen.2022.107393 ↗
7. 10.1016/j.jconrel.2020.09.03910.1016/j.jconrel.2020.09.039 ↗
8. 10.1016/j.mcna.2021.04.00910.1016/j.mcna.2021.04.009 ↗
9. 10.1016/j.biomaterials.2022.12194110.1016/j.biomaterials.2022.121941 ↗
10. 10.1002/adhm.20230077910.1002/adhm.202300779 ↗
11. 10.1039/C8CS00718G10.1039/C8CS00718G ↗
12. 10.1002/adma.20180536810.1002/adma.201805368 ↗
13. 10.1002/adma.20200808910.1002/adma.202008089 ↗
14. 10.1126/science.abf623910.1126/science.abf6239 ↗
15. 10.1039/D0CP06405J10.1039/D0CP06405J ↗
16. 10.3390/metabo1202019410.3390/metabo12020194 ↗
17. 10.1089/wound.2020.121510.1089/wound.2020.1215 ↗
18. 10.1097/SCS.000000000000847010.1097/SCS.0000000000008470 ↗
19. 10.1021/acsnano.1c0420610.1021/acsnano.1c04206 ↗
20. 10.7150/thno.5770110.7150/thno.57701 ↗
21. 10.1080/08977194.2022.207484310.1080/08977194.2022.2074843 ↗
22. 10.1016/j.cytogfr.2022.03.00110.1016/j.cytogfr.2022.03.001 ↗
23. 10.1017/S146239940300581710.1017/S1462399403005817 ↗
24. 10.1002/jcb.3034410.1002/jcb.30344 ↗
25. 10.1177/0271678X23117004110.1177/0271678X231170041 ↗
26. 10.1016/j.stem.2022.01.01210.1016/j.stem.2022.01.012 ↗
27. 10.1089/wound.2021.016110.1089/wound.2021.0161 ↗
28. 10.1016/j.bbrc.2022.04.08510.1016/j.bbrc.2022.04.085 ↗
29. 10.1016/j.biopha.2022.11400410.1016/j.biopha.2022.114004 ↗
30. 10.3389/fimmu.2020.60318710.3389/fimmu.2020.603187 ↗
31. 10.25259/IJDVL_323_202210.25259/IJDVL_323_2022 ↗
32. 10.1007/s00726-013-1486-010.1007/s00726-013-1486-0 ↗
33. 10.1111/iwj.1224610.1111/iwj.12246 ↗
34. 10.1002/path.170078020510.1002/path.1700780205 ↗
35. 10.1080/13880209.2016.118563610.1080/13880209.2016.1185636 ↗
36. 10.1111/j.1524-475x.2008.00435.x10.1111/j.1524-475x.2008.00435.x ↗
37. 10.1016/S0002-9440(10)61151-010.1016/S0002-9440(10)61151-0 ↗
38. 10.1046/j.0022-202x.2001.01697.x10.1046/j.0022-202x.2001.01697.x ↗
39. 10.1097/MNH.000000000000061910.1097/MNH.0000000000000619 ↗
40. Han, C.; Leonardo, T. R.; Romana-Souza, B.; Shi, J.; Altakriti, M.; Ranzer, M. J.; Ferri-Borgogno, S.; Mok, S. C.; Chen, L.; Dipietro, L. A. Microfibril-Associated Protein 5 Regulates Skin Fibroblast Function and Scar Formation; Wound Repair and Regeneration: Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 2022.10.1038/s41598-023-35558-x ↗
41. 10.1016/0022-4804(72)90056-x10.1016/0022-4804(72)90056-x ↗
42. 10.26402/jpp.2019.2.0710.26402/jpp.2019.2.07 ↗
43. 10.1096/fj.12-20962710.1096/fj.12-209627 ↗
44. 10.3390/cells1003065510.3390/cells10030655 ↗
45. 10.1155/2021/885275910.1155/2021/8852759 ↗
46. 10.1371/journal.pone.023037410.1371/journal.pone.0230374 ↗
47. 10.1016/j.trsl.2021.05.00110.1016/j.trsl.2021.05.001 ↗
48. 10.1016/j.cmet.2021.07.01710.1016/j.cmet.2021.07.017 ↗
49. 10.1093/burnst/tkac00710.1093/burnst/tkac007 ↗